Drug × Cancer matrix

Drugs that target a gene either directly (oncogene) or via a synthetic-lethal partner (SLP) of a mutated tumour suppressor (TSG). Cell colour shows the strongest known status of that drug for that cancer subtype: approved clinical trial repositionable (potential reuse, no evidence yet) or blank.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
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Showing 200 of 288 drug-target rows in SSL view, for TSG = DICER1.
Drug TSG SLP (drug target) GBM LUAD SCLC LUSC OAC OSCC PDAC #
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab DICER1 DDR2 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) DICER1 DDR2 4
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib DICER1 SRC 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib DICER1 CSK 3
nivolumab or pembrolizumab (dependent upon approved indication), metformin, rosiglitazone DICER1 PPARD 3
regorafenib DICER1 DDR2 7
bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment DICER1 SRC 2
bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment DICER1 CSK 2
bryostatin 1, paclitaxel DICER1 TNF 2
bryostatin 1, paclitaxel DICER1 PRKCA 2
fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study DICER1 HDAC2 2
motexafin gadolinium, radiation therapy DICER1 RRM2 2
nintedanib DICER1 SRC 2
nintedanib, pembrolizumab DICER1 SRC 2
pembrolizumab, guadecitabine, mocetinostat DICER1 HDAC2 2
pharmacological study, romidepsin DICER1 HDAC2 2
pharmacological study, romidepsin DICER1 HDAC4 2
regorafenib, laboratory biomarker analysis DICER1 DDR2 2
rituximab DICER1 MS4A1 2
vinorelbine, cisplatin, vinorelbine, cisplatin, radiotherapy DICER1 TUBB 2
bethanechol DICER1 CHRM1 7
bosutinib DICER1 SRC 7
carfilzomib DICER1 PSMB8 7
romidepsin DICER1 HDAC2 7
vinorelbine DICER1 TUBB 7
3-dimensional conformal radiation therapy, cognitive assessment, laboratory biomarker analysis, temozolomide, vorinostat DICER1 HDAC2 1
3-dimensional conformal radiation therapy, intensity-modulated radiation therapy (imrt), temozolomide, chloroquine, tumor treating fields therapy (ttf) DICER1 TNF 1
3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, vorinostat DICER1 HDAC2 1
3-dimensional conformal radiation therapy, motexafin gadolinium, temozolomide DICER1 RRM2 1
adjuvant therapy, temozolomide, valproic acid, radiation therapy DICER1 HDAC2 1
adjuvant therapy, temozolomide, valproic acid, radiation therapy DICER1 HDAC9 1
adjuvant therapy, temozolomide, valproic acid, radiation therapy DICER1 PPARD 1
adriamycin, cyclophosphamide, vindesine, valproic acid DICER1 HDAC2 1
adriamycin, cyclophosphamide, vindesine, valproic acid DICER1 HDAC9 1
adriamycin, cyclophosphamide, vindesine, valproic acid DICER1 PPARD 1
afatinib, dasatinib, palbociclib, everolimus, olaparib DICER1 SRC 1
afatinib, dasatinib, palbociclib, everolimus, olaparib DICER1 CSK 1
atorvastatin, temozolomide, radiotherapy DICER1 HDAC2 1
azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab DICER1 HDAC2 1
azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab DICER1 MS4A1 1
bethanechol, gemcitabine, nab-paclitaxel DICER1 CHRM1 1
bevacizumab, dasatinib, placebo DICER1 SRC 1
bevacizumab, dasatinib, placebo DICER1 CSK 1
bevacizumab, temozolomide, vorinostat DICER1 HDAC2 1
byl719, poziotinib, nintedanib, abemaciclib, durvalumab,tremelimumab DICER1 SRC 1
canakinumab, tislelizumab, nab-paclitaxel, gemcitabine DICER1 IL1B 1
capecitabine, vorinostat, radiotherapy, surgery to remove tumor DICER1 HDAC2 1
ce-mark approved laa closure devices, acetylsalicylic acid, clopidogrel, dabigatran, rivaroxaban, apixaban, edoxaban, phenprocoumon, warfarin DICER1 MYC 1
chemotherapy, cladribine, radiation therapy DICER1 RRM2 1
chloroquine DICER1 TNF 1
chloroquine, radiotherapy, temozolomide DICER1 TNF 1
chlorpromazine, temozolomide, radiation therapy DICER1 CHRM1 1
concomitant temozolomide (tmz), radiotherapy, procarbazine, adjuvant temozolomide (tmz), ccnu, vincristine DICER1 TUBB 1
conventional surgery, 3-dimensional conformal radiation therapy, stereotactic radiosurgery, motexafin gadolinium, magnetic resonance imaging, spectroscopy DICER1 RRM2 1
cytoreductive surgery, perifosine, temsirolimus DICER1 PRKCA 1
dabrafenib, trametinib, carboplatin, vincristine DICER1 TUBB 1
dasatinib, erlotinib hydrochloride, gemcitabine hydrochloride DICER1 SRC 1
dasatinib, erlotinib hydrochloride, gemcitabine hydrochloride DICER1 CSK 1
dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis, mutation analysis, nucleic acid sequencing, immunohistochemistry staining method DICER1 SRC 1
dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis, mutation analysis, nucleic acid sequencing, immunohistochemistry staining method DICER1 CSK 1
dasatinib, laboratory biomarker analysis, physiologic testing DICER1 SRC 1
dasatinib, laboratory biomarker analysis, physiologic testing DICER1 CSK 1
dasatinib, mfolfox6 DICER1 SRC 1
dasatinib, mfolfox6 DICER1 CSK 1
dasatinib, pharmacological study DICER1 SRC 1
dasatinib, pharmacological study DICER1 CSK 1
dasatinib, temozolomide, placebo, radiation therapy DICER1 SRC 1
dasatinib, temozolomide, placebo, radiation therapy DICER1 CSK 1
depatuxizumab mafodotin, temozolomide, lomustine DICER1 TUBB 1
dexanabinol DICER1 TNF 1
disulfiram, copper, alkylating agents DICER1 TKT 1
disulfiram, copper, alkylating agents DICER1 TUBB 1
disulfiram, copper, alkylating agents DICER1 P4HB 1
disulfiram, copper, alkylating agents DICER1 HSP90AA1 1
docetaxel, cisplatin, radiation, surgery, vinorelbine, cisplatin DICER1 TUBB 1
etanercept, tocilizumab DICER1 TNF 1
etomidate, midazolam, meperidine DICER1 CHRM1 1
farletuzumab, placebo, carboplatin, paclitaxel, pemetrexed, cisplatin DICER1 FOLR1 1
gemcitabine hydrochloride, tanespimycin DICER1 HSP90AA1 1
gemcitabine, etanercept DICER1 TNF 1
gemcitabine, oxaliplatin, imatinib DICER1 DDR2 1
gemcitabine, sorafenib, vorinostat, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, rosettesep, depfff DICER1 HDAC2 1
gemcitabine, vinorelbine, cisplatin, etoposide, carboplatin DICER1 TUBB 1
imatinib, irinotecan, carboplatin DICER1 DDR2 1
imexon, gemcitabine DICER1 RRM2 1
irinotecan, cisplatin, simvastatin DICER1 HDAC2 1
ketamine, ketamine injectable product, meaning and purpose therapy, placebo, questionnaires DICER1 CHRM1 1
laboratory biomarker analysis, perifosine, temsirolimus, therapeutic conventional surgery DICER1 PRKCA 1
laboratory biomarker analysis, pharmacological study, temozolomide, vorinostat DICER1 HDAC2 1
mebendazole, vincristine, carboplatin, temozolomide, bevacizumab, irinotecan DICER1 TUBB 1
medical cannabis DICER1 IDO1 1
medical cannabis DICER1 NAAA 1
medical cannabis DICER1 SOD1 1
minocycline, placebo, questionnaires DICER1 IL1B 1
motexafin gadolinium DICER1 RRM2 1
motexafin gadolinium, magnetic resonance imaging, surgical procedure DICER1 RRM2 1
nabiximols, temozolomide, nabiximols-matched placebo DICER1 IDO1 1
nabiximols, temozolomide, nabiximols-matched placebo DICER1 NAAA 1
nabiximols, temozolomide, nabiximols-matched placebo DICER1 SOD1 1
paclitaxel, bryostatin 1 DICER1 TNF 1
paclitaxel, bryostatin 1 DICER1 PRKCA 1
patupilone DICER1 TUBB 1
pembrolizumab, vorinostat, temozolomide, radiotherapy DICER1 HDAC2 1
pemetrexed, cetuximab, cisplatin, folic acid, vitamin b12 DICER1 FOLR1 1
perifosine DICER1 PRKCA 1
ponatinib DICER1 SRC 1
recombinant interferon alfa-2b, cisplatin, sodium stibogluconate, dacarbazine, vinblastine DICER1 TUBB 1
regorafenib, lomustine DICER1 DDR2 1
regorafenib, nivolumab, capeox, folfox regimen DICER1 DDR2 1
regorafenib, nivolumab, docetaxel, paclitaxel, irinotecan, trifluridine/tipracil DICER1 DDR2 1
regorafenib, temozolomide DICER1 DDR2 1
romidepsin DICER1 HDAC4 1
romidepsin, azacitidine, nab-paclitaxel, gemcitabine, durvalumab, lenalidomide capsule DICER1 HDAC2 1
romidepsin, azacitidine, nab-paclitaxel, gemcitabine, durvalumab, lenalidomide capsule DICER1 HDAC4 1
romidepsin, laboratory biomarker analysis DICER1 HDAC2 1
romidepsin, laboratory biomarker analysis DICER1 HDAC4 1
selinexor, temozolomide, generic radiation therapy (rt), selective serotonin receptor (5-ht3) antagonists, olanzapine, salt tablets, anti-diarrheal DICER1 CHRM1 1
snx-5422 DICER1 HSP90AA1 1
sorafenib tosylate, valproic acid, sildenafil citrate DICER1 HDAC2 1
sorafenib tosylate, valproic acid, sildenafil citrate DICER1 HDAC9 1
sorafenib tosylate, valproic acid, sildenafil citrate DICER1 PPARD 1
tamoxifen, etoposide DICER1 PRKCA 1
temozolomide, aprepitant, minocycline, disulfiram, celecoxib, sertraline, captopril, itraconazole, ritonavir, auranofin DICER1 IL1B 1
temozolomide, depatuxizumab mafodotin, radiation, placebo for abt-414 DICER1 TUBB 1
temozolomide, lomustine, regorafenib, radiation, paxalisib, val-083, vt1021, troriluzole, adi-peg 20 DICER1 DDR2 1
tinzaparin, tinzaparin DICER1 ITGA4 1
trametinib, vinblastine DICER1 TUBB 1
valproic acid DICER1 HDAC2 1
valproic acid DICER1 HDAC9 1
valproic acid DICER1 PPARD 1
valproic acid, bevacizumab, radiation therapy DICER1 HDAC2 1
valproic acid, bevacizumab, radiation therapy DICER1 HDAC9 1
valproic acid, bevacizumab, radiation therapy DICER1 PPARD 1
valproic acid, simvastatin 20mg, gemcitabine 1000 mg, nab paclitaxel, cisplatin, capecitabine DICER1 HDAC2 1
valproic acid, simvastatin 20mg, gemcitabine 1000 mg, nab paclitaxel, cisplatin, capecitabine DICER1 HDAC9 1
valproic acid, simvastatin 20mg, gemcitabine 1000 mg, nab paclitaxel, cisplatin, capecitabine DICER1 PPARD 1
vinorelbine, xr9576 DICER1 TUBB 1
vorinostat, bevacizumab DICER1 HDAC2 1
vorinostat, bevacizumab, irinotecan DICER1 HDAC2 1
vorinostat, bortezomib, pharmacological study, laboratory biomarker analysis DICER1 HDAC2 1
vorinostat, conventional surgery DICER1 HDAC2 1
vorinostat, temozolomide, diagnostic laboratory biomarker analysis, pharmacological study DICER1 HDAC2 1
vorinostat, temozolomide, magnetic resonance spectroscopic imaging, survey administration DICER1 HDAC2 1
vorinostat, therapeutic conventional surgery, bortezomib DICER1 HDAC2 1
acetylcholine DICER1 CHRM1 7
acetylcholine chloride DICER1 CHRM1 7
acitretin DICER1 RARB 7
adapalene DICER1 RARB 7
alitretinoin DICER1 RARB 7
alpidem DICER1 TSPO 7
anisotropine DICER1 CHRM1 7
anisotropine methylbromide DICER1 CHRM1 7
atropine DICER1 CHRM1 7
atropine sulfate DICER1 CHRM1 7
belantamab mafodotin DICER1 TUBB 7
belinostat DICER1 HDAC2 7
belinostat DICER1 HDAC7 7
belinostat DICER1 HDAC9 7
belinostat DICER1 HDAC4 7
benoxaprofen DICER1 ALOX12 7
benztropine DICER1 CHRM1 7
benztropine mesylate DICER1 CHRM1 7
bethanechol chloride DICER1 CHRM1 7
bexarotene DICER1 RARB 7
bezafibrate DICER1 PPARD 7
biperiden DICER1 CHRM1 7
biperiden hydrochloride DICER1 CHRM1 7
biperiden lactate DICER1 CHRM1 7
cabazitaxel DICER1 TUBB 7
cevimeline DICER1 CHRM1 7
cevimeline hydrochloride DICER1 CHRM1 7
clidinium DICER1 CHRM1 7
clidinium bromide DICER1 CHRM1 7
clofarabine DICER1 RRM2 7
cyclopentolate DICER1 CHRM1 7
cyclopentolate hydrochloride DICER1 CHRM1 7
cycrimine DICER1 CHRM1 7
cycrimine hydrochloride DICER1 CHRM1 7
dasatinib DICER1 SRC 7
dicyclomine DICER1 CHRM1 7
dicyclomine hydrochloride DICER1 CHRM1 7
diphemanil DICER1 CHRM1 7
diphemanil methylsulfate DICER1 CHRM1 7
diphenidol DICER1 CHRM1 7
diphenidol hydrochloride DICER1 CHRM1 7
docetaxel DICER1 TUBB 7
doxapram DICER1 KCNK3 7
doxapram hydrochloride DICER1 KCNK3 7
enasidenib DICER1 IDH2 7
enasidenib mesylate DICER1 IDH2 7
eribulin DICER1 TUBB 7
eribulin mesylate DICER1 TUBB 7
ethopropazine DICER1 CHRM1 7
ethopropazine hydrochloride DICER1 CHRM1 7
etretinate DICER1 RARB 7
fesoterodine DICER1 CHRM1 7
fesoterodine fumarate DICER1 CHRM1 7
flavoxate DICER1 CHRM1 7
flavoxate DICER1 PDE7B 7
flavoxate DICER1 PDE7A 7
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable candidates from cansar.ai — these are potential drug-cancer reuse candidates, not evidence of efficacy.