01
Drug landscape
Approved and repositionable drugs that target the gene directly — or its synthetic-lethal partners when the gene itself is a tumour suppressor.
Synthetic lethal targets, approved drugs, and clinical trials — searchable by gene.
Search any human gene to explore its mutation profile across cancers, the drugs targeting it (directly or via synthetic lethality), and active clinical trials.
Try:
19,844
Genes
7
Cancer subtypes
7,578
Drugs
Live
Clinical trials
02
Clinical trials
Live results from clinicaltrials.gov, filtered to studies that mention the gene as a condition or biomarker.
03
SSL network
A gene’s synthetic-lethal partners aggregated from four databases (BioGRID, SLOrth, SynLethDB, MexDrugs), shown as an interactive graph you can explore and click through.
Data sources
- COSMIC — mutation data
- UniProt — gene function and protein information
- Reactome — biological pathways
- ClinicalTrials.gov — trial registry
- Approved drugs — manually curated from National Cancer Institute and Drugs@FDA
- Synthetic lethality datasets: SynLethDB, BioGRID, SLOrth, MexDrugs