Drugs that target a gene either directly (oncogene) or via a synthetic-lethal partner (SLP) of a mutated tumour suppressor (TSG). Cell colour shows the strongest known status of that drug for that cancer subtype: approved clinical trial repositionable (potential reuse, no evidence yet) or blank.
| Drug | TSG | SLP (drug target) | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | # |
|---|---|---|---|---|---|---|---|---|---|---|
| sunitinib | VHL | PDGFRA | 5 | |||||||
| sunitinib | VHL | FLT3 | 5 | |||||||
| sunitinib | VHL | MET | 5 | |||||||
| crizotinib | VHL | MET | 5 | |||||||
| bevacizumab | VHL | VEGFA | 3 | |||||||
| gemcitabine | VHL | TYMS | 3 | |||||||
| srf617, gemcitabine, albumin-bound paclitaxel, pembrolizumab | VHL | TYMS | 3 | |||||||
| cabozantinib | VHL | MET | 5 | |||||||
| capecitabine | VHL | TYMS | 5 | |||||||
| everolimus | VHL | MTOR | 5 | |||||||
| nintedanib | VHL | PDGFRA | 5 | |||||||
| nintedanib | VHL | FGFR3 | 5 | |||||||
| palbociclib | VHL | CDK4 | 5 | |||||||
| palbociclib | VHL | CDK6 | 5 | |||||||
| pazopanib | VHL | PDGFRA | 5 | |||||||
| pazopanib | VHL | FGFR3 | 5 | |||||||
| regorafenib | VHL | PDGFRA | 5 | |||||||
| 5fu, nab-paclitaxel, bevacizumab, calcium leucovorin, oxaliplatin | VHL | VEGFA | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | VHL | CDK4 | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | VHL | PDGFRA | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | VHL | MAP2K1 | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | VHL | FGFR3 | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | VHL | CDK6 | 2 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | VHL | MET | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | VHL | MAP2K1 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | VHL | FGFR3 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | VHL | FLT3 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | VHL | MET | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | VHL | IGF1R | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | VHL | TYMS | 2 | |||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | VHL | TYMS | 2 | |||||||
| avelumab, lorlatanib, talazoparib, pemetrexed, axitinib, cmp 001, utomilumab, pf04518600 | VHL | TYMS | 2 | |||||||
| binimetinib, biopsy, biospecimen collection, bone scan, computed tomography, magnetic resonance imaging, palbociclib | VHL | CDK4 | 2 | |||||||
| binimetinib, biopsy, biospecimen collection, bone scan, computed tomography, magnetic resonance imaging, palbociclib | VHL | MAP2K1 | 2 | |||||||
| binimetinib, biopsy, biospecimen collection, bone scan, computed tomography, magnetic resonance imaging, palbociclib | VHL | CDK6 | 2 | |||||||
| capecitabine, temozolomide | VHL | TYMS | 2 | |||||||
| cft1946, trametinib, cetuximab | VHL | MAP2K1 | 2 | |||||||
| cisplatin, pemetrexed, gemcitabine, carboplatin, certolizumab, nivolumab | VHL | TYMS | 2 | |||||||
| cixutumumab, everolimus, laboratory biomarker analysis, octreotide acetate, pharmacological study | VHL | IGF1R | 2 | |||||||
| cixutumumab, everolimus, laboratory biomarker analysis, octreotide acetate, pharmacological study | VHL | MTOR | 2 | |||||||
| cobimetinib, mehd7945a | VHL | MAP2K1 | 2 | |||||||
| dec-205/ny-eso-1 fusion protein cdx-1401, laboratory biomarker analysis, pharmacological study, sirolimus | VHL | MTOR | 2 | |||||||
| eft226, sotorasib, fulvestrant, abemaciclib, trastuzumab | VHL | CDK4 | 2 | |||||||
| eft226, sotorasib, fulvestrant, abemaciclib, trastuzumab | VHL | CDK6 | 2 | |||||||
| entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib | VHL | FLT3 | 2 | |||||||
| inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide | VHL | TYMS | 2 | |||||||
| ioa-244, avelumab injection, pemetrexed, cisplatin, ruxolitinib | VHL | TYMS | 2 | |||||||
| jab-3312, binimetinib, pembrolizumab, sotorasib, osimertinib | VHL | MAP2K1 | 2 | |||||||
| lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate | VHL | PDGFRA | 2 | |||||||
| lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate | VHL | FGFR3 | 2 | |||||||
| mirdametinib, bgb-3245 | VHL | MAP2K1 | 2 | |||||||
| mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed | VHL | TYMS | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | VHL | PDGFRA | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | VHL | FGFR3 | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | VHL | TYMS | 2 | |||||||
| motexafin gadolinium, radiation therapy | VHL | RRM2 | 2 | |||||||
| nab-paclitaxel, gemcitabine | VHL | TYMS | 2 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | VHL | PDGFRA | 2 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | VHL | VEGFA | 2 | |||||||
| nintedanib | VHL | FLT3 | 2 | |||||||
| nintedanib, pembrolizumab | VHL | PDGFRA | 2 | |||||||
| nintedanib, pembrolizumab | VHL | FGFR3 | 2 | |||||||
| nintedanib, pembrolizumab | VHL | FLT3 | 2 | |||||||
| nivolumab, ipilimumab, cobimetinib | VHL | MAP2K1 | 2 | |||||||
| oleclumab, durvalumab, gemcitabine, nab-paclitaxel, oxaliplatin, folinic acid, 5-fu | VHL | TYMS | 2 | |||||||
| osimertinib, bevacizumab, osimertinib | VHL | VEGFA | 2 | |||||||
| pd-1 inhibitor, bevacizumab, carboplatin, cisplatin, pemtrexed | VHL | VEGFA | 2 | |||||||
| pembrolizumab, guadecitabine, mocetinostat | VHL | HDAC2 | 2 | |||||||
| pembrolizumab, lenvatinib | VHL | PDGFRA | 2 | |||||||
| pembrolizumab, lenvatinib | VHL | FGFR3 | 2 | |||||||
| pemetrexed, bevacizumab | VHL | VEGFA | 2 | |||||||
| pemetrexed, bevacizumab | VHL | TYMS | 2 | |||||||
| pharmacological study, romidepsin | VHL | HDAC2 | 2 | |||||||
| regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) | VHL | PDGFRA | 2 | |||||||
| regorafenib, laboratory biomarker analysis | VHL | PDGFRA | 2 | |||||||
| selumetinib, medi4736, tremelimumab | VHL | MAP2K1 | 2 | |||||||
| sy-5609, fulvestrant, gemcitabine, nab-paclitaxel | VHL | TYMS | 2 | |||||||
| temsirolimus | VHL | MTOR | 2 | |||||||
| temsirolimus, laboratory biomarker analysis | VHL | MTOR | 2 | |||||||
| tislelizumab, pemetrexed | VHL | TYMS | 2 | |||||||
| tivantinib | VHL | MET | 2 | |||||||
| whole brain low dose radiotherapy, pemetrexed, sintilimab, chemotherapy | VHL | TYMS | 2 | |||||||
| binimetinib | VHL | MAP2K1 | 5 | |||||||
| pemetrexed | VHL | TYMS | 5 | |||||||
| pemigatinib | VHL | FGFR3 | 5 | |||||||
| ribociclib | VHL | CDK4 | 5 | |||||||
| ribociclib | VHL | CDK6 | 5 | |||||||
| romidepsin | VHL | HDAC2 | 5 | |||||||
| selumetinib | VHL | MAP2K1 | 5 | |||||||
| sorafenib | VHL | FLT3 | 5 | |||||||
| trilaciclib | VHL | CDK4 | 5 | |||||||
| trilaciclib | VHL | CDK6 | 5 | |||||||
| 3-dimensional conformal radiation therapy, bevacizumab, cisplatin, fluorouracil, intensity-modulated radiation therapy | VHL | VEGFA | 1 | |||||||
| 3-dimensional conformal radiation therapy, bevacizumab, cisplatin, fluorouracil, intensity-modulated radiation therapy | VHL | TYMS | 1 | |||||||
| 3-dimensional conformal radiation therapy, bevacizumab, intensity-modulated radiation therapy, laboratory biomarker analysis, placebo, quality-of-life assessment, temozolomide | VHL | VEGFA | 1 | |||||||
| 3-dimensional conformal radiation therapy, biospecimen collection, capecitabine, chemotherapy, computed tomography, erlotinib hydrochloride, fluorouracil, gemcitabine hydrochloride, intensity-modulated radiation therapy, magnetic resonance imaging, quality-of-life assessment, x-ray imaging | VHL | TYMS | 1 | |||||||
| 3-dimensional conformal radiation therapy, cognitive assessment, laboratory biomarker analysis, temozolomide, vorinostat | VHL | HDAC2 | 1 | |||||||
| 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, vorinostat | VHL | HDAC2 | 1 | |||||||
| 3-dimensional conformal radiation therapy, motexafin gadolinium, temozolomide | VHL | RRM2 | 1 | |||||||
| 4-dimensional computed tomography, fluorouracil, gemcitabine hydrochloride, laboratory biomarker analysis, leucovorin calcium, nelfinavir mesylate, oregovomab, stereotactic body radiation therapy, therapeutic conventional surgery | VHL | TYMS | 1 | |||||||
| 5-fu, atezolizumab, bevacizumab, gemcitabine, leucovorin, nab-paclitaxel, oxaliplatin, capecitabine, cisplatin | VHL | VEGFA | 1 | |||||||
| 5-fu, atezolizumab, bevacizumab, gemcitabine, leucovorin, nab-paclitaxel, oxaliplatin, capecitabine, cisplatin | VHL | TYMS | 1 | |||||||
| 6,8-bis(benzylthio)octanoic acid, oxaliplatin, leucovorin calcium, irinotecan hydrochloride, fluorouracil, laboratory biomarker analysis | VHL | TYMS | 1 | |||||||
| 7-hydroxystaurosporine, fluorouracil | VHL | TYMS | 1 | |||||||
| 9-ing-41, retifanlimab, gemcitabine, abraxane | VHL | TYMS | 1 | |||||||
| ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine | VHL | VEGFA | 1 | |||||||
| ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine | VHL | TYMS | 1 | |||||||
| abemaciclib, abemaciclib | VHL | CDK4 | 1 | |||||||
| abemaciclib, abemaciclib | VHL | CDK6 | 1 | |||||||
| abemaciclib, bevacizumab | VHL | CDK4 | 1 | |||||||
| abemaciclib, bevacizumab | VHL | CDK6 | 1 | |||||||
| abemaciclib, bevacizumab | VHL | VEGFA | 1 | |||||||
| abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf | VHL | CDK4 | 1 | |||||||
| abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf | VHL | CDK6 | 1 | |||||||
| abemaciclib, ly3023414, gemcitabine, capecitabine | VHL | CDK4 | 1 | |||||||
| abemaciclib, ly3023414, gemcitabine, capecitabine | VHL | CDK6 | 1 | |||||||
| abemaciclib, ly3023414, gemcitabine, capecitabine | VHL | TYMS | 1 | |||||||
| abemaciclib, ly3214996 | VHL | CDK4 | 1 | |||||||
| abemaciclib, ly3214996 | VHL | CDK6 | 1 | |||||||
| abemaciclib, surgery | VHL | CDK4 | 1 | |||||||
| abemaciclib, surgery | VHL | CDK6 | 1 | |||||||
| abraxane (nab-paclitaxel), gemcitabine | VHL | TYMS | 1 | |||||||
| adct-601, gemcitabine | VHL | TYMS | 1 | |||||||
| adjuvant therapy, temozolomide, valproic acid, radiation therapy | VHL | HDAC2 | 1 | |||||||
| adriamycin, cyclophosphamide, vindesine, valproic acid | VHL | HDAC2 | 1 | |||||||
| aee788, everolimus | VHL | MTOR | 1 | |||||||
| afatinib dimaleate, capecitabine, laboratory biomarker analysis | VHL | TYMS | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | VHL | CDK4 | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | VHL | CDK6 | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | VHL | MTOR | 1 | |||||||
| ag-013736, gemcitabine, gemcitabine, placebo | VHL | TYMS | 1 | |||||||
| agen1423, botensilimab, gemcitabine, nab-paclitaxel | VHL | TYMS | 1 | |||||||
| ags-1c4d4, gemcitabine | VHL | TYMS | 1 | |||||||
| ak104, ak104, gemcitabine, nab-paclitaxel | VHL | TYMS | 1 | |||||||
| ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, nab-paclitaxel, gemcitabine, nab-paclitaxel, gemcitabine | VHL | TYMS | 1 | |||||||
| akt inhibitor mk2206, fluorouracil, oxaliplatin, selumetinib | VHL | MAP2K1 | 1 | |||||||
| akt inhibitor mk2206, fluorouracil, oxaliplatin, selumetinib | VHL | TYMS | 1 | |||||||
| albumin-bound paclitaxel (abi-007), gemcitabine | VHL | TYMS | 1 | |||||||
| aldesleukin, antibody therapy, fluorouracil, gemcitabine hydrochloride, irinotecan hydrochloride, laboratory biomarker analysis, leucovorin calcium, oxaliplatin, paclitaxel albumin-stabilized nanoparticle formulation, sargramostim | VHL | TYMS | 1 | |||||||
| alisertib, gemcitabine | VHL | TYMS | 1 | |||||||
| alpelisib, everolimus, exemestane | VHL | MTOR | 1 | |||||||
| alvocidib, docetaxel | VHL | CDK4 | 1 | |||||||
| alvocidib, docetaxel | VHL | CDK6 | 1 | |||||||
| alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis | VHL | CDK4 | 1 | |||||||
| alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis | VHL | CDK6 | 1 | |||||||
| amg 193, gemcitabine, nab-paclitaxel, modified folfirinox | VHL | TYMS | 1 | |||||||
| amg 479, placebo, amg 479, gemcitabine | VHL | TYMS | 1 | |||||||
| amgen 386, bevacizumab | VHL | VEGFA | 1 | |||||||
| amivantamab | VHL | MET | 1 | |||||||
| andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel | VHL | VEGFA | 1 | |||||||
| andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel | VHL | TYMS | 1 | |||||||
| anetumab ravtansine, bevacizumab, paclitaxel | VHL | VEGFA | 1 | |||||||
| ang1005, bevacizumab | VHL | VEGFA | 1 | |||||||
| anti-endoglin chimeric monoclonal antibody trc105, bevacizumab, laboratory biomarker analysis, pharmacological study, quality-of-life assessment | VHL | VEGFA | 1 | |||||||
| apg-1387 for injection, gemcitabine, nab paclitaxel | VHL | TYMS | 1 | |||||||
| apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib | VHL | CDK4 | 1 | |||||||
| apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib | VHL | CDK6 | 1 | |||||||
| apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib | VHL | MTOR | 1 | |||||||
| aprepitant, gemcitabine hydrochloride, capecitabine, fluorouracil, radiation therapy, questionnaire administration, quality-of-life assessment, nausea and vomiting therapy, management of therapy complications | VHL | TYMS | 1 | |||||||
| apx005m, nivolumab, nab-paclitaxel, gemcitabine | VHL | TYMS | 1 | |||||||
| arq 197, gemcitabine | VHL | TYMS | 1 | |||||||
| asc40 tablets, placebo tablets, bevacizumab | VHL | VEGFA | 1 | |||||||
| ascorbate, nab paclitaxel, gemcitabine | VHL | TYMS | 1 | |||||||
| ascorbic acid, paclitaxel protein-bound, cisplatin, gemcitabine | VHL | TYMS | 1 | |||||||
| asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan | VHL | TYMS | 1 | |||||||
| atezolizumab injection, bevacizumab, transarterial chemoembolization | VHL | VEGFA | 1 | |||||||
| atezolizumab, bevacizumab | VHL | VEGFA | 1 | |||||||
| atezolizumab, bevacizumab, laboratory biomarker analysis, pharmacological study | VHL | VEGFA | 1 | |||||||
| atezolizumab, cabozantinib | VHL | MET | 1 | |||||||
| atezolizumab, tivozanib | VHL | PDGFRA | 1 | |||||||
| atezolizumab, tivozanib | VHL | FLT3 | 1 | |||||||
| atezolizumab, tivozanib | VHL | MET | 1 | |||||||
| atorvastatin, temozolomide, radiotherapy | VHL | HDAC2 | 1 | |||||||
| atra, gemcitabine, nab-paclitaxel | VHL | TYMS | 1 | |||||||
| avastin (bevacizumab), gemcitabine, radiation therapy | VHL | TYMS | 1 | |||||||
| azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab | VHL | HDAC2 | 1 | |||||||
| azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab | VHL | TYMS | 1 | |||||||
| azd0171, durvalumab, gemcitabine, nab-paclitaxel | VHL | TYMS | 1 | |||||||
| azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine | VHL | TYMS | 1 | |||||||
| azd1775, gemcitabine, nab-paclitaxel | VHL | TYMS | 1 | |||||||
| azd5335, saruparib (azd5305), bevacizumab, carboplatin | VHL | VEGFA | 1 | |||||||
| azd6244, dacarbazine, erlotinib, docetaxel, temsirolimus | VHL | MTOR | 1 | |||||||
| bbi608, nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, fluorouracil, mm-398 | VHL | TYMS | 1 | |||||||
| bethanechol, gemcitabine, nab-paclitaxel | VHL | TYMS | 1 | |||||||
| bevacizumab, bevacizumab | VHL | VEGFA | 1 | |||||||
| bevacizumab, biopsy, biospecimen collection, computed tomography, magnetic resonance imaging, osimertinib | VHL | VEGFA | 1 | |||||||
| bevacizumab, biospecimen collection, computed tomography, electronic health record review, hypofractionated radiation therapy, magnetic resonance imaging, retifanlimab | VHL | VEGFA | 1 | |||||||
| bevacizumab, bkm120 | VHL | VEGFA | 1 | |||||||
| bevacizumab, capecitabine, gemcitabine hydrochloride | VHL | VEGFA | 1 | |||||||
| bevacizumab, capecitabine, gemcitabine hydrochloride | VHL | TYMS | 1 | |||||||
| bevacizumab, capecitabine/oxaliplatin, fluorouracil/folinic acid/oxaliplatin, capecitabine, fluorouracil/folinic acid/irinotecan, fluorouracil +/- folinic acid | VHL | VEGFA | 1 | |||||||
| bevacizumab, capecitabine/oxaliplatin, fluorouracil/folinic acid/oxaliplatin, capecitabine, fluorouracil/folinic acid/irinotecan, fluorouracil +/- folinic acid | VHL | TYMS | 1 | |||||||
| bevacizumab, carmustine | VHL | VEGFA | 1 | |||||||
| bevacizumab, cediranib maleate | VHL | VEGFA | 1 | |||||||
| bevacizumab, cediranib, cediranib maleate, olaparib | VHL | VEGFA | 1 | |||||||
| bevacizumab, chemotherapy, fractionated radiosurgery | VHL | VEGFA | 1 | |||||||
| bevacizumab, chest radiation, concurrent chemotherapy | VHL | VEGFA | 1 | |||||||
| bevacizumab, cisplatin, etoposide, radiation therapy | VHL | VEGFA | 1 | |||||||
| bevacizumab, cisplatin, gemcitabine hydrochloride | VHL | VEGFA | 1 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | VHL | VEGFA | 1 |