Drug × Cancer matrix

Drugs that target a gene either directly (oncogene) or via a synthetic-lethal partner (SLP) of a mutated tumour suppressor (TSG). Cell colour shows the strongest known status of that drug for that cancer subtype: approved clinical trial repositionable (potential reuse, no evidence yet) or blank.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
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Showing 200 of 528 drug-target rows in SSL view, for TSG = AXIN1.
Drug TSG SLP (drug target) GBM LUAD SCLC LUSC OAC OSCC PDAC #
sunitinib AXIN1 KIT 7
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab AXIN1 KIT 4
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab AXIN1 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) AXIN1 KIT 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) AXIN1 RET 4
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib AXIN1 KIT 3
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib AXIN1 RET 3
futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan AXIN1 TOP1MT 3
lurbinectedin, irinotecan AXIN1 TOP1MT 3
nivolumab or pembrolizumab (dependent upon approved indication), metformin, rosiglitazone AXIN1 RXRB 3
pembrolizumab, belzutifan, lenvatinib AXIN1 KIT 3
pembrolizumab, belzutifan, lenvatinib AXIN1 RET 3
avapritinib AXIN1 KIT 7
pazopanib AXIN1 KIT 7
regorafenib AXIN1 KIT 7
regorafenib AXIN1 RET 7
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel AXIN1 RET 2
alvocidib, paclitaxel AXIN1 CDK9 2
apatinib, irinotecan AXIN1 TOP1MT 2
asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan AXIN1 TOP1MT 2
asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine AXIN1 TOP1MT 2
bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment AXIN1 KIT 2
biospecimen collection, computed tomography, devimistat, fluorouracil, gemcitabine hydrochloride, hydroxychloroquine, magnetic resonance imaging AXIN1 TLR9 2
bortezomib AXIN1 PSMB5 2
bryostatin 1, paclitaxel AXIN1 PRKCE 2
cabozantinib AXIN1 RET 2
cabozantinib, atezolizumab, cabozantinib, cabozantinib AXIN1 RET 2
carboplatin, celecoxib, paclitaxel, adjuvant therapy, conventional surgery, neoadjuvant therapy AXIN1 CA3 2
cetuximab, cisplatin, irinotecan, radiation therapy, surgery AXIN1 TOP1MT 2
cpt- 11, cisplatin, celecoxib, radiation, surgery AXIN1 CA3 2
entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib AXIN1 RET 2
fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study AXIN1 HDAC3 2
gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a AXIN1 KIT 2
gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a AXIN1 RET 2
inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide AXIN1 TOP1MT 2
irinotecan, capecitabine AXIN1 TOP1MT 2
irinotecan, docetaxel AXIN1 TOP1MT 2
lenvatinib, pembrolizumab AXIN1 KIT 2
lenvatinib, pembrolizumab AXIN1 RET 2
lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate AXIN1 KIT 2
lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate AXIN1 RET 2
ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab AXIN1 TOP1MT 2
melphalan, bcnu, vitamin b12b, vitamin c, ethanol, autologous hematopoietic stem cells AXIN1 CHRNB4 2
mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a AXIN1 KIT 2
mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a AXIN1 RET 2
pembrolizumab, guadecitabine, mocetinostat AXIN1 HDAC3 2
pembrolizumab, lenvatinib AXIN1 KIT 2
pembrolizumab, lenvatinib AXIN1 RET 2
pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu AXIN1 KIT 2
pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu AXIN1 RET 2
pembrolizumab, paclitaxel, docetaxel, irinotecan AXIN1 TOP1MT 2
pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin AXIN1 KIT 2
pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin AXIN1 RET 2
quality-of-life assessment, questionnaire administration, selpercatinib, therapeutic conventional surgery AXIN1 RET 2
regorafenib, laboratory biomarker analysis AXIN1 KIT 2
regorafenib, laboratory biomarker analysis AXIN1 RET 2
sorafenib, administered orally, ct/mri AXIN1 KIT 2
sorafenib, administered orally, ct/mri AXIN1 RET 2
topotecan AXIN1 TOP1MT 2
carfilzomib AXIN1 PSMB5 7
selpercatinib AXIN1 RET 7
sorafenib AXIN1 KIT 7
sorafenib AXIN1 RET 7
vandetanib AXIN1 RET 7
3-dimensional conformal radiation therapy, cognitive assessment, laboratory biomarker analysis, temozolomide, vorinostat AXIN1 HDAC3 1
3-dimensional conformal radiation therapy, intensity-modulated radiation therapy (imrt), temozolomide, chloroquine, tumor treating fields therapy (ttf) AXIN1 TLR9 1
3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, vorinostat AXIN1 HDAC3 1
5 fluorouracil, leucovorin, irinotecan, oxaliplatin AXIN1 TOP1MT 1
9-ing-41, gemcitabine - 21 day cycle, doxorubicin., lomustine, carboplatin., nab paclitaxel., paclitaxel., gemcitabine - 28 day cycle, irinotecan AXIN1 TOP1MT 1
abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf AXIN1 TOP1MT 1
acetazolamide, temozolomide AXIN1 CA3 1
acetazolamide, temozolomide AXIN1 CA14 1
actidose aqua, artesunate, amodiaquine AXIN1 HNMT 1
afatinib, dasatinib, palbociclib, everolimus, olaparib AXIN1 KIT 1
afatinib, irinotecan AXIN1 TOP1MT 1
aldoxorubicin, topotecan AXIN1 TOP1MT 1
alvocidib, docetaxel AXIN1 CDK9 1
alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis AXIN1 CDK9 1
aminolevulinic acid AXIN1 ALAD 1
aminolevulinic acid, surgical resection AXIN1 ALAD 1
amrubicin, topotecan AXIN1 TOP1MT 1
andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel AXIN1 TOP1MT 1
ascorbic acid, paclitaxel protein-bound, cisplatin, gemcitabine AXIN1 EGLN3 1
at-101, topotecan AXIN1 TOP1MT 1
atezolizumab, cabozantinib AXIN1 RET 1
atezolizumab, tivozanib AXIN1 KIT 1
atorvastatin, temozolomide, radiotherapy AXIN1 NR1I3 1
avapritinib, midazolam AXIN1 KIT 1
avastin, bortezomib AXIN1 PSMB5 1
avastin, temozolomide, irinotecan AXIN1 TOP1MT 1
avastin, temozolomide, radiation therapy (xrt), irinotecan AXIN1 TOP1MT 1
avelumab, irinotecan, paclitaxel, best supportive care (bsc) AXIN1 TOP1MT 1
azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab AXIN1 HDAC3 1
azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine AXIN1 TOP1MT 1
bbi608, nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, fluorouracil, mm-398 AXIN1 TOP1MT 1
bemarituzumab, paclitaxel, ramucirumab, bemarituzumab, irinotecan, bemarituzumab, trifluridine/tipiracil AXIN1 TOP1MT 1
berzosertib, computed tomography assisted biopsy, endoscopic biopsy, irinotecan, magnetic resonance imaging AXIN1 TOP1MT 1
bevacizumab [avastin], irinotecan, temozolomide AXIN1 TOP1MT 1
bevacizumab, dasatinib, placebo AXIN1 KIT 1
bevacizumab, irinotecan AXIN1 TOP1MT 1
bevacizumab, irinotecan, dynamic contrast-enhanced magnetic resonance imaging AXIN1 TOP1MT 1
bevacizumab, temozolomide, radiation therapy (xrt), topotecan AXIN1 TOP1MT 1
bevacizumab, temozolomide, vorinostat AXIN1 HDAC3 1
bi 764532, topotecan, single agent chemotherapy AXIN1 TOP1MT 1
binimetinib, hydroxychloroquine AXIN1 TLR9 1
biopsy, biospecimen collection, computed tomography, echocardiography, magnetic resonance imaging, radionuclide imaging, sunitinib AXIN1 KIT 1
biopsy, biospecimen collection, computed tomography, endoscopic ultrasound, fluorouracil, irinotecan, leucovorin, lymph node biopsy, magnetic resonance imaging, oxaliplatin, pembrolizumab, photodynamic therapy, positron emission tomography, questionnaire administration, verteporfin AXIN1 TOP1MT 1
biopsy, biospecimen collection, computed tomography, erdafitinib, magnetic resonance imaging AXIN1 KIT 1
biopsy, biospecimen collection, computed tomography, erdafitinib, magnetic resonance imaging AXIN1 RET 1
biospecimen collection, computed tomography, core biopsy, fluorouracil, irinotecan, leucovorin, leucovorin calcium, oxaliplatin, quemliclustat, zimberelimab AXIN1 TOP1MT 1
biospecimen collection, erdafitinib, magnetic resonance imaging, optical coherence tomography AXIN1 KIT 1
biospecimen collection, erdafitinib, magnetic resonance imaging, optical coherence tomography AXIN1 RET 1
bl-b01d1, irinotecan, paclitaxel, docetaxel AXIN1 TOP1MT 1
bl-b01d1, topotecan AXIN1 TOP1MT 1
bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan AXIN1 TOP1MT 1
bortezomib, carboplatin, paclitaxel AXIN1 PSMB5 1
bortezomib, gemcitabine hydrochloride AXIN1 PSMB5 1
bortezomib, irinotecan AXIN1 PSMB5 1
bortezomib, irinotecan AXIN1 TOP1MT 1
bortezomib, radiation therapy AXIN1 PSMB5 1
bortezomib, temozolomide, pharmacological study AXIN1 PSMB5 1
botensilimab, balstilimab, chloroquine phosphate, celecoxib AXIN1 CA3 1
cabozantinib, durvalumab, tremelimumab AXIN1 RET 1
cabozantinib, nivolumab AXIN1 RET 1
cabozantinib, pembrolizumab AXIN1 RET 1
camrelizumab, docetaxel, irinotecan AXIN1 TOP1MT 1
camrelizumab, irinotecan, paclitaxel, paclitaxel-albumin, docetaxel, anlotinib AXIN1 TOP1MT 1
capecitabine, oxaliplatin, irinotecan AXIN1 TOP1MT 1
capecitabine, vorinostat, radiotherapy, surgery to remove tumor AXIN1 HDAC3 1
carboplatin, irinotecan AXIN1 TOP1MT 1
carboxylesterase-expressing allogeneic neural stem cells, irinotecan, irinotecan hydrochloride, laboratory biomarker analysis, pharmacological study AXIN1 TOP1MT 1
celecoxib, cyclophosphamide, etoposide, thalidomide AXIN1 CA3 1
celecoxib, isotretinoin, temozolomide, thalidomide AXIN1 CA3 1
celecoxib, temozolomide, thalidomide, adjuvant therapy AXIN1 CA3 1
cetuximab, bevacizumab, irinotecan AXIN1 TOP1MT 1
cetuximab, bortezomib AXIN1 PSMB5 1
cetuximab, irinotecan, oxaliplatin, uft AXIN1 TOP1MT 1
chloroquine AXIN1 TLR9 1
chloroquine, radiotherapy, temozolomide AXIN1 TLR9 1
cisplatin, fluorouracil, gemcitabine, irinotecan, leucovorin, nab-paclitaxel, oxaliplatin, radiation therapy AXIN1 TOP1MT 1
cisplatin, gleevec™, irinotecan AXIN1 TOP1MT 1
cisplatin, irinotecan, capecitabine AXIN1 TOP1MT 1
cisplatin, pemetrexed disodium, sorafenib AXIN1 KIT 1
cisplatin, pemetrexed disodium, sorafenib AXIN1 RET 1
cobimetinib, hydroxychloroquine, atezolizumab AXIN1 TLR9 1
cyproheptadine hydrochloride, megestrol acetate AXIN1 PGR 1
dasatinib, erlotinib hydrochloride, gemcitabine hydrochloride AXIN1 KIT 1
dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis, mutation analysis, nucleic acid sequencing, immunohistochemistry staining method AXIN1 KIT 1
dasatinib, laboratory biomarker analysis, physiologic testing AXIN1 KIT 1
dasatinib, mfolfox6 AXIN1 KIT 1
dasatinib, pharmacological study AXIN1 KIT 1
dasatinib, temozolomide, placebo, radiation therapy AXIN1 KIT 1
digoxin, 5fluorouracil, calcium leucovorin, irinotecan, oxaliplatin AXIN1 TOP1MT 1
durvalumab, oxaliplatin, irinotecan, calcium folinate (leucovorin), fluorouracil, pegylated g-csf AXIN1 TOP1MT 1
endoscopic variceal ligation, carvedilol AXIN1 SELE 1
enzastaurin, bevacizumab, enzyme-inducing antiepileptic drugs (eiaed), non-enzyme inducing antiepileptic drugs (neiaed) AXIN1 CHEK1 1
enzastaurin, lomustine AXIN1 CHEK1 1
enzastaurin, temozolomide, radiation therapy AXIN1 CHEK1 1
eras-007, encorafenib, cetuximab, palbociclib AXIN1 MAPK8 1
eras-007, encorafenib, cetuximab, palbociclib AXIN1 LIMK2 1
eras-007, encorafenib, cetuximab, palbociclib AXIN1 STK36 1
erdafitinib AXIN1 KIT 1
erdafitinib AXIN1 RET 1
ethanol, enoxaparin AXIN1 CHRNB4 1
etomidate, midazolam, meperidine AXIN1 GRIN2B 1
etomidate, midazolam, meperidine AXIN1 GRIN2C 1
everolimus, sorafenib AXIN1 KIT 1
everolimus, sorafenib AXIN1 RET 1
fluorouracil, irinotecan, irinotecan hydrochloride, leucovorin, leucovorin calcium, nivolumab, oxaliplatin, therapeutic conventional surgery AXIN1 TOP1MT 1
fluorouracil, leucovorin calcium, oxaliplatin, irinotecan, nivolumab, magnetic resonance imaging, computed tomography, biospecimen collection, questionnaire administration AXIN1 TOP1MT 1
fluorouracil, oxaliplatin, irinotecan AXIN1 TOP1MT 1
gemcitabine, abraxane, hydroxychloroquine AXIN1 TLR9 1
gemcitabine, erlotinib, sorafenib AXIN1 KIT 1
gemcitabine, erlotinib, sorafenib AXIN1 RET 1
gemcitabine, hydroxychloroquine, nab-paclitaxel, paricalcitol AXIN1 TLR9 1
gemcitabine, nab-paclitaxel, irinotecan, intensity-modulated radiation therapy (imrt) AXIN1 TOP1MT 1
gemcitabine, oxaliplatin, imatinib AXIN1 KIT 1
gemcitabine, oxaliplatin, imatinib AXIN1 RET 1
gemcitabine, placebo, sorafenib AXIN1 KIT 1
gemcitabine, placebo, sorafenib AXIN1 RET 1
gemcitabine, sorafenib, radiotherapy AXIN1 KIT 1
gemcitabine, sorafenib, radiotherapy AXIN1 RET 1
gemcitabine, sorafenib, vorinostat, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, rosettesep, depfff AXIN1 KIT 1
gemcitabine, sorafenib, vorinostat, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, rosettesep, depfff AXIN1 HDAC3 1
gemcitabine, sorafenib, vorinostat, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, rosettesep, depfff AXIN1 RET 1
gemcitabine, sunitinib AXIN1 KIT 1
gemcitabine, taxotere, xeloda, cisplatin, irinotecan AXIN1 TOP1MT 1
genistein, erlotinib hydrochloride, gemcitabine hydrochloride AXIN1 ESRRA 1
h101, tislelizumab, lenvatinib AXIN1 KIT 1
h101, tislelizumab, lenvatinib AXIN1 RET 1
hydroxychloroquine, gemcitabine AXIN1 TLR9 1
hydroxychloroquine, radiotherapy AXIN1 TLR9 1
hydroxychloroquine, temozolomide, pharmacological study, radiation AXIN1 TLR9 1
ifinatamab deruxtecan, docetaxel, paclitaxel, irinotecan AXIN1 TOP1MT 1
imatinib, irinotecan, carboplatin AXIN1 KIT 1
imatinib, irinotecan, carboplatin AXIN1 RET 1
imatinib, irinotecan, carboplatin AXIN1 TOP1MT 1
irinotecan hydrochloride liposome injection, topotecan AXIN1 TOP1MT 1
irinotecan, 5-fluorouracil, leucovorin AXIN1 TOP1MT 1
irinotecan, bevacizumab, fdopa-pet/mri imaging AXIN1 TOP1MT 1
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable candidates from cansar.ai — these are potential drug-cancer reuse candidates, not evidence of efficacy.