Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia-mediated cell death (By similarity)
Homodimer; disulfide-linked (By similarity). Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (PubMed:26503042).
Interacts with isoform 2 of BSG (PubMed:25825981). Interacts with CD82; this interaction inhibits VEGFA-mediated signaling pathway (PubMed:34530889)
Higher expression in pituitary tumors than the pituitary gland
Widely expressed
Widely expressed
Widely expressed
Not widely expressed
Not widely expressed
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults.
It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Click a pathway to open the interactive Reactome viewer.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to VEGFA, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 384
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT04902690 | Multiple Sclerosis Relapse | The Possible Neuroprotective Effect of Ocrelizumab Via VEGF Protein Expression in Relapsing Multiple Sclerosis Patients | N/A | UNKNOWN |
| NCT06542796 | Hepatocellular Carcinoma, Immunotherapy | Study on the Classification of Comprehensive Treatment Effect of Hepatocellular Carcinoma | NA | RECRUITING |
| NCT00659555 | Macular Degeneration | Study Of The Repeat Dosing Of Ketoconazole On The Pharmacokinetics Of A Single Dose Of Pazopanib (GW786034) Eye Drops | PHASE1 | COMPLETED |
| NCT00728598 | Proliferative Diabetic Retinopathy, Angiogenesis | Fractalkine, a CX3C Chemokine, Act as a Mediator of Ocular Angiogenesis | N/A | COMPLETED |
| NCT01249521 | Metastatic Colorectal Cancer | Dual Targeting of Vascular Endothelial Growth Factor-A Together With Angiopoietins in Chemotherapy-naïve Metastatic Colorectal Cancer | PHASE2 | UNKNOWN |
| NCT02606019 | Dengue | The Use of Biomarkers in Predicting Dengue Outcome | N/A | UNKNOWN |
| NCT04970251 | Intraocular Pressure, Neovascular Glaucoma, Vascular Endothelial Growth Factor Overexpression, Glaucoma Secondary to Eye Inflammation | Aflibercept as Adjunctive Treatment for Filtration Surgery in Neovascular Glaucoma | NA | COMPLETED |
| NCT00216814 | Bladder Cancer | Antiangiogenic Effects of BCG on Urinary Concentration of Angiogenic Factors | N/A | TERMINATED |
| NCT04964089 | Wet Age-related Macular Degeneration | A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD) | PHASE3 | COMPLETED |
| NCT06243406 | Choroidal Neovascularization | Study on the Biomarkers of Anti-VEGF Treatment for Choroidal Neovascularization | N/A | UNKNOWN |