PDE7A

High affinity 3',5'-cyclic-AMP phosphodiesterase 7A UniProt accession Q13946

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:19350606, PubMed:8389765, PubMed:9195912). May have a role in muscle signal transduction (PubMed:9195912)

Source: UniProt

Interacts with CBFA2T3

Source: UniProt
Cytoplasm, cytosol Cytoplasm
Source: UniProt

Found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart (PubMed:9195912). It is expressed as well in two T-cell lines (PubMed:9195912)

Found abundantly in skeletal muscle and at low levels in heart

Source: UniProt

Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain

Source: UniProt

Click a pathway to open the interactive Reactome viewer.

Pathway list and interactive viewer: Reactome

Synthetic Lethal Network

Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to PDE7A, aggregated across our SSL data sources. Click any partner node to view that gene’s page.

Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.

BioGRID SLOrth SynLethDB MexDrugs Multi-source
Sources: BioGRID, SLOrth, SynLethDB, MexDrugs

Clinical Trials

No clinical trials information available.