Drugs that target a gene either directly (oncogene) or via a synthetic-lethal partner (SLP) of a mutated tumour suppressor (TSG). Cell colour shows the strongest known status of that drug for that cancer subtype: approved clinical trial repositionable (potential reuse, no evidence yet) or blank.
| Drug | TSG | SLP (drug target) | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | # |
|---|---|---|---|---|---|---|---|---|---|---|
| olaparib | CHEK1 | PARP1 | 1 | |||||||
| sunitinib | CHEK1 | MET | 5 | |||||||
| crizotinib | CHEK1 | MET | 6 | |||||||
| gemcitabine | CHEK1 | RRM1 | 6 | |||||||
| bevacizumab | CHEK1 | VEGFA | 3 | |||||||
| gemcitabine | CHEK1 | TYMS | 3 | |||||||
| gemcitabine | CHEK1 | CMPK1 | 3 | |||||||
| lurbinectedin, irinotecan | CHEK1 | TOP1 | 3 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | CHEK1 | VEGFA | 3 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | CHEK1 | FGFR2 | 3 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | CHEK1 | ABL1 | 3 | |||||||
| regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) | CHEK1 | FGFR2 | 3 | |||||||
| regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) | CHEK1 | ABL1 | 3 | |||||||
| srf617, gemcitabine, albumin-bound paclitaxel, pembrolizumab | CHEK1 | TYMS | 3 | |||||||
| srf617, gemcitabine, albumin-bound paclitaxel, pembrolizumab | CHEK1 | RRM1 | 3 | |||||||
| srf617, gemcitabine, albumin-bound paclitaxel, pembrolizumab | CHEK1 | CMPK1 | 3 | |||||||
| cabozantinib | CHEK1 | MET | 6 | |||||||
| capecitabine | CHEK1 | TYMS | 6 | |||||||
| everolimus | CHEK1 | MTOR | 6 | |||||||
| ibrutinib | CHEK1 | BTK | 6 | |||||||
| nintedanib | CHEK1 | FGFR2 | 6 | |||||||
| regorafenib | CHEK1 | FGFR2 | 6 | |||||||
| regorafenib | CHEK1 | ABL1 | 6 | |||||||
| sacituzumab govitecan | CHEK1 | TOP1 | 6 | |||||||
| topotecan | CHEK1 | TOP1 | 6 | |||||||
| 5fu, nab-paclitaxel, bevacizumab, calcium leucovorin, oxaliplatin | CHEK1 | VEGFA | 2 | |||||||
| ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine | CHEK1 | VEGFA | 2 | |||||||
| ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine | CHEK1 | TYMS | 2 | |||||||
| ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine | CHEK1 | RRM1 | 2 | |||||||
| ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine | CHEK1 | CMPK1 | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | CHEK1 | SMO | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | CHEK1 | PIK3CA | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | CHEK1 | MAP2K1 | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | CHEK1 | SRC | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | CHEK1 | MET | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | CHEK1 | WEE1 | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | CHEK1 | FGFR2 | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | CHEK1 | MAPK1 | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | CHEK1 | AKT1 | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | CHEK1 | BTK | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | CHEK1 | ABL1 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | CHEK1 | IGF1R | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | CHEK1 | TYMS | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | CHEK1 | MAP2K1 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | CHEK1 | MET | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | CHEK1 | DHFR | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | CHEK1 | FGFR2 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | CHEK1 | ABL1 | 2 | |||||||
| apatinib, irinotecan | CHEK1 | TOP1 | 2 | |||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | CHEK1 | TYMS | 2 | |||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | CHEK1 | TOP1 | 2 | |||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | CHEK1 | RRM1 | 2 | |||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | CHEK1 | CMPK1 | 2 | |||||||
| avelumab, lorlatanib, talazoparib, pemetrexed, axitinib, cmp 001, utomilumab, pf04518600 | CHEK1 | TYMS | 2 | |||||||
| avelumab, lorlatanib, talazoparib, pemetrexed, axitinib, cmp 001, utomilumab, pf04518600 | CHEK1 | DHFR | 2 | |||||||
| binimetinib, biopsy, biospecimen collection, bone scan, computed tomography, magnetic resonance imaging, palbociclib | CHEK1 | MAP2K1 | 2 | |||||||
| capecitabine, cisplatin | CHEK1 | TYMS | 2 | |||||||
| capecitabine, temozolomide | CHEK1 | TYMS | 2 | |||||||
| cft1946, trametinib, cetuximab | CHEK1 | MAP2K1 | 2 | |||||||
| cisplatin, pemetrexed, gemcitabine, carboplatin, certolizumab, nivolumab | CHEK1 | TYMS | 2 | |||||||
| cisplatin, pemetrexed, gemcitabine, carboplatin, certolizumab, nivolumab | CHEK1 | DHFR | 2 | |||||||
| cisplatin, pemetrexed, gemcitabine, carboplatin, certolizumab, nivolumab | CHEK1 | RRM1 | 2 | |||||||
| cisplatin, pemetrexed, gemcitabine, carboplatin, certolizumab, nivolumab | CHEK1 | CMPK1 | 2 | |||||||
| cixutumumab, everolimus, laboratory biomarker analysis, octreotide acetate, pharmacological study | CHEK1 | IGF1R | 2 | |||||||
| cixutumumab, everolimus, laboratory biomarker analysis, octreotide acetate, pharmacological study | CHEK1 | MTOR | 2 | |||||||
| cobimetinib, mehd7945a | CHEK1 | MAP2K1 | 2 | |||||||
| dec-205/ny-eso-1 fusion protein cdx-1401, laboratory biomarker analysis, pharmacological study, sirolimus | CHEK1 | MTOR | 2 | |||||||
| entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib | CHEK1 | FGFR2 | 2 | |||||||
| futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan | CHEK1 | TOP1 | 2 | |||||||
| futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan | CHEK1 | FGFR2 | 2 | |||||||
| inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide | CHEK1 | TYMS | 2 | |||||||
| inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide | CHEK1 | DHFR | 2 | |||||||
| inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide | CHEK1 | TOP1 | 2 | |||||||
| ioa-244, avelumab injection, pemetrexed, cisplatin, ruxolitinib | CHEK1 | TYMS | 2 | |||||||
| ioa-244, avelumab injection, pemetrexed, cisplatin, ruxolitinib | CHEK1 | DHFR | 2 | |||||||
| jab-3312, binimetinib, pembrolizumab, sotorasib, osimertinib | CHEK1 | MAP2K1 | 2 | |||||||
| ksq-001ex, interleukin-2, cyclophosphamide, fludarabine | CHEK1 | DCK | 2 | |||||||
| ksq-001ex, interleukin-2, cyclophosphamide, fludarabine | CHEK1 | RRM1 | 2 | |||||||
| lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate | CHEK1 | FGFR2 | 2 | |||||||
| melphalan, bcnu, vitamin b12b, vitamin c, ethanol, autologous hematopoietic stem cells | CHEK1 | SLC29A2 | 2 | |||||||
| melphalan, bcnu, vitamin b12b, vitamin c, ethanol, autologous hematopoietic stem cells | CHEK1 | SLC29A1 | 2 | |||||||
| mirdametinib, bgb-3245 | CHEK1 | MAP2K1 | 2 | |||||||
| mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed | CHEK1 | TYMS | 2 | |||||||
| mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed | CHEK1 | DHFR | 2 | |||||||
| mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed | CHEK1 | RRM1 | 2 | |||||||
| mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed | CHEK1 | CMPK1 | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | CHEK1 | TYMS | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | CHEK1 | DHFR | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | CHEK1 | FGFR2 | 2 | |||||||
| motexafin gadolinium, radiation therapy | CHEK1 | RRM2 | 2 | |||||||
| nab-paclitaxel, gemcitabine | CHEK1 | TYMS | 2 | |||||||
| nab-paclitaxel, gemcitabine | CHEK1 | RRM1 | 2 | |||||||
| nab-paclitaxel, gemcitabine | CHEK1 | CMPK1 | 2 | |||||||
| nintedanib | CHEK1 | SRC | 2 | |||||||
| nintedanib, pembrolizumab | CHEK1 | SRC | 2 | |||||||
| nintedanib, pembrolizumab | CHEK1 | FGFR2 | 2 | |||||||
| nivolumab, ipilimumab, cobimetinib | CHEK1 | MAP2K1 | 2 | |||||||
| oleclumab, durvalumab, gemcitabine, nab-paclitaxel, oxaliplatin, folinic acid, 5-fu | CHEK1 | TYMS | 2 | |||||||
| oleclumab, durvalumab, gemcitabine, nab-paclitaxel, oxaliplatin, folinic acid, 5-fu | CHEK1 | RRM1 | 2 | |||||||
| oleclumab, durvalumab, gemcitabine, nab-paclitaxel, oxaliplatin, folinic acid, 5-fu | CHEK1 | CMPK1 | 2 | |||||||
| osimertinib, bevacizumab, osimertinib | CHEK1 | VEGFA | 2 | |||||||
| pd-1 inhibitor, bevacizumab, carboplatin, cisplatin, pemtrexed | CHEK1 | VEGFA | 2 | |||||||
| pembrolizumab, belzutifan, lenvatinib | CHEK1 | FGFR2 | 2 | |||||||
| pembrolizumab, lenvatinib | CHEK1 | FGFR2 | 2 | |||||||
| pemetrexed, bevacizumab | CHEK1 | VEGFA | 2 | |||||||
| pemetrexed, bevacizumab | CHEK1 | TYMS | 2 | |||||||
| pemetrexed, bevacizumab | CHEK1 | DHFR | 2 | |||||||
| pentostatin, cyclophosphamide, ss1(dsfv)pe38 - lot 073i0809, ss1(dsfv)pe38 - lot fil129j01 | CHEK1 | ADA | 2 | |||||||
| pharmacological study, romidepsin | CHEK1 | HDAC6 | 2 | |||||||
| regorafenib, laboratory biomarker analysis | CHEK1 | FGFR2 | 2 | |||||||
| regorafenib, laboratory biomarker analysis | CHEK1 | ABL1 | 2 | |||||||
| rubitecan | CHEK1 | TOP1 | 2 | |||||||
| selumetinib, medi4736, tremelimumab | CHEK1 | MAP2K1 | 2 | |||||||
| sy-5609, fulvestrant, gemcitabine, nab-paclitaxel | CHEK1 | TYMS | 2 | |||||||
| sy-5609, fulvestrant, gemcitabine, nab-paclitaxel | CHEK1 | RRM1 | 2 | |||||||
| sy-5609, fulvestrant, gemcitabine, nab-paclitaxel | CHEK1 | CMPK1 | 2 | |||||||
| temsirolimus | CHEK1 | MTOR | 2 | |||||||
| temsirolimus, laboratory biomarker analysis | CHEK1 | MTOR | 2 | |||||||
| tislelizumab, pemetrexed | CHEK1 | TYMS | 2 | |||||||
| tislelizumab, pemetrexed | CHEK1 | DHFR | 2 | |||||||
| tivantinib | CHEK1 | MET | 2 | |||||||
| whole brain low dose radiotherapy, pemetrexed, sintilimab, chemotherapy | CHEK1 | TYMS | 2 | |||||||
| whole brain low dose radiotherapy, pemetrexed, sintilimab, chemotherapy | CHEK1 | DHFR | 2 | |||||||
| binimetinib | CHEK1 | MAP2K1 | 6 | |||||||
| bosutinib | CHEK1 | SRC | 6 | |||||||
| bosutinib | CHEK1 | ABL1 | 6 | |||||||
| mycophenolic acid | CHEK1 | IMPDH1 | 6 | |||||||
| pemetrexed | CHEK1 | TYMS | 6 | |||||||
| pemetrexed | CHEK1 | DHFR | 6 | |||||||
| pemigatinib | CHEK1 | FGFR2 | 6 | |||||||
| ponatinib | CHEK1 | ABL1 | 6 | |||||||
| romidepsin | CHEK1 | HDAC6 | 6 | |||||||
| selumetinib | CHEK1 | MAP2K1 | 6 | |||||||
| trastuzumab deruxtecan | CHEK1 | TOP1 | 4 | |||||||
| 3-dimensional conformal radiation therapy, bevacizumab, cisplatin, fluorouracil, intensity-modulated radiation therapy | CHEK1 | VEGFA | 1 | |||||||
| 3-dimensional conformal radiation therapy, bevacizumab, cisplatin, fluorouracil, intensity-modulated radiation therapy | CHEK1 | TYMS | 1 | |||||||
| 3-dimensional conformal radiation therapy, bevacizumab, intensity-modulated radiation therapy, laboratory biomarker analysis, placebo, quality-of-life assessment, temozolomide | CHEK1 | VEGFA | 1 | |||||||
| 3-dimensional conformal radiation therapy, biospecimen collection, capecitabine, chemotherapy, computed tomography, erlotinib hydrochloride, fluorouracil, gemcitabine hydrochloride, intensity-modulated radiation therapy, magnetic resonance imaging, quality-of-life assessment, x-ray imaging | CHEK1 | TYMS | 1 | |||||||
| 3-dimensional conformal radiation therapy, cognitive assessment, laboratory biomarker analysis, temozolomide, vorinostat | CHEK1 | HDAC6 | 1 | |||||||
| 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, vorinostat | CHEK1 | HDAC6 | 1 | |||||||
| 3-dimensional conformal radiation therapy, motexafin gadolinium, temozolomide | CHEK1 | RRM2 | 1 | |||||||
| 4-dimensional computed tomography, fluorouracil, gemcitabine hydrochloride, laboratory biomarker analysis, leucovorin calcium, nelfinavir mesylate, oregovomab, stereotactic body radiation therapy, therapeutic conventional surgery | CHEK1 | TYMS | 1 | |||||||
| 5 fluorouracil, leucovorin, irinotecan, oxaliplatin | CHEK1 | TOP1 | 1 | |||||||
| 5-fu, atezolizumab, bevacizumab, gemcitabine, leucovorin, nab-paclitaxel, oxaliplatin, capecitabine, cisplatin | CHEK1 | VEGFA | 1 | |||||||
| 5-fu, atezolizumab, bevacizumab, gemcitabine, leucovorin, nab-paclitaxel, oxaliplatin, capecitabine, cisplatin | CHEK1 | TYMS | 1 | |||||||
| 5-fu, atezolizumab, bevacizumab, gemcitabine, leucovorin, nab-paclitaxel, oxaliplatin, capecitabine, cisplatin | CHEK1 | RRM1 | 1 | |||||||
| 5-fu, atezolizumab, bevacizumab, gemcitabine, leucovorin, nab-paclitaxel, oxaliplatin, capecitabine, cisplatin | CHEK1 | CMPK1 | 1 | |||||||
| 6,8-bis(benzylthio)octanoic acid, oxaliplatin, leucovorin calcium, irinotecan hydrochloride, fluorouracil, laboratory biomarker analysis | CHEK1 | TYMS | 1 | |||||||
| 7-hydroxystaurosporine, fluorouracil | CHEK1 | TYMS | 1 | |||||||
| 9-ing-41, gemcitabine - 21 day cycle, doxorubicin., lomustine, carboplatin., nab paclitaxel., paclitaxel., gemcitabine - 28 day cycle, irinotecan | CHEK1 | TOP1 | 1 | |||||||
| 9-ing-41, retifanlimab, gemcitabine, abraxane | CHEK1 | TYMS | 1 | |||||||
| 9-ing-41, retifanlimab, gemcitabine, abraxane | CHEK1 | RRM1 | 1 | |||||||
| 9-ing-41, retifanlimab, gemcitabine, abraxane | CHEK1 | CMPK1 | 1 | |||||||
| ab598, zimberelimab, fluorouracil, leucovorin, oxaliplatin | CHEK1 | TYMS | 1 | |||||||
| abemaciclib, bevacizumab | CHEK1 | VEGFA | 1 | |||||||
| abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf | CHEK1 | TOP1 | 1 | |||||||
| abemaciclib, ly3023414, gemcitabine, capecitabine | CHEK1 | TYMS | 1 | |||||||
| abemaciclib, ly3023414, gemcitabine, capecitabine | CHEK1 | RRM1 | 1 | |||||||
| abemaciclib, ly3023414, gemcitabine, capecitabine | CHEK1 | CMPK1 | 1 | |||||||
| abraxane (nab-paclitaxel), gemcitabine | CHEK1 | TYMS | 1 | |||||||
| abraxane (nab-paclitaxel), gemcitabine | CHEK1 | RRM1 | 1 | |||||||
| abraxane (nab-paclitaxel), gemcitabine | CHEK1 | CMPK1 | 1 | |||||||
| adavosertib | CHEK1 | WEE1 | 1 | |||||||
| adavosertib, laboratory biomarker analysis, pharmacological study, radiation therapy | CHEK1 | WEE1 | 1 | |||||||
| adavosertib, radiation therapy | CHEK1 | WEE1 | 1 | |||||||
| adavosertib, radiation therapy, temozolomide | CHEK1 | WEE1 | 1 | |||||||
| adct-601, gemcitabine | CHEK1 | TYMS | 1 | |||||||
| adct-601, gemcitabine | CHEK1 | RRM1 | 1 | |||||||
| adct-601, gemcitabine | CHEK1 | CMPK1 | 1 | |||||||
| adebrelimab injection, apatinib mesylate tablets, carboplatin, cisplatin, etoposide | CHEK1 | TOP2A | 1 | |||||||
| adebrelimab, apatinib mesylate, etoposide, carboplatin | CHEK1 | TOP2A | 1 | |||||||
| adebrelimab, apatinib, tegafur | CHEK1 | TYMS | 1 | |||||||
| adebrelimab, carboplatin/cisplatin, etoposide, radiation therapy | CHEK1 | TOP2A | 1 | |||||||
| adebrelimab, radiation therapy, etoposide, carboplatin(ec) | CHEK1 | TOP2A | 1 | |||||||
| aee788, everolimus | CHEK1 | MTOR | 1 | |||||||
| afatinib dimaleate, capecitabine, laboratory biomarker analysis | CHEK1 | TYMS | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | CHEK1 | MTOR | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | CHEK1 | SRC | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | CHEK1 | BTK | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | CHEK1 | ABL1 | 1 | |||||||
| afatinib, irinotecan | CHEK1 | TOP1 | 1 | |||||||
| ag-013736, gemcitabine, gemcitabine, placebo | CHEK1 | TYMS | 1 | |||||||
| ag-013736, gemcitabine, gemcitabine, placebo | CHEK1 | RRM1 | 1 | |||||||
| ag-013736, gemcitabine, gemcitabine, placebo | CHEK1 | CMPK1 | 1 | |||||||
| agen1423, botensilimab, gemcitabine, nab-paclitaxel | CHEK1 | TYMS | 1 | |||||||
| agen1423, botensilimab, gemcitabine, nab-paclitaxel | CHEK1 | RRM1 | 1 | |||||||
| agen1423, botensilimab, gemcitabine, nab-paclitaxel | CHEK1 | CMPK1 | 1 | |||||||
| ags-1c4d4, gemcitabine | CHEK1 | TYMS | 1 | |||||||
| ags-1c4d4, gemcitabine | CHEK1 | RRM1 | 1 | |||||||
| ags-1c4d4, gemcitabine | CHEK1 | CMPK1 | 1 | |||||||
| ak104, ak104, gemcitabine, nab-paclitaxel | CHEK1 | TYMS | 1 | |||||||
| ak104, ak104, gemcitabine, nab-paclitaxel | CHEK1 | RRM1 | 1 | |||||||
| ak104, ak104, gemcitabine, nab-paclitaxel | CHEK1 | CMPK1 | 1 | |||||||
| ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, nab-paclitaxel, gemcitabine, nab-paclitaxel, gemcitabine | CHEK1 | TYMS | 1 | |||||||
| ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, nab-paclitaxel, gemcitabine, nab-paclitaxel, gemcitabine | CHEK1 | RRM1 | 1 | |||||||
| ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, nab-paclitaxel, gemcitabine, nab-paclitaxel, gemcitabine | CHEK1 | CMPK1 | 1 | |||||||
| akt inhibitor mk2206, fluorouracil, oxaliplatin, selumetinib | CHEK1 | TYMS | 1 | |||||||
| akt inhibitor mk2206, fluorouracil, oxaliplatin, selumetinib | CHEK1 | MAP2K1 | 1 | |||||||
| albumin-bound paclitaxel (abi-007), gemcitabine | CHEK1 | TYMS | 1 | |||||||
| albumin-bound paclitaxel (abi-007), gemcitabine | CHEK1 | RRM1 | 1 |