Drug × Cancer matrix

Drugs that target a gene either directly (oncogene) or via a synthetic-lethal partner (SLP) of a mutated tumour suppressor (TSG). Cell colour shows the strongest known status of that drug for that cancer subtype: approved clinical trial repositionable (potential reuse, no evidence yet) or blank.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
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Showing 200 of 576 drug-target rows in SSL view, for TSG = EP300.
Drug TSG SLP (drug target) GBM LUAD SCLC LUSC OAC OSCC PDAC #
sunitinib EP300 KIT 7
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab EP300 RET 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab EP300 KIT 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) EP300 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) EP300 KIT 4
crizotinib EP300 ALK 7
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib EP300 ALK 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib EP300 RET 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib EP300 KIT 3
futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan EP300 TOP1MT 3
lurbinectedin, irinotecan EP300 TOP1MT 3
nivolumab or pembrolizumab (dependent upon approved indication), metformin, rosiglitazone EP300 RXRB 3
pembrolizumab, belzutifan, lenvatinib EP300 RET 3
pembrolizumab, belzutifan, lenvatinib EP300 KIT 3
avapritinib EP300 KIT 7
pazopanib EP300 KIT 7
regorafenib EP300 RET 7
regorafenib EP300 KIT 7
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel EP300 ALK 2
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel EP300 RET 2
alectinib, stereotactic radiosurgery EP300 ALK 2
alvocidib, paclitaxel EP300 CDK9 2
apatinib, irinotecan EP300 TOP1MT 2
asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan EP300 TOP1MT 2
asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine EP300 TOP1MT 2
bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment EP300 KIT 2
biospecimen collection, computed tomography, devimistat, fluorouracil, gemcitabine hydrochloride, hydroxychloroquine, magnetic resonance imaging EP300 TLR9 2
bortezomib EP300 PSMB5 2
bryostatin 1, paclitaxel EP300 PRKCE 2
cabozantinib EP300 RET 2
cabozantinib, atezolizumab, cabozantinib, cabozantinib EP300 RET 2
carboplatin, celecoxib, paclitaxel, adjuvant therapy, conventional surgery, neoadjuvant therapy EP300 CA3 2
cetuximab, cisplatin, irinotecan, radiation therapy, surgery EP300 TOP1MT 2
cpt- 11, cisplatin, celecoxib, radiation, surgery EP300 CA3 2
entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib EP300 ALK 2
entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib EP300 RET 2
fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study EP300 HDAC3 2
gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a EP300 RET 2
gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a EP300 KIT 2
inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide EP300 TOP1MT 2
irinotecan, capecitabine EP300 TOP1MT 2
irinotecan, docetaxel EP300 TOP1MT 2
lenvatinib, pembrolizumab EP300 RET 2
lenvatinib, pembrolizumab EP300 KIT 2
lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate EP300 RET 2
lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate EP300 KIT 2
ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab EP300 TOP1MT 2
melphalan, bcnu, vitamin b12b, vitamin c, ethanol, autologous hematopoietic stem cells EP300 CHRNB4 2
mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a EP300 RET 2
mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a EP300 KIT 2
pembrolizumab, guadecitabine, mocetinostat EP300 HDAC3 2
pembrolizumab, lenvatinib EP300 RET 2
pembrolizumab, lenvatinib EP300 KIT 2
pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu EP300 RET 2
pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu EP300 KIT 2
pembrolizumab, paclitaxel, docetaxel, irinotecan EP300 TOP1MT 2
pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin EP300 RET 2
pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin EP300 KIT 2
quality-of-life assessment, questionnaire administration, selpercatinib, therapeutic conventional surgery EP300 RET 2
regorafenib, laboratory biomarker analysis EP300 RET 2
regorafenib, laboratory biomarker analysis EP300 KIT 2
sorafenib, administered orally, ct/mri EP300 RET 2
sorafenib, administered orally, ct/mri EP300 KIT 2
topotecan EP300 TOP1MT 2
carfilzomib EP300 PSMB5 7
rosuvastatin EP300 HMGCR 7
selpercatinib EP300 RET 7
sorafenib EP300 RET 7
sorafenib EP300 KIT 7
vandetanib EP300 RET 7
3-dimensional conformal radiation therapy, cognitive assessment, laboratory biomarker analysis, temozolomide, vorinostat EP300 HDAC3 1
3-dimensional conformal radiation therapy, intensity-modulated radiation therapy (imrt), temozolomide, chloroquine, tumor treating fields therapy (ttf) EP300 TLR9 1
3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, vorinostat EP300 HDAC3 1
5 fluorouracil, leucovorin, irinotecan, oxaliplatin EP300 TOP1MT 1
9-ing-41, gemcitabine - 21 day cycle, doxorubicin., lomustine, carboplatin., nab paclitaxel., paclitaxel., gemcitabine - 28 day cycle, irinotecan EP300 TOP1MT 1
abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf EP300 TOP1MT 1
acetazolamide, temozolomide EP300 CA14 1
acetazolamide, temozolomide EP300 CA3 1
actidose aqua, artesunate, amodiaquine EP300 HNMT 1
afatinib, dasatinib, palbociclib, everolimus, olaparib EP300 KIT 1
afatinib, irinotecan EP300 TOP1MT 1
aldoxorubicin, topotecan EP300 TOP1MT 1
alvocidib, docetaxel EP300 CDK9 1
alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis EP300 CDK9 1
aminolevulinic acid EP300 ALAD 1
aminolevulinic acid, surgical resection EP300 ALAD 1
amrubicin, topotecan EP300 TOP1MT 1
andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel EP300 TOP1MT 1
apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib EP300 ALK 1
ascorbic acid, paclitaxel protein-bound, cisplatin, gemcitabine EP300 EGLN3 1
at-101, topotecan EP300 TOP1MT 1
atezolizumab, cabozantinib EP300 RET 1
atezolizumab, tivozanib EP300 KIT 1
atorvastatin, temozolomide, radiotherapy EP300 NR1I3 1
atorvastatin, temozolomide, radiotherapy EP300 HMGCR 1
avapritinib, midazolam EP300 KIT 1
avastin, bortezomib EP300 PSMB5 1
avastin, temozolomide, irinotecan EP300 TOP1MT 1
avastin, temozolomide, radiation therapy (xrt), irinotecan EP300 TOP1MT 1
avelumab, irinotecan, paclitaxel, best supportive care (bsc) EP300 TOP1MT 1
azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab EP300 HDAC3 1
azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine EP300 TOP1MT 1
bbi608, nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, fluorouracil, mm-398 EP300 TOP1MT 1
bemarituzumab, paclitaxel, ramucirumab, bemarituzumab, irinotecan, bemarituzumab, trifluridine/tipiracil EP300 TOP1MT 1
berzosertib, computed tomography assisted biopsy, endoscopic biopsy, irinotecan, magnetic resonance imaging EP300 TOP1MT 1
bevacizumab [avastin], irinotecan, temozolomide EP300 TOP1MT 1
bevacizumab, dasatinib, placebo EP300 KIT 1
bevacizumab, irinotecan EP300 TOP1MT 1
bevacizumab, irinotecan, dynamic contrast-enhanced magnetic resonance imaging EP300 TOP1MT 1
bevacizumab, temozolomide, radiation therapy (xrt), topotecan EP300 TOP1MT 1
bevacizumab, temozolomide, vorinostat EP300 HDAC3 1
bi 764532, topotecan, single agent chemotherapy EP300 TOP1MT 1
binimetinib, hydroxychloroquine EP300 TLR9 1
biopsy, biospecimen collection, computed tomography, echocardiography, magnetic resonance imaging, radionuclide imaging, sunitinib EP300 KIT 1
biopsy, biospecimen collection, computed tomography, endoscopic ultrasound, fluorouracil, irinotecan, leucovorin, lymph node biopsy, magnetic resonance imaging, oxaliplatin, pembrolizumab, photodynamic therapy, positron emission tomography, questionnaire administration, verteporfin EP300 TOP1MT 1
biopsy, biospecimen collection, computed tomography, erdafitinib, magnetic resonance imaging EP300 RET 1
biopsy, biospecimen collection, computed tomography, erdafitinib, magnetic resonance imaging EP300 KIT 1
biopsy, biospecimen collection, crizotinib, radiologic examination EP300 ALK 1
biospecimen collection, computed tomography, core biopsy, fluorouracil, irinotecan, leucovorin, leucovorin calcium, oxaliplatin, quemliclustat, zimberelimab EP300 TOP1MT 1
biospecimen collection, erdafitinib, magnetic resonance imaging, optical coherence tomography EP300 RET 1
biospecimen collection, erdafitinib, magnetic resonance imaging, optical coherence tomography EP300 KIT 1
bl-b01d1, irinotecan, paclitaxel, docetaxel EP300 TOP1MT 1
bl-b01d1, topotecan EP300 TOP1MT 1
bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan EP300 TOP1MT 1
bortezomib, carboplatin, paclitaxel EP300 PSMB5 1
bortezomib, gemcitabine hydrochloride EP300 PSMB5 1
bortezomib, irinotecan EP300 TOP1MT 1
bortezomib, irinotecan EP300 PSMB5 1
bortezomib, radiation therapy EP300 PSMB5 1
bortezomib, temozolomide, pharmacological study EP300 PSMB5 1
botensilimab, balstilimab, chloroquine phosphate, celecoxib EP300 CA3 1
cabozantinib, durvalumab, tremelimumab EP300 RET 1
cabozantinib, nivolumab EP300 RET 1
cabozantinib, pembrolizumab EP300 RET 1
camrelizumab, docetaxel, irinotecan EP300 TOP1MT 1
camrelizumab, irinotecan, paclitaxel, paclitaxel-albumin, docetaxel, anlotinib EP300 TOP1MT 1
capecitabine, oxaliplatin, irinotecan EP300 TOP1MT 1
capecitabine, vorinostat, radiotherapy, surgery to remove tumor EP300 HDAC3 1
carboplatin, irinotecan EP300 TOP1MT 1
carboxylesterase-expressing allogeneic neural stem cells, irinotecan, irinotecan hydrochloride, laboratory biomarker analysis, pharmacological study EP300 TOP1MT 1
ce-mark approved laa closure devices, acetylsalicylic acid, clopidogrel, dabigatran, rivaroxaban, apixaban, edoxaban, phenprocoumon, warfarin EP300 TP53 1
celecoxib, cyclophosphamide, etoposide, thalidomide EP300 CA3 1
celecoxib, isotretinoin, temozolomide, thalidomide EP300 CA3 1
celecoxib, temozolomide, thalidomide, adjuvant therapy EP300 CA3 1
ceritinib, cisplatin, gemcitabine hydrochloride, laboratory biomarker analysis, paclitaxel albumin-stabilized nanoparticle formulation, pharmacological study EP300 ALK 1
cetuximab, bevacizumab, irinotecan EP300 TOP1MT 1
cetuximab, bortezomib EP300 PSMB5 1
cetuximab, irinotecan, oxaliplatin, uft EP300 TOP1MT 1
chloroquine EP300 TLR9 1
chloroquine, radiotherapy, temozolomide EP300 TLR9 1
cisplatin, fluorouracil, gemcitabine, irinotecan, leucovorin, nab-paclitaxel, oxaliplatin, radiation therapy EP300 TOP1MT 1
cisplatin, gleevec™, irinotecan EP300 TOP1MT 1
cisplatin, irinotecan, capecitabine EP300 TOP1MT 1
cisplatin, pemetrexed disodium, sorafenib EP300 RET 1
cisplatin, pemetrexed disodium, sorafenib EP300 KIT 1
cobimetinib, hydroxychloroquine, atezolizumab EP300 TLR9 1
cyproheptadine hydrochloride, megestrol acetate EP300 PGR 1
dasatinib, erlotinib hydrochloride, gemcitabine hydrochloride EP300 KIT 1
dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis, mutation analysis, nucleic acid sequencing, immunohistochemistry staining method EP300 KIT 1
dasatinib, laboratory biomarker analysis, physiologic testing EP300 KIT 1
dasatinib, mfolfox6 EP300 KIT 1
dasatinib, pharmacological study EP300 KIT 1
dasatinib, temozolomide, placebo, radiation therapy EP300 KIT 1
digoxin, 5fluorouracil, calcium leucovorin, irinotecan, oxaliplatin EP300 TOP1MT 1
durvalumab, oxaliplatin, irinotecan, calcium folinate (leucovorin), fluorouracil, pegylated g-csf EP300 TOP1MT 1
endoscopic variceal ligation, carvedilol EP300 SELE 1
enzastaurin, bevacizumab, enzyme-inducing antiepileptic drugs (eiaed), non-enzyme inducing antiepileptic drugs (neiaed) EP300 CHEK1 1
enzastaurin, lomustine EP300 CHEK1 1
enzastaurin, temozolomide, radiation therapy EP300 CHEK1 1
eras-007, encorafenib, cetuximab, palbociclib EP300 MAPK8 1
eras-007, encorafenib, cetuximab, palbociclib EP300 LIMK2 1
erdafitinib EP300 RET 1
erdafitinib EP300 KIT 1
ethanol, enoxaparin EP300 CHRNB4 1
etomidate, midazolam, meperidine EP300 GRIN2C 1
etomidate, midazolam, meperidine EP300 GRIN2B 1
everolimus, sorafenib EP300 RET 1
everolimus, sorafenib EP300 KIT 1
fluorouracil, irinotecan, irinotecan hydrochloride, leucovorin, leucovorin calcium, nivolumab, oxaliplatin, therapeutic conventional surgery EP300 TOP1MT 1
fluorouracil, leucovorin calcium, oxaliplatin, irinotecan, nivolumab, magnetic resonance imaging, computed tomography, biospecimen collection, questionnaire administration EP300 TOP1MT 1
fluorouracil, oxaliplatin, irinotecan EP300 TOP1MT 1
gemcitabine, abraxane, hydroxychloroquine EP300 TLR9 1
gemcitabine, erlotinib, sorafenib EP300 RET 1
gemcitabine, erlotinib, sorafenib EP300 KIT 1
gemcitabine, hydroxychloroquine, nab-paclitaxel, paricalcitol EP300 TLR9 1
gemcitabine, nab-paclitaxel, irinotecan, intensity-modulated radiation therapy (imrt) EP300 TOP1MT 1
gemcitabine, oxaliplatin, imatinib EP300 RET 1
gemcitabine, oxaliplatin, imatinib EP300 KIT 1
gemcitabine, placebo, sorafenib EP300 RET 1
gemcitabine, placebo, sorafenib EP300 KIT 1
gemcitabine, sorafenib, radiotherapy EP300 RET 1
gemcitabine, sorafenib, radiotherapy EP300 KIT 1
gemcitabine, sorafenib, vorinostat, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, rosettesep, depfff EP300 HDAC3 1
gemcitabine, sorafenib, vorinostat, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, rosettesep, depfff EP300 RET 1
gemcitabine, sorafenib, vorinostat, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, rosettesep, depfff EP300 KIT 1
gemcitabine, sunitinib EP300 KIT 1
gemcitabine, taxotere, xeloda, cisplatin, irinotecan EP300 TOP1MT 1
genistein, erlotinib hydrochloride, gemcitabine hydrochloride EP300 ESRRA 1
h101, tislelizumab, lenvatinib EP300 RET 1
h101, tislelizumab, lenvatinib EP300 KIT 1
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable candidates from cansar.ai — these are potential drug-cancer reuse candidates, not evidence of efficacy.