Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade (PubMed:15140129, PubMed:15853774). AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa (PubMed:15140129). Its inhibitory activity is greatly enhanced in the presence of heparin
Forms protease inhibiting heterodimer with TMPRSS7
Found in plasma
An important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. Antithrombin-III deficiency is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels.
Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III.
Type IV: consists of miscellaneous group of unclassifiable mutations.
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Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to SERPINC1, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 1
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT04582188 | Sepsis, Coagulopathy, Outcome, Fatal | The Early Coagulopathy for the Prognosis in Sepsis | N/A | UNKNOWN |
| NCT00938288 | Congenital Antithrombin Deficiency | A Study of KW-3357 in Congenital Antithrombin Deficiency | PHASE1 | COMPLETED |
| NCT07549568 | Heparin Resistance, Cardiac Surgery, Cardiopulmonary Bypass | Antithrombin as a Predictor of Heparin Resistance in Cardiac Surgery With Cardiopulmonary Bypass | N/A | NOT_YET_RECRUITING |
| NCT04651400 | Covid19 | Observational, Retrospective Study to Evaluate Coagulation Changes and the Influence of Antithrombin III Treatment in Patients With Severe COVID-19 Infection | N/A | COMPLETED |
| NCT05891899 | Antithrombin III Deficiency | Belgian Antithrombin Deficiency Registry | N/A | NOT_YET_RECRUITING |
| NCT00925639 | Menopause | Effects of the Concentrated Extract of Soy on Coagulation Factors After Menopause | PHASE3 | UNKNOWN |
| NCT04879550 | Antithrombin III Deficiency, Extracorporeal Membrane Oxygenation Complication | Prospective Investigation of Antithrombin III Deficiency in Adult Patients With ECMO | N/A | COMPLETED |
| NCT00319228 | Antithrombin III Deficiency | Safety, Pharmacokinetics and Efficacy of an ATIII Concentrate | PHASE2, PHASE3 | ACTIVE_NOT_RECRUITING |
| NCT07036809 | Acute Leukemia | Assessment of Antithrombin III, Protein C, Protein S and D-dimer in Acute Leukemia | N/A | COMPLETED |
| NCT04745442 | Covid19, Severe Acute Respiratory Syndrome, Distress Respiratory Syndrome | Pilot Study of Antithrombin as Prophylaxis of Acute Respiratory Distress Syndrome in Patients With COVID-19 | PHASE2 | COMPLETED |