Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters
Homotetramer; composed of two disulfide-linked dimers
A form of orthostatic hypotension due to congenital dopamine beta-hydroxylase deficiency. Orthostatic hypotension, also known as postural hypotension, is a finding defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure occurring 3 minutes after a person has risen from supine to standing. Symptoms include dizziness, blurred vision, and sometimes syncope.
ORTHYP1 is an autosomal recessive condition apparent from infancy or early childhood and characterized by low plasma and urinary levels of norepinephrine and epinephrine, and episodic hypoglycemia.
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Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to DBH, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 315
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT01927055 | Symptomatic Neurogenic Orthostatic Hypotension, Parkinson's Disease, Multiple Systems Atrophy, Pure Autonomic Failure, Dopamine Beta Hydroxylase Deficiency | A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy | PHASE3 | TERMINATED |
| NCT00581477 | Autonomic Nervous System Diseases, Orthostatic Hypotension, Dopamine Beta-Hydroxylase Deficiency, Orthostatic Intolerance | Treatment of Orthostatic Hypotension | PHASE2, PHASE3 | TERMINATED |
| NCT00659230 | Posttraumatic Stress Disorder | Nepicastat for Posttraumatic Stress Disorder (PTSD) in OIF/OEF Veterans | PHASE2 | COMPLETED |
| NCT02586623 | Symptomatic Neurogenic Orthostatic Hypotension | Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension | PHASE4 | COMPLETED |
| NCT01828489 | Pediatric Acute Myeloblastic Leukemia | Research Study for Treatment of Children and Adolescents With Acute Myeloid Leukaemia 0-18 Years | PHASE3 | UNKNOWN |
| NCT00395850 | Cocaine Dependence | Disulfiram for Cocaine Abuse | PHASE2 | COMPLETED |
| NCT00782340 | Symptomatic Neurogenic Orthostatic Hypotension (NOH), Non-diabetic Neuropathy, Primary Autonomic Failure, Dopamine Beta Hydroxylase Deficiency | A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa | PHASE3 | COMPLETED |
| NCT00149630 | Cocaine Dependence, Opioid Dependence | Pharmacogenetics of Disulfiram for Cocaine | PHASE2 | COMPLETED |
| NCT00889135 | Dopamine Beta Hydroxylase (DBH) Deficiency | Long Term Treatment With L-DOPS | N/A | APPROVED_FOR_MARKETING |
| NCT00913484 | Cocaine Dependence, Opioid Dependency | Disulfiram for Cocaine Abuse in Buprenorphine Treatment | PHASE2 | COMPLETED |