Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates
Monomer
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Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to FPGS, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
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No clinical trials information available.