Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis.
Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678)
Interacts with TSPOAP1 (By similarity). May interact with STAR (By similarity). Interacts with MOST-1.
Interacts with TMEM97 (PubMed:37047353). Forms a complex with TMEM97 and PGRMC1; the interaction occurs in MIA PaCa-2 cells but not in MCF7 cells (PubMed:37047353)
Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids
Click a pathway to open the interactive Reactome viewer.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to TSPO, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 1
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT06467773 | Central Nervous System Diseases | TSPO-PET/MRI in Surveillance of Neuroinflammation in the Central Nervous System | N/A | RECRUITING |
| NCT05615415 | Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 Infection | Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 (PASC) Using TSPO Positron Emission Tomography (PET) and MRI | N/A | ACTIVE_NOT_RECRUITING |
| NCT02181582 | Baseline, Blocking Receptor Binding | Specific PET Radioligand Binding to Translocator Protein | PHASE1 | COMPLETED |
| NCT07362290 | Healthy Volunteers - Male and Female | TSPO Occupancy in the Human Lung | NA | ENROLLING_BY_INVITATION |
| NCT03662750 | Stroke, Ischemic, Inflammatory Response, Stroke, Acute | TSPO PET as a Measure of Post-stroke Brain Inflammation: a Natural History Cohort | NA | COMPLETED |
| NCT06398392 | Dosimetry, Healthy | Radiation Dosimetry of the 18 kDa Translocator Protein Ligand [18F]PBR111 in Humans | NA | COMPLETED |
| NCT02147392 | Pharmacokinetics, Adult | Assessment of [11C]ER176 to Image Translocator Protein in Brain and Whole Body of Healthy People | EARLY_PHASE1 | COMPLETED |
| NCT03801629 | Drug Effect | Neuroimmune Effects of Opioid Administration | PHASE1 | COMPLETED |
| NCT01265472 | Squamous Cell Carcinoma, Basal Cell Carcinoma | Comparison of Translocator Protein Expression and Binding Activity in Normal Tissue Versus Non Melanotic Malignancy | N/A | UNKNOWN |
| NCT03958630 | Dementia | PET Imaging of Neuroinflammation in Neurodegenerative Diseases Via a Novel Translocator Protein (TSPO) Radioligand | PHASE1 | TERMINATED |