Drugs that target a gene either directly (oncogene) or via a synthetic-lethal partner (SLP) of a mutated tumour suppressor (TSG). Cell colour shows the strongest known status of that drug for that cancer subtype: approved clinical trial repositionable (potential reuse, no evidence yet) or blank.
| Drug | TSG | SLP (drug target) | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | # |
|---|---|---|---|---|---|---|---|---|---|---|
| sunitinib | TOP1 | PDGFRA | 7 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | TOP1 | PDGFRA | 4 | |||||||
| regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) | TOP1 | PDGFRA | 4 | |||||||
| trastuzumab emtansine | TOP1 | ERBB2 | 7 | |||||||
| tucatinib | TOP1 | ERBB2 | 7 | |||||||
| ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine | TOP1 | TYMS | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | TOP1 | WEE1 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | TOP1 | PDGFRA | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | TOP1 | ERBB2 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | TOP1 | CDK4 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | TOP1 | LCK | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | TOP1 | MST1R | 3 | |||||||
| afatinib | TOP1 | ERBB2 | 3 | |||||||
| capecitabine, cisplatin | TOP1 | TYMS | 3 | |||||||
| crizotinib | TOP1 | MST1R | 3 | |||||||
| dec-205/ny-eso-1 fusion protein cdx-1401, laboratory biomarker analysis, pharmacological study, sirolimus | TOP1 | MTOR | 3 | |||||||
| gemcitabine | TOP1 | TYMS | 3 | |||||||
| mrtx849, pembrolizumab, cetuximab, afatinib | TOP1 | ERBB2 | 3 | |||||||
| pembrolizumab, belzutifan, lenvatinib | TOP1 | PDGFRA | 3 | |||||||
| srf617, gemcitabine, albumin-bound paclitaxel, pembrolizumab | TOP1 | TYMS | 3 | |||||||
| abemaciclib | TOP1 | CDK4 | 7 | |||||||
| capecitabine | TOP1 | TYMS | 7 | |||||||
| everolimus | TOP1 | MTOR | 7 | |||||||
| lapatinib | TOP1 | ERBB2 | 7 | |||||||
| nintedanib | TOP1 | PDGFRA | 7 | |||||||
| palbociclib | TOP1 | CDK4 | 7 | |||||||
| pazopanib | TOP1 | PDGFRA | 7 | |||||||
| regorafenib | TOP1 | PDGFRA | 7 | |||||||
| 5-fu, atezolizumab, bevacizumab, gemcitabine, leucovorin, nab-paclitaxel, oxaliplatin, capecitabine, cisplatin | TOP1 | TYMS | 2 | |||||||
| ab598, zimberelimab, fluorouracil, leucovorin, oxaliplatin | TOP1 | TYMS | 2 | |||||||
| adavosertib, radiation therapy | TOP1 | WEE1 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | TOP1 | TYMS | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | TOP1 | ERBB2 | 2 | |||||||
| alvocidib, paclitaxel | TOP1 | CDK4 | 2 | |||||||
| asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan | TOP1 | TYMS | 2 | |||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | TOP1 | TYMS | 2 | |||||||
| avelumab, lorlatanib, talazoparib, pemetrexed, axitinib, cmp 001, utomilumab, pf04518600 | TOP1 | TYMS | 2 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | TOP1 | TYMS | 2 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | TOP1 | LCK | 2 | |||||||
| bevacizumab, oxaliplatin, leucovorin calcium, fluorouracil, therapeutic conventional surgery, laboratory biomarker analysis | TOP1 | TYMS | 2 | |||||||
| binimetinib, biopsy, biospecimen collection, bone scan, computed tomography, magnetic resonance imaging, palbociclib | TOP1 | CDK4 | 2 | |||||||
| biospecimen collection, computed tomography, devimistat, fluorouracil, gemcitabine hydrochloride, hydroxychloroquine, magnetic resonance imaging | TOP1 | TYMS | 2 | |||||||
| biospecimen collection, computed tomography, pemetrexed | TOP1 | TYMS | 2 | |||||||
| bryostatin 1, paclitaxel | TOP1 | PRKCA | 2 | |||||||
| capecitabine, carboplatin, epirubicin hydrochloride | TOP1 | TYMS | 2 | |||||||
| capecitabine, docetaxel | TOP1 | TYMS | 2 | |||||||
| capecitabine, irinotecan hydrochloride | TOP1 | TYMS | 2 | |||||||
| capecitabine, oxaliplatin | TOP1 | TYMS | 2 | |||||||
| capecitabine, oxaliplatin, gene expression analysis, microarray analysis, reverse transcriptase-polymerase chain reaction, adjuvant therapy, biopsy, conventional surgery, neoadjuvant therapy, quality-of-life assessment, radiation therapy | TOP1 | TYMS | 2 | |||||||
| capecitabine, temozolomide | TOP1 | TYMS | 2 | |||||||
| carboplatin, celecoxib, paclitaxel, adjuvant therapy, conventional surgery, neoadjuvant therapy | TOP1 | NEU1 | 2 | |||||||
| carboplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy | TOP1 | TYMS | 2 | |||||||
| cetuximab, cisplatin, fluorouracil, conventional surgery | TOP1 | TYMS | 2 | |||||||
| chemotherapy, cisplatin, fluorouracil, low-let electron therapy, low-let photon therapy | TOP1 | TYMS | 2 | |||||||
| cisplatin, fluorouracil, conventional surgery, neoadjuvant therapy, radiation therapy | TOP1 | TYMS | 2 | |||||||
| cisplatin, fluorouracil, iressa, conventional surgery, radiation therapy | TOP1 | TYMS | 2 | |||||||
| cisplatin, fluorouracil, paclitaxel, conventional surgery, neoadjuvant therapy, radiation therapy | TOP1 | TYMS | 2 | |||||||
| cisplatin, fluorouracil, paclitaxel, surgical procedure, radiation therapy | TOP1 | TYMS | 2 | |||||||
| cisplatin, fluorouracil, surgical procedure, radiation therapy | TOP1 | TYMS | 2 | |||||||
| cisplatin, pemetrexed, gemcitabine, carboplatin, certolizumab, nivolumab | TOP1 | TYMS | 2 | |||||||
| cixutumumab, everolimus, laboratory biomarker analysis, octreotide acetate, pharmacological study | TOP1 | MTOR | 2 | |||||||
| cpt- 11, cisplatin, celecoxib, radiation, surgery | TOP1 | NEU1 | 2 | |||||||
| durvalumab, tremelimumab, oxaliplatin, capecitabine, radiotherapy, paclitaxel, carboplatin, 5-fluorouracil (5-fu), leucovorin, docetaxel | TOP1 | TYMS | 2 | |||||||
| eft226, sotorasib, fulvestrant, abemaciclib, trastuzumab | TOP1 | ERBB2 | 2 | |||||||
| eft226, sotorasib, fulvestrant, abemaciclib, trastuzumab | TOP1 | CDK4 | 2 | |||||||
| entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib | TOP1 | ERBB2 | 2 | |||||||
| erlotinib hydrochloride, oxaliplatin, fluorouracil, radiation therapy, conventional surgery, immunohistochemistry staining method, positron emission tomography, computed tomography, laboratory biomarker analysis, gene expression analysis, fludeoxyglucose f 18 | TOP1 | TYMS | 2 | |||||||
| filgrastim, cisplatin, fluorouracil, paclitaxel, radiation therapy | TOP1 | TYMS | 2 | |||||||
| filgrastim, pegfilgrastim, cisplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy | TOP1 | TYMS | 2 | |||||||
| fluorouracil, gemcitabine hydrochloride, leucovorin calcium | TOP1 | TYMS | 2 | |||||||
| fluorouracil, irinotecan hydrochloride, leucovorin calcium, pharmacogenomic studies, pharmacological study | TOP1 | TYMS | 2 | |||||||
| fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study | TOP1 | TYMS | 2 | |||||||
| fluorouracil, oxaliplatin, conventional surgery, radiation therapy | TOP1 | TYMS | 2 | |||||||
| gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a | TOP1 | PDGFRA | 2 | |||||||
| inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide | TOP1 | TYMS | 2 | |||||||
| ioa-244, avelumab injection, pemetrexed, cisplatin, ruxolitinib | TOP1 | TYMS | 2 | |||||||
| irinotecan, capecitabine | TOP1 | TYMS | 2 | |||||||
| ksq-001ex, interleukin-2, cyclophosphamide, fludarabine | TOP1 | DCK | 2 | |||||||
| laboratory biomarker analysis, oxaliplatin, pralatrexate | TOP1 | TYMS | 2 | |||||||
| lenvatinib, pembrolizumab | TOP1 | PDGFRA | 2 | |||||||
| lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate | TOP1 | PDGFRA | 2 | |||||||
| ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab | TOP1 | TYMS | 2 | |||||||
| m6620, cisplatin, capecitabine, radiotherapy | TOP1 | TYMS | 2 | |||||||
| mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed | TOP1 | TYMS | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | TOP1 | TYMS | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | TOP1 | PDGFRA | 2 | |||||||
| motexafin gadolinium, radiation therapy | TOP1 | RRM2 | 2 | |||||||
| nab-paclitaxel, gemcitabine | TOP1 | TYMS | 2 | |||||||
| nintedanib | TOP1 | LCK | 2 | |||||||
| nintedanib, pembrolizumab | TOP1 | PDGFRA | 2 | |||||||
| nintedanib, pembrolizumab | TOP1 | LCK | 2 | |||||||
| ociperlimab, tislelizumab, pemetrexed, paclitaxel, nab paclitaxel, carboplatin, cisplatin, etoposide, 5fluorouracil, oxaliplatin, capecitabine | TOP1 | TYMS | 2 | |||||||
| oleclumab, durvalumab, gemcitabine, nab-paclitaxel, oxaliplatin, folinic acid, 5-fu | TOP1 | TYMS | 2 | |||||||
| oxaliplatin, irinotecan hydrochloride, leucovorin calcium, fluorouracil, laboratory biomarker analysis | TOP1 | TYMS | 2 | |||||||
| pembrolizumab, lenvatinib | TOP1 | PDGFRA | 2 | |||||||
| pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu | TOP1 | TYMS | 2 | |||||||
| pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu | TOP1 | PDGFRA | 2 | |||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | TOP1 | TYMS | 2 | |||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | TOP1 | PDGFRA | 2 | |||||||
| pemetrexed, bevacizumab | TOP1 | TYMS | 2 | |||||||
| pralatrexate, docetaxel, fludeoxyglucose f 18, positron emission tomography | TOP1 | TYMS | 2 | |||||||
| radiotherapy targeted to the primary lesion, radiotherapy targeted to the metastatic lesions, anti-pd-1 monoclonal antibody, trastuzumab, chemotherapy, r0 total/subtotal gastrectomy with d2 lymphadenectomy, metastasectomy, local ablative therapies | TOP1 | ERBB2 | 2 | |||||||
| regorafenib, laboratory biomarker analysis | TOP1 | PDGFRA | 2 | |||||||
| sar444881, pembrolizumab, cetuximab, carboplatin, pemetrexed | TOP1 | TYMS | 2 | |||||||
| sy-5609, fulvestrant, gemcitabine, nab-paclitaxel | TOP1 | TYMS | 2 | |||||||
| temsirolimus | TOP1 | MTOR | 2 | |||||||
| temsirolimus, laboratory biomarker analysis | TOP1 | MTOR | 2 | |||||||
| tislelizumab, pemetrexed | TOP1 | TYMS | 2 | |||||||
| trastuzumab | TOP1 | ERBB2 | 2 | |||||||
| trastuzumab, abt-806, bemarituzumab, ramucirumab, nivolumab, standard cytotherapy | TOP1 | ERBB2 | 2 | |||||||
| trastuzumab, tipifarnib | TOP1 | ERBB2 | 2 | |||||||
| whole brain low dose radiotherapy, pemetrexed, sintilimab, chemotherapy | TOP1 | TYMS | 2 | |||||||
| pemetrexed | TOP1 | TYMS | 7 | |||||||
| ribociclib | TOP1 | CDK4 | 7 | |||||||
| rosuvastatin | TOP1 | HMGCR | 7 | |||||||
| trilaciclib | TOP1 | CDK4 | 7 | |||||||
| 2b3-101, trastuzumab, 2b3-101 60 mg/m2 every 4 weeks, 2b3-101 50 mg/m2 every 3 weeks | TOP1 | ERBB2 | 1 | |||||||
| 3-dimensional conformal radiation therapy, bevacizumab, cisplatin, fluorouracil, intensity-modulated radiation therapy | TOP1 | TYMS | 1 | |||||||
| 3-dimensional conformal radiation therapy, biospecimen collection, capecitabine, chemotherapy, computed tomography, erlotinib hydrochloride, fluorouracil, gemcitabine hydrochloride, intensity-modulated radiation therapy, magnetic resonance imaging, quality-of-life assessment, x-ray imaging | TOP1 | TYMS | 1 | |||||||
| 3-dimensional conformal radiation therapy, motexafin gadolinium, temozolomide | TOP1 | RRM2 | 1 | |||||||
| 4-dimensional computed tomography, fluorouracil, gemcitabine hydrochloride, laboratory biomarker analysis, leucovorin calcium, nelfinavir mesylate, oregovomab, stereotactic body radiation therapy, therapeutic conventional surgery | TOP1 | TYMS | 1 | |||||||
| 5-fu, leucovorin, docetaxel, oxaliplatin (flot), trastuzumab, post-operative treatment trastuzumab mono therapy | TOP1 | ERBB2 | 1 | |||||||
| 6,8-bis(benzylthio)octanoic acid, oxaliplatin, leucovorin calcium, irinotecan hydrochloride, fluorouracil, laboratory biomarker analysis | TOP1 | TYMS | 1 | |||||||
| 7-hydroxystaurosporine, fluorouracil | TOP1 | TYMS | 1 | |||||||
| 9-ing-41, retifanlimab, gemcitabine, abraxane | TOP1 | TYMS | 1 | |||||||
| abbv-400, budigalimab, fluorouracil, leucovorin, oxaliplatin | TOP1 | TYMS | 1 | |||||||
| abemaciclib, abemaciclib | TOP1 | CDK4 | 1 | |||||||
| abemaciclib, bevacizumab | TOP1 | CDK4 | 1 | |||||||
| abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf | TOP1 | CDK4 | 1 | |||||||
| abemaciclib, ly3023414, gemcitabine, capecitabine | TOP1 | TYMS | 1 | |||||||
| abemaciclib, ly3023414, gemcitabine, capecitabine | TOP1 | CDK4 | 1 | |||||||
| abemaciclib, ly3214996 | TOP1 | CDK4 | 1 | |||||||
| abemaciclib, surgery | TOP1 | CDK4 | 1 | |||||||
| abraxane (nab-paclitaxel), gemcitabine | TOP1 | TYMS | 1 | |||||||
| adavosertib | TOP1 | WEE1 | 1 | |||||||
| adavosertib, laboratory biomarker analysis, pharmacological study, radiation therapy | TOP1 | WEE1 | 1 | |||||||
| adavosertib, radiation therapy, temozolomide | TOP1 | WEE1 | 1 | |||||||
| adct-601, gemcitabine | TOP1 | TYMS | 1 | |||||||
| adebrelimab, apatinib, tegafur | TOP1 | TYMS | 1 | |||||||
| adjuvant therapy, temozolomide, valproic acid, radiation therapy | TOP1 | CDKN1A | 1 | |||||||
| adriamycin, cyclophosphamide, vindesine, valproic acid | TOP1 | CDKN1A | 1 | |||||||
| aee788, everolimus | TOP1 | MTOR | 1 | |||||||
| afatinib dimaleate, capecitabine, laboratory biomarker analysis | TOP1 | TYMS | 1 | |||||||
| afatinib, biopsy, biospecimen collection, computed tomography, echocardiography, magnetic resonance imaging, radionuclide imaging | TOP1 | ERBB2 | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | TOP1 | ERBB2 | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | TOP1 | MTOR | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | TOP1 | CDK4 | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | TOP1 | LCK | 1 | |||||||
| afatinib, docetaxel, radiation therapy | TOP1 | ERBB2 | 1 | |||||||
| afatinib, gefitinib | TOP1 | ERBB2 | 1 | |||||||
| afatinib, irinotecan | TOP1 | ERBB2 | 1 | |||||||
| ag-013736, gemcitabine, gemcitabine, placebo | TOP1 | TYMS | 1 | |||||||
| agen1423, botensilimab, gemcitabine, nab-paclitaxel | TOP1 | TYMS | 1 | |||||||
| ags-1c4d4, gemcitabine | TOP1 | TYMS | 1 | |||||||
| ak104, ak104, gemcitabine, nab-paclitaxel | TOP1 | TYMS | 1 | |||||||
| ak104, oxaliplatin, capecitabine | TOP1 | TYMS | 1 | |||||||
| ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, nab-paclitaxel, gemcitabine, nab-paclitaxel, gemcitabine | TOP1 | TYMS | 1 | |||||||
| akt inhibitor mk2206, fluorouracil, oxaliplatin, selumetinib | TOP1 | TYMS | 1 | |||||||
| albumin-bound paclitaxel (abi-007), gemcitabine | TOP1 | TYMS | 1 | |||||||
| aldesleukin, antibody therapy, fluorouracil, gemcitabine hydrochloride, irinotecan hydrochloride, laboratory biomarker analysis, leucovorin calcium, oxaliplatin, paclitaxel albumin-stabilized nanoparticle formulation, sargramostim | TOP1 | TYMS | 1 | |||||||
| aldesleukin, biopsy, biospecimen collection, computed tomography, cyclophosphamide, excisional biopsy, fludarabine, magnetic resonance imaging, standard treatment, therapeutic tumor infiltrating lymphocytes | TOP1 | DCK | 1 | |||||||
| alisertib, gemcitabine | TOP1 | TYMS | 1 | |||||||
| alpelisib, everolimus, exemestane | TOP1 | MTOR | 1 | |||||||
| alvocidib, docetaxel | TOP1 | CDK4 | 1 | |||||||
| alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis | TOP1 | CDK4 | 1 | |||||||
| amg 193, gemcitabine, nab-paclitaxel, modified folfirinox | TOP1 | TYMS | 1 | |||||||
| amg 386 placebo, amg 386 10mg/kg, amg 386 3mg/kg, cisplatin, capecitabine, cisplatin, capecitabine, cisplatin, capecitabine | TOP1 | TYMS | 1 | |||||||
| amg 479, placebo, amg 479, gemcitabine | TOP1 | TYMS | 1 | |||||||
| aminolevulinic acid | TOP1 | ALAD | 1 | |||||||
| aminolevulinic acid, surgical resection | TOP1 | ALAD | 1 | |||||||
| andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel | TOP1 | TYMS | 1 | |||||||
| apg-1387 for injection, gemcitabine, nab paclitaxel | TOP1 | TYMS | 1 | |||||||
| apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib | TOP1 | MTOR | 1 | |||||||
| apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib | TOP1 | CDK4 | 1 | |||||||
| aprepitant, gemcitabine hydrochloride, capecitabine, fluorouracil, radiation therapy, questionnaire administration, quality-of-life assessment, nausea and vomiting therapy, management of therapy complications | TOP1 | TYMS | 1 | |||||||
| apx005m, nivolumab, nab-paclitaxel, gemcitabine | TOP1 | TYMS | 1 | |||||||
| arq 197, gemcitabine | TOP1 | TYMS | 1 | |||||||
| arsenic trioxide | TOP1 | CDKN1A | 1 | |||||||
| arsenic trioxide, radiation therapy | TOP1 | CDKN1A | 1 | |||||||
| arsenic trioxide, temozolomide, adjuvant therapy, intensity-modulated radiation therapy, radiation therapy | TOP1 | CDKN1A | 1 | |||||||
| ascorbate, nab paclitaxel, gemcitabine | TOP1 | TYMS | 1 | |||||||
| ascorbic acid, paclitaxel protein-bound, cisplatin, gemcitabine | TOP1 | TYMS | 1 | |||||||
| ascorbic acid, paclitaxel protein-bound, cisplatin, gemcitabine | TOP1 | DBH | 1 | |||||||
| askb589, oxaliplatin, capecitabine, tislelizumab, placebo | TOP1 | TYMS | 1 | |||||||
| atezolizumab, biospecimen collection, capecitabine, computed tomography, docetaxel, echocardiography, fluorouracil, leucovorin calcium, lymphadenectomy, magnetic resonance imaging, oxaliplatin, positron emission tomography, surgical procedure | TOP1 | TYMS | 1 | |||||||
| atezolizumab, conventional surgery, fluorouracil, oxaliplatin, tiragolumab | TOP1 | TYMS | 1 | |||||||
| atezolizumab, tivozanib | TOP1 | PDGFRA | 1 | |||||||
| atorvastatin, temozolomide, radiotherapy | TOP1 | HMGCR | 1 | |||||||
| atra, gemcitabine, nab-paclitaxel | TOP1 | TYMS | 1 | |||||||
| autologous mesothelin-specific tcr-t cells, cyclophosphamide, fludarabine, bendamustine | TOP1 | DCK | 1 | |||||||
| avastin (bevacizumab), gemcitabine, radiation therapy | TOP1 | TYMS | 1 | |||||||
| avelumab, oxaliplatin, 5-fluorouracil, leucovorin, capecitabine, best supportive care, oxaliplatin, 5-fluorouracil, leucovorin, capecitabine | TOP1 | TYMS | 1 | |||||||
| azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab | TOP1 | TYMS | 1 | |||||||
| azd0171, durvalumab, gemcitabine, nab-paclitaxel | TOP1 | TYMS | 1 | |||||||
| azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine | TOP1 | TYMS | 1 | |||||||
| azd1775, gemcitabine, nab-paclitaxel | TOP1 | TYMS | 1 | |||||||
| azd6244, dacarbazine, erlotinib, docetaxel, temsirolimus | TOP1 | MTOR | 1 | |||||||
| bbi608, nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, fluorouracil, mm-398 | TOP1 | TYMS | 1 | |||||||
| bendamustine, biopsy, biospecimen collection, computed tomography, cyclophosphamide, echocardiography, fludarabine, leukapheresis, magnetic resonance imaging, multigated acquisition scan, positron emission tomography, t-cell receptor-engineered t-cells | TOP1 | DCK | 1 | |||||||
| bethanechol, gemcitabine, nab-paclitaxel | TOP1 | TYMS | 1 |