Drug × Cancer matrix

Drugs that target a gene either directly (oncogene) or via a synthetic-lethal partner (SLP) of a mutated tumour suppressor (TSG). Cell colour shows the strongest known status of that drug for that cancer subtype: approved clinical trial repositionable (potential reuse, no evidence yet) or blank.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
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Showing 200 of 764 drug-target rows in SSL view, for TSG = FBXW7.
Drug TSG SLP (drug target) GBM LUAD SCLC LUSC OAC OSCC PDAC #
sunitinib FBXW7 KIT 7
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab FBXW7 KIT 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab FBXW7 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) FBXW7 KIT 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) FBXW7 RET 4
crizotinib FBXW7 ALK 7
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib FBXW7 KIT 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib FBXW7 ALK 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib FBXW7 RET 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib FBXW7 WEE1 3
futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan FBXW7 TOP1MT 3
lurbinectedin, irinotecan FBXW7 TOP1MT 3
nivolumab or pembrolizumab (dependent upon approved indication), metformin, rosiglitazone FBXW7 RXRB 3
pembrolizumab, belzutifan, lenvatinib FBXW7 KIT 3
pembrolizumab, belzutifan, lenvatinib FBXW7 RET 3
avapritinib FBXW7 KIT 7
pazopanib FBXW7 KIT 7
regorafenib FBXW7 KIT 7
regorafenib FBXW7 RET 7
selinexor FBXW7 XPO1 7
adavosertib, radiation therapy FBXW7 WEE1 2
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel FBXW7 ALK 2
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel FBXW7 RET 2
alectinib, stereotactic radiosurgery FBXW7 ALK 2
alvocidib, paclitaxel FBXW7 CDK9 2
alvocidib, paclitaxel FBXW7 CDK1 2
apatinib, irinotecan FBXW7 TOP1MT 2
asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan FBXW7 TOP1MT 2
asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine FBXW7 TOP1MT 2
bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment FBXW7 KIT 2
biospecimen collection, computed tomography, devimistat, fluorouracil, gemcitabine hydrochloride, hydroxychloroquine, magnetic resonance imaging FBXW7 TLR9 2
bortezomib FBXW7 PSMB5 2
bryostatin 1, paclitaxel FBXW7 PRKCE 2
cabozantinib FBXW7 RET 2
cabozantinib, atezolizumab, cabozantinib, cabozantinib FBXW7 RET 2
carboplatin, celecoxib, paclitaxel, adjuvant therapy, conventional surgery, neoadjuvant therapy FBXW7 CA3 2
cetuximab, cisplatin, irinotecan, radiation therapy, surgery FBXW7 TOP1MT 2
cpt- 11, cisplatin, celecoxib, radiation, surgery FBXW7 CA3 2
entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib FBXW7 ALK 2
entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib FBXW7 RET 2
fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study FBXW7 HDAC3 2
gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a FBXW7 KIT 2
gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a FBXW7 RET 2
inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide FBXW7 TOP1MT 2
irinotecan, capecitabine FBXW7 TOP1MT 2
irinotecan, docetaxel FBXW7 TOP1MT 2
laboratory biomarker analysis, oxaliplatin, pralatrexate FBXW7 FPGS 2
lenvatinib, pembrolizumab FBXW7 KIT 2
lenvatinib, pembrolizumab FBXW7 RET 2
lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate FBXW7 KIT 2
lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate FBXW7 RET 2
ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab FBXW7 TOP1MT 2
melphalan, bcnu, vitamin b12b, vitamin c, ethanol, autologous hematopoietic stem cells FBXW7 CHRNB4 2
mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a FBXW7 KIT 2
mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a FBXW7 RET 2
motexafin gadolinium, radiation therapy FBXW7 TXNRD1 2
ociperlimab, tislelizumab, pemetrexed, paclitaxel, nab paclitaxel, carboplatin, cisplatin, etoposide, 5fluorouracil, oxaliplatin, capecitabine FBXW7 TOP2A 2
olaparib FBXW7 PARP3 2
pembrolizumab, guadecitabine, mocetinostat FBXW7 HDAC3 2
pembrolizumab, lenvatinib FBXW7 KIT 2
pembrolizumab, lenvatinib FBXW7 RET 2
pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu FBXW7 KIT 2
pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu FBXW7 RET 2
pembrolizumab, paclitaxel, docetaxel, irinotecan FBXW7 TOP1MT 2
pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin FBXW7 KIT 2
pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin FBXW7 RET 2
pralatrexate, docetaxel, fludeoxyglucose f 18, positron emission tomography FBXW7 FPGS 2
quality-of-life assessment, questionnaire administration, selpercatinib, therapeutic conventional surgery FBXW7 RET 2
regorafenib, laboratory biomarker analysis FBXW7 KIT 2
regorafenib, laboratory biomarker analysis FBXW7 RET 2
rituximab FBXW7 MS4A1 2
sorafenib, administered orally, ct/mri FBXW7 KIT 2
sorafenib, administered orally, ct/mri FBXW7 RET 2
topotecan FBXW7 TOP1MT 2
arsenic trioxide FBXW7 TXNRD1 7
carfilzomib FBXW7 PSMB5 7
carfilzomib FBXW7 PSMB2 7
selpercatinib FBXW7 RET 7
sorafenib FBXW7 KIT 7
sorafenib FBXW7 RET 7
vandetanib FBXW7 RET 7
18f-fluoromisonidazole, cediranib maleate, laboratory biomarker analysis, olaparib, positron emission tomography FBXW7 PARP3 1
3-dimensional conformal radiation therapy, cognitive assessment, laboratory biomarker analysis, temozolomide, vorinostat FBXW7 HDAC3 1
3-dimensional conformal radiation therapy, intensity-modulated radiation therapy (imrt), temozolomide, chloroquine, tumor treating fields therapy (ttf) FBXW7 TLR9 1
3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, vorinostat FBXW7 HDAC3 1
3-dimensional conformal radiation therapy, motexafin gadolinium, temozolomide FBXW7 TXNRD1 1
5 fluorouracil, leucovorin, irinotecan, oxaliplatin FBXW7 TOP1MT 1
9-ing-41, gemcitabine - 21 day cycle, doxorubicin., lomustine, carboplatin., nab paclitaxel., paclitaxel., gemcitabine - 28 day cycle, irinotecan FBXW7 TOP1MT 1
abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf FBXW7 TOP1MT 1
acetazolamide, temozolomide FBXW7 CA3 1
acetazolamide, temozolomide FBXW7 CA14 1
actidose aqua, artesunate, amodiaquine FBXW7 HNMT 1
adavosertib FBXW7 WEE1 1
adavosertib, laboratory biomarker analysis, pharmacological study, radiation therapy FBXW7 WEE1 1
adavosertib, radiation therapy, temozolomide FBXW7 WEE1 1
adebrelimab injection, apatinib mesylate tablets, carboplatin, cisplatin, etoposide FBXW7 TOP2A 1
adebrelimab, apatinib mesylate, etoposide, carboplatin FBXW7 TOP2A 1
adebrelimab, carboplatin/cisplatin, etoposide, radiation therapy FBXW7 TOP2A 1
adebrelimab, radiation therapy, etoposide, carboplatin(ec) FBXW7 TOP2A 1
afatinib, dasatinib, palbociclib, everolimus, olaparib FBXW7 PARP3 1
afatinib, dasatinib, palbociclib, everolimus, olaparib FBXW7 KIT 1
afatinib, irinotecan FBXW7 TOP1MT 1
aldoxorubicin, topotecan FBXW7 TOP1MT 1
aldoxorubicin, topotecan FBXW7 TOP2A 1
alvocidib, docetaxel FBXW7 CDK9 1
alvocidib, docetaxel FBXW7 CDK1 1
alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis FBXW7 CDK9 1
alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis FBXW7 CDK1 1
amifostine trihydrate, cisplatin, etoposide, radiation therapy FBXW7 TOP2A 1
aminolevulinic acid FBXW7 ALAD 1
aminolevulinic acid, surgical resection FBXW7 ALAD 1
amrubicin FBXW7 TOP2A 1
amrubicin, cisplatin, etoposide FBXW7 TOP2A 1
amrubicin, topotecan FBXW7 TOP1MT 1
amrubicin, topotecan FBXW7 TOP2A 1
andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel FBXW7 TOP1MT 1
anti-igf-1r recombinant monoclonal antibody mk-0646, cisplatin, etoposide FBXW7 TOP2A 1
apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib FBXW7 ALK 1
arsenic trioxide, radiation therapy FBXW7 TXNRD1 1
arsenic trioxide, temozolomide, adjuvant therapy, intensity-modulated radiation therapy, radiation therapy FBXW7 TXNRD1 1
ascorbic acid, paclitaxel protein-bound, cisplatin, gemcitabine FBXW7 EGLN3 1
at-101, topotecan FBXW7 TOP1MT 1
atezolizumab, cabozantinib FBXW7 RET 1
atezolizumab, carboplatin, etoposide FBXW7 TOP2A 1
atezolizumab, tivozanib FBXW7 KIT 1
atorvastatin, temozolomide, radiotherapy FBXW7 NR1I3 1
autologous dendritic cell-adenovirus p53 vaccine, carboplatin, etoposide FBXW7 TOP2A 1
avapritinib, midazolam FBXW7 KIT 1
avastin, bortezomib FBXW7 PSMB5 1
avastin, temozolomide, irinotecan FBXW7 TOP1MT 1
avastin, temozolomide, radiation therapy (xrt), irinotecan FBXW7 TOP1MT 1
avelumab, irinotecan, paclitaxel, best supportive care (bsc) FBXW7 TOP1MT 1
azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab FBXW7 HDAC3 1
azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab FBXW7 MS4A1 1
azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine FBXW7 TOP1MT 1
azd1775, olaparib FBXW7 PARP3 1
bbi608, nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, fluorouracil, mm-398 FBXW7 TOP1MT 1
becatecarin FBXW7 TOP2A 1
belinostat, cisplatin, etoposide FBXW7 TOP2A 1
belotecan, etoposide, cisplatin FBXW7 TOP2A 1
bemarituzumab, paclitaxel, ramucirumab, bemarituzumab, irinotecan, bemarituzumab, trifluridine/tipiracil FBXW7 TOP1MT 1
berzosertib, computed tomography assisted biopsy, endoscopic biopsy, irinotecan, magnetic resonance imaging FBXW7 TOP1MT 1
bevacizumab [avastin], fotemustine FBXW7 TXNRD1 1
bevacizumab [avastin], irinotecan, temozolomide FBXW7 TOP1MT 1
bevacizumab, cediranib, cediranib maleate, olaparib FBXW7 PARP3 1
bevacizumab, cisplatin, etoposide, radiation therapy FBXW7 TOP2A 1
bevacizumab, dasatinib, placebo FBXW7 KIT 1
bevacizumab, irinotecan FBXW7 TOP1MT 1
bevacizumab, irinotecan, dynamic contrast-enhanced magnetic resonance imaging FBXW7 TOP1MT 1
bevacizumab, temozolomide, radiation therapy (xrt), topotecan FBXW7 TOP1MT 1
bevacizumab, temozolomide, vorinostat FBXW7 HDAC3 1
bi 764532, carboplatin, etoposide, atezolizumab, durvalumab, cisplatin FBXW7 TOP2A 1
bi 764532, topotecan, single agent chemotherapy FBXW7 TOP1MT 1
binimetinib, hydroxychloroquine FBXW7 TLR9 1
biopsy, biospecimen collection, computed tomography, echocardiography, magnetic resonance imaging, radionuclide imaging, sunitinib FBXW7 KIT 1
biopsy, biospecimen collection, computed tomography, endoscopic ultrasound, fluorouracil, irinotecan, leucovorin, lymph node biopsy, magnetic resonance imaging, oxaliplatin, pembrolizumab, photodynamic therapy, positron emission tomography, questionnaire administration, verteporfin FBXW7 TOP1MT 1
biopsy, biospecimen collection, computed tomography, erdafitinib, magnetic resonance imaging FBXW7 KIT 1
biopsy, biospecimen collection, computed tomography, erdafitinib, magnetic resonance imaging FBXW7 RET 1
biopsy, biospecimen collection, computed tomography, magnetic resonance imaging, olaparib FBXW7 PARP3 1
biopsy, biospecimen collection, computed tomography, magnetic resonance imaging, olaparib, pembrolizumab FBXW7 PARP3 1
biopsy, biospecimen collection, crizotinib, radiologic examination FBXW7 ALK 1
biopsy, folfirinox, ciprofloxacin, metronidazole, pembrolizumab, surgical resection FBXW7 TOP2A 1
biopsy, magnetic resonance imaging, radiation therapy, selinexor FBXW7 XPO1 1
biospecimen collection, computed tomography, core biopsy, fluorouracil, irinotecan, leucovorin, leucovorin calcium, oxaliplatin, quemliclustat, zimberelimab FBXW7 TOP1MT 1
biospecimen collection, computed tomography, magnetic resonance imaging, olaparib, placebo administration FBXW7 PARP3 1
biospecimen collection, erdafitinib, magnetic resonance imaging, optical coherence tomography FBXW7 KIT 1
biospecimen collection, erdafitinib, magnetic resonance imaging, optical coherence tomography FBXW7 RET 1
biospecimen collection, magnetic resonance imaging, selinexor, temozolomide FBXW7 XPO1 1
bl-b01d1, irinotecan, paclitaxel, docetaxel FBXW7 TOP1MT 1
bl-b01d1, topotecan FBXW7 TOP1MT 1
bms-833923, carboplatin, etoposide FBXW7 TOP2A 1
bms-986012, carboplatin, etoposide, nivolumab FBXW7 TOP2A 1
bms-986012, cisplatin, etoposide FBXW7 TOP2A 1
bms-986012, cisplatin, etoposide, platinum, carboplatin FBXW7 TOP2A 1
bms-986489 (bms-986012+nivolumab), atezolizumab, carboplatin, etoposide FBXW7 TOP2A 1
bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan FBXW7 TOP1MT 1
bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan FBXW7 TOP2A 1
bortezomib, carboplatin, paclitaxel FBXW7 PSMB5 1
bortezomib, gemcitabine hydrochloride FBXW7 PSMB5 1
bortezomib, irinotecan FBXW7 TOP1MT 1
bortezomib, irinotecan FBXW7 PSMB5 1
bortezomib, radiation therapy FBXW7 PSMB5 1
bortezomib, temozolomide, pharmacological study FBXW7 PSMB5 1
botensilimab, balstilimab, chloroquine phosphate, celecoxib FBXW7 CA3 1
cabozantinib, durvalumab, tremelimumab FBXW7 RET 1
cabozantinib, nivolumab FBXW7 RET 1
cabozantinib, pembrolizumab FBXW7 RET 1
camrelizumab, docetaxel, irinotecan FBXW7 TOP1MT 1
camrelizumab, irinotecan, paclitaxel, paclitaxel-albumin, docetaxel, anlotinib FBXW7 TOP1MT 1
capecitabine, carboplatin, cisplatin, etoposide, laboratory biomarker analysis, temozolomide FBXW7 TOP2A 1
capecitabine, cisplatin, epirubicin, gemcitabine FBXW7 TOP2A 1
capecitabine, epirubicin, amg 102, cisplatin, placebo FBXW7 TOP2A 1
capecitabine, medi4736 (durvalumab), trastuzumab, rucaparib, ramucirumab FBXW7 PARP3 1
capecitabine, oxaliplatin, irinotecan FBXW7 TOP1MT 1
capecitabine, vorinostat, radiotherapy, surgery to remove tumor FBXW7 HDAC3 1
carboplatin, atezolizumab, etoposide, total body irradiation, hypofractionated radiation therapy, magnetic resonance imaging FBXW7 TOP2A 1
carboplatin, cisplatin, cyclophosphamide, doxorubicin hydrochloride, etoposide, ifosfamide, mesna, vincristine sulfate, radiation therapy FBXW7 TOP2A 1
carboplatin, cisplatin, docetaxel, etoposide, pembrolizumab FBXW7 TOP2A 1
carboplatin, cisplatin, etoposide, irinotecan hydrochloride, radiation therapy FBXW7 TOP2A 1
carboplatin, cisplatin, etoposide, sintilimab, ibi110 FBXW7 TOP2A 1
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable candidates from cansar.ai — these are potential drug-cancer reuse candidates, not evidence of efficacy.