Drug × Cancer matrix

Drugs that target a gene either directly (oncogene) or via a synthetic-lethal partner (SLP) of a mutated tumour suppressor (TSG). Cell colour shows the strongest known status of that drug for that cancer subtype: approved clinical trial repositionable (potential reuse, no evidence yet) or blank.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
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Showing 200 of 488 drug-target rows in SSL view, for TSG = CYLD.
Drug TSG SLP (drug target) GBM LUAD SCLC LUSC OAC OSCC PDAC #
docetaxel, thalidomide CYLD BCL2 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab CYLD BCL2 4
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib CYLD PIK3CB 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib CYLD CSK 3
amg 193, docetaxel, comparator amg 193 test tablet CYLD BCL2 3
bms-986340, bms-936558-01, docetaxel CYLD BCL2 3
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel CYLD BCL2 2
alvocidib, paclitaxel CYLD BCL2 2
asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan CYLD BCL2 2
bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment CYLD CSK 2
bryostatin 1, paclitaxel CYLD BCL2 2
btla inhibitor (js004), toripalimab, paclitaxel, cisplatin CYLD BCL2 2
capecitabine, docetaxel CYLD BCL2 2
carboplatin, celecoxib, paclitaxel, adjuvant therapy, conventional surgery, neoadjuvant therapy CYLD BCL2 2
carboplatin, docetaxel CYLD BCL2 2
carboplatin, endoscopic biopsy, external beam radiation therapy, lenvatinib mesylate, paclitaxel, pembrolizumab, resection CYLD BCL2 2
carboplatin, esophagectomy, intensity-modulated radiation therapy, paclitaxel, proton beam radiation therapy, quality-of-life assessment, questionnaire administration, folfox regimen, capox regimen, docetaxel, 5fu CYLD BCL2 2
carboplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy CYLD BCL2 2
carboplatin, paclitaxel, panitumumab, radiotherapy CYLD BCL2 2
carboplatin, paclitaxel, radiation therapy, telomerase-specific type 5 adenovirus obp-301 CYLD BCL2 2
carboplatin, paclitaxel, three-dimensional conformal radiation therapy CYLD BCL2 2
cetuximab, cisplatin, docetaxel, adjuvant therapy, neoadjuvant therapy CYLD BCL2 2
chemotherapy, cisplatin, paclitaxel, low-let electron therapy, low-let photon therapy CYLD BCL2 2
cisplatin, docetaxel, irinotecan hydrochloride, radiation therapy CYLD BCL2 2
cisplatin, fluorouracil, paclitaxel, conventional surgery, neoadjuvant therapy, radiation therapy CYLD BCL2 2
cisplatin, fluorouracil, paclitaxel, surgical procedure, radiation therapy CYLD BCL2 2
cisplatin, paclitaxel, surgical procedure, radiation therapy CYLD BCL2 2
cixutumumab, laboratory biomarker analysis, paclitaxel, pharmacological study CYLD BCL2 2
dkn-01 150 mg, paclitaxel, pembrolizumab, dkn-01 300 mg CYLD BCL2 2
docetaxel, 5-fu, radiotherapy, esophagectomy, dexamethasone CYLD BCL2 2
durvalumab, tremelimumab, oxaliplatin, capecitabine, radiotherapy, paclitaxel, carboplatin, 5-fluorouracil (5-fu), leucovorin, docetaxel CYLD BCL2 2
filgrastim, cisplatin, fluorouracil, paclitaxel, radiation therapy CYLD BCL2 2
filgrastim, paclitaxel, topotecan hydrochloride CYLD BCL2 2
filgrastim, pegfilgrastim, cisplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy CYLD BCL2 2
gemcitabine hydrochloride, paclitaxel, tipifarnib, radiation therapy CYLD BCL2 2
irinotecan, docetaxel CYLD BCL2 2
melphalan, bcnu, vitamin b12b, vitamin c, ethanol, autologous hematopoietic stem cells CYLD CACNG1 2
melphalan, bcnu, vitamin b12b, vitamin c, ethanol, autologous hematopoietic stem cells CYLD CHRNA9 2
mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed CYLD BCL2 2
mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a CYLD BCL2 2
ociperlimab, tislelizumab, pemetrexed, paclitaxel, nab paclitaxel, carboplatin, cisplatin, etoposide, 5fluorouracil, oxaliplatin, capecitabine CYLD BCL2 2
onc-392, pembrolizumab, docetaxel CYLD BCL2 2
paclitaxel CYLD BCL2 2
pembrolizumab, paclitaxel CYLD BCL2 2
pembrolizumab, paclitaxel, docetaxel, irinotecan CYLD BCL2 2
pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin CYLD BCL2 2
pralatrexate, docetaxel, fludeoxyglucose f 18, positron emission tomography CYLD BCL2 2
ramucirumab, paclitaxel CYLD BCL2 2
5-fluorouracil (5-fu), leucovorin, oxaliplatin, atezolizumab, cobimetinib, ramucirumab, paclitaxel, pegylated recombinant human hyaluronidase (pegph20), bl-8040, linagliptin, atezolizumab, cobimetinib, cisplatin, tiragolumab, 5-fluorouracil (5-fu) CYLD BCL2 1
5-fluorouracil, docetaxel, oxaliplatin CYLD BCL2 1
5-fluorouracil, leucovorin, oxaliplatin, docetaxel, carboplatin, paclitaxel, neoadjuvant radiation CYLD BCL2 1
5-fluoruracil, cisplatinum, docetaxel CYLD BCL2 1
5-fu, leucovorin, docetaxel, oxaliplatin (flot), trastuzumab, post-operative treatment trastuzumab mono therapy CYLD BCL2 1
afatinib, dasatinib, palbociclib, everolimus, olaparib CYLD CSK 1
afatinib, docetaxel, radiation therapy CYLD BCL2 1
afuresertib, nab paclitaxel, docetaxel, sintilimab CYLD BCL2 1
agent-797, botensilimab, balstilimab, ramucirumab, paclitaxel CYLD BCL2 1
ak109, paclitaxel, paclitaxel, ak104 CYLD BCL2 1
aldesleukin, autologous tumor cell vaccine, filgrastim, sargramostim, therapeutic autologous lymphocytes, carmustine, cisplatin, cyclophosphamide, paclitaxel, autologous bone marrow transplantation, conventional surgery, peripheral blood stem cell transplantation CYLD BCL2 1
alvocidib, docetaxel CYLD BCL2 1
andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel CYLD BCL2 1
anetumab ravtansine, bevacizumab, paclitaxel CYLD BCL2 1
ascorbic acid, paclitaxel protein-bound, cisplatin, gemcitabine CYLD EGLN1 1
atezolizumab, 5-fluorouracil, calciumfolinat, oxaliplatin, docetaxel CYLD BCL2 1
atezolizumab, biospecimen collection, capecitabine, computed tomography, docetaxel, echocardiography, fluorouracil, leucovorin calcium, lymphadenectomy, magnetic resonance imaging, oxaliplatin, positron emission tomography, surgical procedure CYLD BCL2 1
atezolizumab, tiragolumab, paclitaxel, cisplatin, atezolizumab matching placebo, tiragolumab matching placebo CYLD BCL2 1
avelumab, irinotecan, paclitaxel, best supportive care (bsc) CYLD BCL2 1
azd6244, dacarbazine, erlotinib, docetaxel, temsirolimus CYLD BCL2 1
bbi608, paclitaxel, placebo CYLD BCL2 1
bemarituzumab, paclitaxel, ramucirumab, bemarituzumab, irinotecan, bemarituzumab, trifluridine/tipiracil CYLD BCL2 1
bethanechol CYLD CHRM4 1
bethanechol, gemcitabine, nab-paclitaxel CYLD CHRM4 1
bevacizumab, dasatinib, placebo CYLD CSK 1
bevacizumab, docetaxel, oxaliplatin CYLD BCL2 1
biological ni-1801, ni-1801 in combination with anti-pd1 (pembrolizumab), ni-1801 in combination with paclitaxel, paclitaxel CYLD BCL2 1
biopsy, biospecimen collection, computed tomography, copanlisib, magnetic resonance imaging CYLD PIK3CB 1
biopsy, biospecimen collection, copanlisib, radiologic examination CYLD PIK3CB 1
biospecimen collection, cholestyramine, computed tomography, diagnostic imaging, gemcitabine, leflunomide, magnetic resonance imaging CYLD DHODH 1
biospecimen collection, computed tomography, endoscopic ultrasound, esophagogastroduodenoscopy, fluorouracil, hypofractionated radiation therapy, leucovorin calcium, oxaliplatin, positron emission tomography, survey administration, docetaxel CYLD BCL2 1
biospecimen collection, computed tomography, magnetic resonance imaging, nivolumab, paclitaxel, questionnaire administration, ramucirumab CYLD BCL2 1
biospecimen collection, electronic health record review, fentanyl citrate, propofol, questionnaire administration, sevoflurane, surgical procedure CYLD SCN4A 1
biospecimen collection, lidocaine, resection CYLD SCN4A 1
bl-b01d1, irinotecan, paclitaxel, docetaxel CYLD BCL2 1
bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan CYLD BCL2 1
bortezomib, carboplatin, paclitaxel CYLD BCL2 1
cadonilimab, ak117, oxaliplatin, tegafur-gimeracil-oteracil potassium, docetaxel, 5-fluorouracil CYLD BCL2 1
cadonilimab, pulocimab, paclitaxel, placebo CYLD BCL2 1
cadonilimab, radiotherapy, carboplatin, paclitaxel CYLD BCL2 1
camrelizumab, docetaxel, irinotecan CYLD BCL2 1
camrelizumab, irinotecan, paclitaxel, paclitaxel-albumin, docetaxel, anlotinib CYLD BCL2 1
camrelizumab, paclitaxel, cisplatin CYLD BCL2 1
camrelizumab, paclitaxel, cisplatin, radiotherapy CYLD BCL2 1
capecitabine, carboplatin, docetaxel, fluorouracil, hafnium oxide-containing nanoparticles nbtxr3, intensity-modulated radiation therapy, leucovorin, oxaliplatin, paclitaxel CYLD BCL2 1
capecitabine, cisplatin, docetaxel, epirubicin hydrochloride, gemcitabine hydrochloride CYLD BCL2 1
capecitabine, docetaxel, fluorouracil, leucovorin, oxaliplatin, radiation therapy, surgical procedure CYLD BCL2 1
capecitabine, docetaxel, fluorouracil, oxaliplatin, radiation therapy, therapeutic conventional surgery CYLD BCL2 1
carboplatin, 3 dimensional conformal radiation therapy, propranolol, intensity modulated radiation therapy, paclitaxel CYLD BCL2 1
carboplatin, cisplatin, docetaxel, etoposide, pembrolizumab CYLD BCL2 1
carboplatin, computed tomography, fluorouracil, laboratory biomarker analysis, leucovorin calcium, oxaliplatin, paclitaxel, pembrolizumab, positron emission tomography, radiation therapy, therapeutic conventional surgery CYLD BCL2 1
carboplatin, ganetespib, paclitaxel, radiation therapy CYLD BCL2 1
carboplatin, laboratory biomarker analysis, paclitaxel, quality-of-life assessment, radiation therapy, therapeutic conventional surgery, trastuzumab CYLD BCL2 1
carboplatin, laboratory biomarker analysis, paclitaxel, wild-type reovirus CYLD BCL2 1
carboplatin, paclitaxel, azd1775 CYLD BCL2 1
carboplatin, paclitaxel, vadimezan CYLD BCL2 1
carboxyamidotriazole, paclitaxel CYLD BCL2 1
catumaxomab, fluorouracil, leucovorin, oxaliplatin, docetaxel, fluorouracil, leucovorin, oxaliplatin, docetaxel CYLD BCL2 1
cetuximab (erbitux), paclitaxel, cisplatin, radiation CYLD BCL2 1
cetuximab, cisplatin, paclitaxel, radiation therapy CYLD BCL2 1
cisplatin, docetaxel, floxuridine, fluorouracil, leucovorin calcium, conventional surgery CYLD BCL2 1
cisplatin, docetaxel, fluorouracil, radiation therapy CYLD BCL2 1
cisplatin, docetaxel, gemcitabine hydrochloride CYLD BCL2 1
cisplatin, docetaxel, gemcitabine hydrochloride, irinotecan hydrochloride CYLD BCL2 1
cisplatin, irinotecan hydrochloride, paclitaxel, conventional surgery, radiation therapy CYLD BCL2 1
cisplatin, oxaliplatin, fluorouracil (5-fu), capecitabine, paclitaxel, tislelizumab, placebo CYLD BCL2 1
cisplatin, paclitaxel, 5-fu CYLD BCL2 1
cisplatin, paclitaxel, adjuvant therapy, radiation therapy CYLD BCL2 1
cisplatin, paclitaxel, brachytherapy, radiation therapy CYLD BCL2 1
cisplatin, paclitaxel, surgical procedure CYLD BCL2 1
cisplatin, paclitaxel, topotecan hydrochloride CYLD BCL2 1
crenolanib, ramucirumab, paclitaxel CYLD BCL2 1
dalteparin, gemcitabine hydrochloride, diagnostic laboratory biomarker analysis CYLD SERPINC1 1
dalteparin, gemcitabine hydrochloride, diagnostic laboratory biomarker analysis CYLD SELP 1
dalteparin, radiation therapy CYLD SERPINC1 1
dalteparin, radiation therapy CYLD SELP 1
dasatinib, erlotinib hydrochloride, gemcitabine hydrochloride CYLD CSK 1
dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis, mutation analysis, nucleic acid sequencing, immunohistochemistry staining method CYLD CSK 1
dasatinib, laboratory biomarker analysis, physiologic testing CYLD CSK 1
dasatinib, mfolfox6 CYLD CSK 1
dasatinib, pharmacological study CYLD CSK 1
dasatinib, temozolomide, placebo, radiation therapy CYLD CSK 1
dexamethasone, diphenhydramine, famotidine, mitomycin c, cisplatin, paclitaxel CYLD BCL2 1
dexamethasone, diphenhydramine, famotidine, mitomycin c, cisplatin, paclitaxel CYLD HRH2 1
disulfiram, copper, alkylating agents CYLD SERPINC1 1
docetaxel CYLD BCL2 1
docetaxel for injection (albumin-bound), sg001, cisplatin for injection, paclitaxel, simultaneous radiotherapy CYLD BCL2 1
docetaxel, 5-fluorouracil, oxaliplatin, folinic acid CYLD BCL2 1
docetaxel, cisplatin and 5-fluorouracil CYLD BCL2 1
docetaxel, cisplatin, capecitabine, radiation, capecitabine CYLD BCL2 1
docetaxel, cisplatin, fluorouracil, bevacizumab, leucovorin CYLD BCL2 1
docetaxel, cisplatin, radiation, surgery, vinorelbine, cisplatin CYLD BCL2 1
docetaxel, cisplatin, radiotherapy CYLD BCL2 1
docetaxel, fgfr inhibitor azd4547, laboratory biomarker analysis CYLD BCL2 1
docetaxel, floxuridine, leucovorin, oxaliplatin, microarray analysis, reverse transcriptase-polymerase chain reaction, conventional surgery CYLD BCL2 1
docetaxel, fluorouracil, oxaliplatin, pembrolizumab, radiation therapy CYLD BCL2 1
docetaxel, gemcitabine CYLD BCL2 1
docetaxel, gemcitabine hydrochloride CYLD BCL2 1
docetaxel, hyperfractionation, intensity-modulated radiation therapy, laboratory biomarker analysis, quality-of-life assessment CYLD BCL2 1
docetaxel, irinotecan hydrochloride CYLD BCL2 1
docetaxel, laboratory biomarker analysis, palbociclib CYLD BCL2 1
docetaxel, leucovorin, fluorouracil, cisplatin, docetaxel, cisplatin, fluorouracil, neulasta, or neupogen, docetaxel, leukvorin, flurouracil, cisplatin, trastuzumab CYLD BCL2 1
docetaxel, nedaplatin, chest radiation CYLD BCL2 1
docetaxel, oxaliplatin, capecitabine, trastuzumab CYLD BCL2 1
docetaxel, oxaliplatin, leucovorin, fluorouracil CYLD BCL2 1
docetaxel, oxaliplatin, radiotherapy CYLD BCL2 1
docetaxel, oxaliplatin, s-1 and durvalumab, durvalumab and tremelimumab CYLD BCL2 1
docetaxel, rna analysis, reverse transcriptase-polymerase chain reaction, circulating tumor cell analysis, laboratory biomarker analysis CYLD BCL2 1
docetaxel, steroid therapy, questionnaire administration, nausea and vomiting therapy, pain therapy, quality-of-life assessment, standard follow-up care, radiation therapy CYLD BCL2 1
durvalumab, carboplatin, paclitaxel, radiotherapy 23 x 1.8 gy CYLD BCL2 1
endoscopic variceal ligation, carvedilol CYLD ADRA2B 1
epacadostat, pembrolizumab, oxaliplatin, leucovorin, 5-fluorouracil, gemcitabine, nab-paclitaxel, carboplatin, paclitaxel, pemetrexed, cyclophosphamide, carboplatin, cisplatin, 5-fluorouracil, investigator's choice of platinum agent CYLD BCL2 1
epirubicin, cisplatin / oxaliplatin, 5 flourouracil/ capecitabine, (41.4 gy/23 fractions), paclitaxel, carboplatin, docetaxel, oxaliplatin, leucovorin, 5-fluorouracil CYLD BCL2 1
eras-007, encorafenib, cetuximab, palbociclib CYLD MAPK9 1
eras-007, encorafenib, cetuximab, palbociclib CYLD STK36 1
ethanol, enoxaparin CYLD SERPINC1 1
ethanol, enoxaparin CYLD CACNG1 1
ethanol, enoxaparin CYLD CHRNA9 1
etomidate, midazolam, meperidine CYLD ADRA2B 1
evorpacept (alx148), trastuzumab, ramucirumab, paclitaxel CYLD BCL2 1
external beam radiotherapy, bintrafusp alfa, paclitaxel, carboplatin CYLD BCL2 1
farletuzumab, placebo, carboplatin, paclitaxel, pemetrexed, cisplatin CYLD BCL2 1
filgrastim, amifostine trihydrate, cisplatin, etoposide, paclitaxel, topotecan hydrochloride, radiation therapy CYLD BCL2 1
filgrastim, carboplatin, cyclophosphamide, paclitaxel, topotecan hydrochloride, peripheral blood stem cell transplantation CYLD BCL2 1
filgrastim, carboplatin, etoposide, paclitaxel, topotecan hydrochloride, radiation therapy CYLD BCL2 1
filgrastim, carboplatin, paclitaxel, topotecan hydrochloride CYLD BCL2 1
filgrastim, docetaxel, gemcitabine hydrochloride CYLD BCL2 1
folfox regimen, docetaxel, fluorouracil, irinotecan hydrochloride, leucovorin calcium, oxaliplatin CYLD BCL2 1
folfox/ nal-iri, paclitaxel, carboplatin, proton radiation therapy CYLD BCL2 1
fosifloxuridine nafalbenamide, leucovorin, pembrolizumab, docetaxel CYLD BCL2 1
gb201, paclitaxel, gemcitabine, standard of care treatment options CYLD BCL2 1
gemcitabine hydrochloride, docetaxel, capecitabine, intensity-modulated radiation therapy, oxaliplatin, pancreatic surgical procedure, therapeutic conventional surgery, laboratory biomarker analysis CYLD BCL2 1
gemcitabine, docetaxel, radiation CYLD BCL2 1
gemcitabine, paclitaxel CYLD BCL2 1
gen1042, pembrolizumab, cisplatin, carboplatin, 5-fu, gemcitabine, nab paclitaxel, pemetrexed, paclitaxel CYLD BCL2 1
hmbd-001, docetaxel, cetuximab CYLD BCL2 1
hmbd-001, docetaxel, nab-paclitaxel, gemcitabine CYLD BCL2 1
ibrutinib, paclitaxel, gemcitabine CYLD BCL2 1
ifinatamab deruxtecan, docetaxel, paclitaxel, irinotecan CYLD BCL2 1
interferon alpha, 13-cis-retinoic acid, paclitaxel CYLD BCL2 1
involved field irradiation, elective field irradiation, paclitaxel, platinum, peg-rhg-csf CYLD BCL2 1
irinotecan hydrochloride, paclitaxel CYLD BCL2 1
irinotecan, ibi343, paclitaxel CYLD BCL2 1
irinotecan, leucovorin, 5-fluorouracil, docetaxel, cisplatin, leucovorin, 5-fluorouracil CYLD BCL2 1
kc1036, irinotecan, docetaxel, s-1 CYLD BCL2 1
ketoconazole CYLD CYP17A1 1
kk2269, docetaxel CYLD BCL2 1
leflunomide, procarbazine hydrochloride CYLD DHODH 1
licochalcone a, paclitaxel CYLD BCL2 1
liposomal irinotecan, fluorouracil, folinic acid, docetaxel CYLD BCL2 1
ljm716, byl719, paclitaxel, docetaxel, irinotecan CYLD BCL2 1
medical cannabis CYLD CYP17A1 1
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable candidates from cansar.ai — these are potential drug-cancer reuse candidates, not evidence of efficacy.