Drug × Cancer matrix

Drugs that target a gene either directly (oncogene) or via a synthetic-lethal partner (SLP) of a mutated tumour suppressor (TSG). Cell colour shows the strongest known status of that drug for that cancer subtype: approved clinical trial repositionable (potential reuse, no evidence yet) or blank.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
Relationship
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Showing 200 of 49856 drug-target rows in SSL view.
Drug TSG SLP (drug target) GBM LUAD SCLC LUSC OAC OSCC PDAC #
olaparib BRCA1 PARP1 1
olaparib CHEK1 PARP1 1
olaparib BRCA2 PARP2 1
olaparib BRCA2 PARP1 1
olaparib FANCD2 PARP1 1
olaparib FANCD2 PARP2 1
olaparib NF1 PARP1 1
olaparib ATM PARP2 1
olaparib MSH6 PARP1 1
olaparib PARP1 PARP2 1
olaparib CDKN2A PARP1 1
olaparib KMT2D PARP1 1
olaparib BRCA1 PARP2 1
olaparib KDM6A PARP1 1
olaparib RAD21 PARP2 1
olaparib RAD21 PARP1 1
olaparib ERCC3 PARP1 1
olaparib POLD1 PARP2 1
olaparib POLE PARP2 1
olaparib STAG1 PARP2 1
olaparib SMC1A PARP1 1
olaparib POLE PARP1 1
olaparib SMC3 PARP1 1
olaparib STAG1 PARP1 1
olaparib PIK3R1 PARP1 1
olaparib TP53 PARP1 1
olaparib SMC3 PARP2 1
olaparib PMS2 PARP1 1
olaparib SMC1A PARP2 1
sunitinib ATR KIT 7
sunitinib AXIN1 KIT 7
sunitinib BARD1 KIT 7
sunitinib EP300 KIT 7
sunitinib FBXW7 KIT 7
sunitinib SMARCA4 KIT 7
sunitinib BRCA1 PDGFRA 7
sunitinib BRCA1 FLT3 7
sunitinib CUX1 PDGFRB 7
sunitinib APC FLT3 7
sunitinib BRCA2 KIT 7
sunitinib APC PDGFRA 7
sunitinib BRCA2 FLT3 7
sunitinib ATM KDR 7
sunitinib BRCA1 KDR 7
sunitinib TP53 PDGFRA 7
sunitinib APC KIT 7
sunitinib CUX1 KIT 7
sunitinib CUX1 PDGFRA 7
sunitinib TOP1 PDGFRA 7
sunitinib TP53 KDR 7
sunitinib POLD1 KDR 7
sunitinib POLE KDR 7
sunitinib CUX1 CSF1R 7
sunitinib SMAD4 KIT 7
sunitinib PARP1 PDGFRA 6
sunitinib PARP1 KDR 6
sunitinib CHEK1 MET 5
sunitinib KDM6A MET 5
sunitinib CDH1 MET 5
sunitinib CDKN2A MET 5
sunitinib TP53 MET 5
sunitinib ARID2 MET 5
sunitinib VHL PDGFRA 5
sunitinib VHL FLT3 5
sunitinib VHL MET 5
sunitinib SMAD4 MET 5
sunitinib PBRM1 MET 5
sunitinib BAP1 KIT 6
sunitinib SESN2 KDR 6
sunitinib MAP3K1 FLT3 6
sunitinib TSC1 KIT 6
sunitinib TCF3 KIT 5
sunitinib PMS2 KDR 5
docetaxel, thalidomide CREBBP BCL2 4
docetaxel, thalidomide CYLD BCL2 4
docetaxel, thalidomide ERCC5 BCL2 4
docetaxel, thalidomide KEAP1 BCL2 4
docetaxel, thalidomide SMARCB1 BCL2 4
docetaxel, thalidomide PTPRD TUBB1 4
docetaxel, thalidomide CUX1 ORM1 4
docetaxel, thalidomide FH MAP2 4
docetaxel, thalidomide PTPRD MAPT 4
docetaxel, thalidomide PTPRD MAP4 4
docetaxel, thalidomide TP53 MAP4 4
docetaxel, thalidomide PTPRD BCL2 4
docetaxel, thalidomide PTPRD MAP2 4
docetaxel, thalidomide PTPRD NR1I2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab ATR RET 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab ATR KIT 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab AXIN1 KIT 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab AXIN1 RET 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab BAP1 RET 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab BAP1 KIT 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab BARD1 KIT 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab BARD1 RET 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab BRCA2 RET 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab CREBBP ABL1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab EP300 RET 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab EP300 KIT 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab FBXW7 KIT 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab FBXW7 RET 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab FLCN ABL1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab NF2 RET 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab POLD1 RET 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab RECQL4 CTLA4 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab SH2B3 RET 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab SMARCA4 RET 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab SMARCA4 KIT 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab SMARCB1 ABL1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab TBX3 RET 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab TP53 RET 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab BRCA2 CTLA4 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab BRCA2 ABL1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab CREBBP BCL2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab CYLD BCL2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab ERCC5 BCL2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab KEAP1 BCL2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab PIK3R1 ABL1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab PIK3R1 CTLA4 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab SMARCB1 BCL2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab STK11 ABL1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab STK11 CTLA4 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab ARID2 DDR2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab DICER1 DDR2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab BRCA1 PDGFRA 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab BRCA1 VEGFA 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab CDK12 NTRK1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab CUX1 PDGFRB 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab PTPRD TUBB1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab BRCA2 KIT 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab TP53 DDR2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab TP53 RAF1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab APC PDGFRA 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab TP53 NTRK1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab CDKN2A VEGFA 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab ATM KDR 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab SMARCA4 VEGFA 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab BRCA1 KDR 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab CUX1 RET 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab FH MAP2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab TP53 PDGFRA 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab APC VEGFA 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab APC KIT 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab CUX1 KIT 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab CUX1 NTRK1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab TP53 FRK 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab ARID2 FGFR2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab BRCA2 FGFR2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab CUX1 PDGFRA 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab TOP1 PDGFRA 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab MAP3K1 FGFR2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab TP53 KDR 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab POLD1 KDR 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab PTPRD MAPT 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab CUX1 ABL1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab PTPRD MAP4 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab POLE KDR 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab TP53 ABL1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab TP53 MAP4 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab APC ABL1 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab SMAD4 KIT 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab PTPRD BCL2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab PBRM1 FGFR2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab PTPRD MAP2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab PTPRD NR1I2 4
nivolumab, ipilimumab BRCA2 CTLA4 4
nivolumab, ipilimumab PIK3R1 CTLA4 4
nivolumab, ipilimumab STK11 CTLA4 4
paclitaxel + carboplatin, carboplatin + etoposide, gemcitabine + carboplatin, nab-paclitaxel (paclitaxel-albumin) + carboplatin, oxaliplatin + 5-fluorouracil (5fu) + leucovorin (calcium folinate/folinic acid), durvalumab, tremelimumab, nab-paclitaxel (paclitaxel-albumin) + gemcitabine, cisplatin + 5-fluorouracil (5fu) BRCA2 CTLA4 4
paclitaxel + carboplatin, carboplatin + etoposide, gemcitabine + carboplatin, nab-paclitaxel (paclitaxel-albumin) + carboplatin, oxaliplatin + 5-fluorouracil (5fu) + leucovorin (calcium folinate/folinic acid), durvalumab, tremelimumab, nab-paclitaxel (paclitaxel-albumin) + gemcitabine, cisplatin + 5-fluorouracil (5fu) PIK3R1 CTLA4 4
paclitaxel + carboplatin, carboplatin + etoposide, gemcitabine + carboplatin, nab-paclitaxel (paclitaxel-albumin) + carboplatin, oxaliplatin + 5-fluorouracil (5fu) + leucovorin (calcium folinate/folinic acid), durvalumab, tremelimumab, nab-paclitaxel (paclitaxel-albumin) + gemcitabine, cisplatin + 5-fluorouracil (5fu) STK11 CTLA4 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) ATR RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) ATR KIT 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) AXIN1 KIT 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) AXIN1 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) BAP1 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) BAP1 KIT 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) BARD1 KIT 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) BARD1 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) BRCA2 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) CREBBP ABL1 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) EP300 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) EP300 KIT 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) FBXW7 KIT 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) FBXW7 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) FLCN ABL1 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) NF2 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) POLD1 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) SH2B3 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) SMARCA4 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) SMARCA4 KIT 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) SMARCB1 ABL1 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) TBX3 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) TP53 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) BRCA2 ABL1 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) PIK3R1 ABL1 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) STK11 ABL1 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) ARID2 DDR2 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) DICER1 DDR2 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) BRCA1 PDGFRA 4
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable candidates from cansar.ai — these are potential drug-cancer reuse candidates, not evidence of efficacy.