SELENOM

E-selectin UniProt accession P16581

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis

Source: UniProt

Interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope. SELPLG sulfation appears not to be required for this interaction

Source: UniProt
Cell membrane — Single-pass type I membrane protein
Source: UniProt

Click a pathway to open the interactive Reactome viewer.

Pathway list and interactive viewer: Reactome

Synthetic Lethal Network

Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to SELENOM, aggregated across our SSL data sources. Click any partner node to view that gene’s page.

Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.

BioGRID SLOrth SynLethDB MexDrugs Multi-source
Sources: BioGRID, SLOrth, SynLethDB, MexDrugs

Clinical Trials

Total Trials Found: 1

NCT ID Condition Brief Title Phase Status
NCT06900361 Asthma Self Management Use of Mobile Phone Application for Asthma Sele Management N/A COMPLETED
NCT06962462 Erectile Dysfunction Associated With Type 2 Diabetes Mellitus Daily Tadalafil in Diabetic ED Patients NA NOT_YET_RECRUITING
NCT05312788 Cardiovascular Diseases, Kidney Diseases Effect of Barley Supplemented Wheat Bread on Markers of Cardiovascular and Renal Health NA COMPLETED
NCT00012454 Cerebrovascular Accident, Transient Ischemic Attack E-Selectin Nasal Spray to Prevent Stroke Recurrence PHASE2 TERMINATED
NCT06286098 Hemodialysis Complication, Pediatric Kidney Disease, Cardiovascular Complication Alpha Lipoic Acid in Pediatrics on Hemodialysis PHASE3 ENROLLING_BY_INVITATION
NCT00457171 Ulcerative Colitis GI-270384 Study In Patients With Mild To Moderate Ulcerative Colitis PHASE1 TERMINATED
NCT02306291 Leukemia, Myeloid, Acute Study to Determine Safety, Pharmacokinetics and Efficacy of GMI-1271 in Combination With Chemotherapy in AML PHASE1, PHASE2 COMPLETED
NCT05146739 Acute Myeloid Leukemia Post Cytotoxic Therapy, Myelodysplastic Syndrome Post Cytotoxic Therapy, Myeloid Leukemia Associated With Down Syndrome, Recurrent Acute Myeloid Leukemia, Recurrent Mixed Phenotype Acute Leukemia, Recurrent Myelodysplastic Syndrome, Refractory Acute Myeloid Leukemia, Refractory Mixed Phenotype Acute Leukemia, Refractory Myelodysplastic Syndrome Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory That Expresses E-selectin Ligand on the Cell Membrane PHASE1 ACTIVE_NOT_RECRUITING
NCT00069069 Ischemic Attack, Transient, Transient E-Selectin Nasal Instillation to Prevent Secondary Stroke PHASE1 WITHDRAWN