Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445)
Homodimer
Click a pathway to open the interactive Reactome viewer.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to ADCK5, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 3
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT06886425 | Myelodysplastic Syndromes (MDS), Leukemia Acute Myeloid - AML | Involvement of CDA and/or dCK Metabolizing Enzymes in the Response to Azacytidine Treatment of Patients With Hematologic Malignancies | NA | RECRUITING |
| NCT05065736 | Metastatic Cancer, Carcinoma, Adenocarcinoma | Using a PET Imaging Agent, 18F-Clofarabine (CFA), to Measure Deoxycytidine Kinase Activity in Metastatic Cancer | EARLY_PHASE1 | RECRUITING |
| NCT01307241 | Acute Lymphoblastic Leukemia., Acute Myeloblastic Leukemia | RFC and MTHFR SNPs & hENT1- dCK Expression as Prognostic Factors in ALL & hENT1- dCK Expression as Prognostic Factors in AML | N/A | UNKNOWN |
| NCT02888301 | Malignant Neoplasm | 18F-Clofarabine PET/CT in Imaging Cancer Patients Before and After Interventions | N/A | TERMINATED |
| NCT03610100 | Pancreatic Acinar Carcinoma, Pancreatic Neoplasms | Acelarin First Line Randomised Pancreatic Study | PHASE2, PHASE3 | SUSPENDED |