Drugs that target a gene either directly (oncogene) or via a synthetic-lethal partner (SLP) of a mutated tumour suppressor (TSG). Cell colour shows the strongest known status of that drug for that cancer subtype: approved clinical trial repositionable (potential reuse, no evidence yet) or blank.
| Drug | TSG | SLP (drug target) | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | # |
|---|---|---|---|---|---|---|---|---|---|---|
| olaparib | PIK3R1 | PARP1 | 1 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | PIK3R1 | ABL1 | 4 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | PIK3R1 | CTLA4 | 4 | |||||||
| nivolumab, ipilimumab | PIK3R1 | CTLA4 | 4 | |||||||
| paclitaxel + carboplatin, carboplatin + etoposide, gemcitabine + carboplatin, nab-paclitaxel (paclitaxel-albumin) + carboplatin, oxaliplatin + 5-fluorouracil (5fu) + leucovorin (calcium folinate/folinic acid), durvalumab, tremelimumab, nab-paclitaxel (paclitaxel-albumin) + gemcitabine, cisplatin + 5-fluorouracil (5fu) | PIK3R1 | CTLA4 | 4 | |||||||
| regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) | PIK3R1 | ABL1 | 4 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | PIK3R1 | ABL1 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | PIK3R1 | CDK6 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | PIK3R1 | WEE1 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | PIK3R1 | SMO | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | PIK3R1 | FGFR4 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | PIK3R1 | MAP2K1 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | PIK3R1 | FGFR3 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | PIK3R1 | BTK | 3 | |||||||
| biospecimen collection, computed tomography, echocardiography, ipilimumab, magnetic resonance imaging, nivolumab | PIK3R1 | CTLA4 | 3 | |||||||
| dec-205/ny-eso-1 fusion protein cdx-1401, laboratory biomarker analysis, pharmacological study, sirolimus | PIK3R1 | MTOR | 3 | |||||||
| futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan | PIK3R1 | FGFR4 | 3 | |||||||
| futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan | PIK3R1 | FGFR3 | 3 | |||||||
| nivolumab or pembrolizumab (dependent upon approved indication), metformin, rosiglitazone | PIK3R1 | RXRB | 3 | |||||||
| pembrolizumab, belzutifan, lenvatinib | PIK3R1 | FGFR4 | 3 | |||||||
| pembrolizumab, belzutifan, lenvatinib | PIK3R1 | FGFR3 | 3 | |||||||
| abemaciclib | PIK3R1 | CDK6 | 7 | |||||||
| everolimus | PIK3R1 | MTOR | 7 | |||||||
| ibrutinib | PIK3R1 | BTK | 7 | |||||||
| nintedanib | PIK3R1 | FGFR3 | 7 | |||||||
| palbociclib | PIK3R1 | CDK6 | 7 | |||||||
| pazopanib | PIK3R1 | FGFR3 | 7 | |||||||
| regorafenib | PIK3R1 | ABL1 | 7 | |||||||
| adavosertib, radiation therapy | PIK3R1 | WEE1 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | PIK3R1 | ABL1 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | PIK3R1 | MAP2K1 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | PIK3R1 | FGFR3 | 2 | |||||||
| alvocidib, paclitaxel | PIK3R1 | CDK9 | 2 | |||||||
| alvocidib, paclitaxel | PIK3R1 | CDK6 | 2 | |||||||
| bbi-355, erlotinib, futibatinib | PIK3R1 | FGFR4 | 2 | |||||||
| bbi-355, erlotinib, futibatinib | PIK3R1 | FGFR3 | 2 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | PIK3R1 | ABL1 | 2 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | PIK3R1 | BTK | 2 | |||||||
| binimetinib, biopsy, biospecimen collection, bone scan, computed tomography, magnetic resonance imaging, palbociclib | PIK3R1 | CDK6 | 2 | |||||||
| binimetinib, biopsy, biospecimen collection, bone scan, computed tomography, magnetic resonance imaging, palbociclib | PIK3R1 | MAP2K1 | 2 | |||||||
| bms-986207, nivolumab, ipilimumab | PIK3R1 | CTLA4 | 2 | |||||||
| cft1946, trametinib, cetuximab | PIK3R1 | MAP2K1 | 2 | |||||||
| cixutumumab, everolimus, laboratory biomarker analysis, octreotide acetate, pharmacological study | PIK3R1 | MTOR | 2 | |||||||
| cobimetinib, mehd7945a | PIK3R1 | MAP2K1 | 2 | |||||||
| durvalumab, tremelimumab, oxaliplatin, capecitabine, radiotherapy, paclitaxel, carboplatin, 5-fluorouracil (5-fu), leucovorin, docetaxel | PIK3R1 | CTLA4 | 2 | |||||||
| durvalumab, tremelimumab, sbrt | PIK3R1 | CTLA4 | 2 | |||||||
| eft226, sotorasib, fulvestrant, abemaciclib, trastuzumab | PIK3R1 | CDK6 | 2 | |||||||
| entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib | PIK3R1 | JAK2 | 2 | |||||||
| fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study | PIK3R1 | HDAC3 | 2 | |||||||
| fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study | PIK3R1 | HDAC2 | 2 | |||||||
| gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a | PIK3R1 | FGFR4 | 2 | |||||||
| gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a | PIK3R1 | FGFR3 | 2 | |||||||
| ioa-244, avelumab injection, pemetrexed, cisplatin, ruxolitinib | PIK3R1 | JAK2 | 2 | |||||||
| ipilimumab | PIK3R1 | CTLA4 | 2 | |||||||
| jab-3312, binimetinib, pembrolizumab, sotorasib, osimertinib | PIK3R1 | MAP2K1 | 2 | |||||||
| lenvatinib, pembrolizumab | PIK3R1 | FGFR4 | 2 | |||||||
| lenvatinib, pembrolizumab | PIK3R1 | FGFR3 | 2 | |||||||
| lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate | PIK3R1 | FGFR4 | 2 | |||||||
| lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate | PIK3R1 | FGFR3 | 2 | |||||||
| ly3022855, durvalumab, tremelimumab | PIK3R1 | CTLA4 | 2 | |||||||
| mirdametinib, bgb-3245 | PIK3R1 | MAP2K1 | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | PIK3R1 | FGFR4 | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | PIK3R1 | FGFR3 | 2 | |||||||
| motexafin gadolinium, radiation therapy | PIK3R1 | RRM2 | 2 | |||||||
| nintedanib, pembrolizumab | PIK3R1 | FGFR3 | 2 | |||||||
| nivolumab, ipilimumab, cobimetinib | PIK3R1 | CTLA4 | 2 | |||||||
| nivolumab, ipilimumab, cobimetinib | PIK3R1 | MAP2K1 | 2 | |||||||
| olaparib | PIK3R1 | PARP3 | 2 | |||||||
| pembrolizumab, guadecitabine, mocetinostat | PIK3R1 | HDAC3 | 2 | |||||||
| pembrolizumab, guadecitabine, mocetinostat | PIK3R1 | HDAC2 | 2 | |||||||
| pembrolizumab, lenvatinib | PIK3R1 | FGFR4 | 2 | |||||||
| pembrolizumab, lenvatinib | PIK3R1 | FGFR3 | 2 | |||||||
| pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu | PIK3R1 | FGFR4 | 2 | |||||||
| pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu | PIK3R1 | FGFR3 | 2 | |||||||
| pembrolizumab, sonidegib | PIK3R1 | SMO | 2 | |||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | PIK3R1 | FGFR4 | 2 | |||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | PIK3R1 | FGFR3 | 2 | |||||||
| pharmacological study, romidepsin | PIK3R1 | ABCC1 | 2 | |||||||
| pharmacological study, romidepsin | PIK3R1 | HDAC4 | 2 | |||||||
| pharmacological study, romidepsin | PIK3R1 | HDAC2 | 2 | |||||||
| quality-of-life assessment, questionnaire administration, selpercatinib, therapeutic conventional surgery | PIK3R1 | FGFR3 | 2 | |||||||
| regorafenib, laboratory biomarker analysis | PIK3R1 | ABL1 | 2 | |||||||
| selumetinib, medi4736, tremelimumab | PIK3R1 | CTLA4 | 2 | |||||||
| selumetinib, medi4736, tremelimumab | PIK3R1 | MAP2K1 | 2 | |||||||
| stereotactic body radiotherapy, ipilimumab, nivolumab, pembrolizumab or atezolizumab | PIK3R1 | CTLA4 | 2 | |||||||
| temsirolimus | PIK3R1 | MTOR | 2 | |||||||
| temsirolimus, laboratory biomarker analysis | PIK3R1 | MTOR | 2 | |||||||
| trabectedin, ipilimumab, nivolumab | PIK3R1 | CTLA4 | 2 | |||||||
| bethanechol | PIK3R1 | CHRM1 | 7 | |||||||
| binimetinib | PIK3R1 | MAP2K1 | 7 | |||||||
| bosutinib | PIK3R1 | ABL1 | 7 | |||||||
| entrectinib | PIK3R1 | JAK2 | 7 | |||||||
| erdafitinib | PIK3R1 | FGFR4 | 7 | |||||||
| erdafitinib | PIK3R1 | FGFR3 | 7 | |||||||
| pemigatinib | PIK3R1 | FGFR3 | 7 | |||||||
| ponatinib | PIK3R1 | ABL1 | 7 | |||||||
| ribociclib | PIK3R1 | CDK6 | 7 | |||||||
| romidepsin | PIK3R1 | HDAC2 | 7 | |||||||
| ruxolitinib | PIK3R1 | JAK2 | 7 | |||||||
| selumetinib | PIK3R1 | MAP2K1 | 7 | |||||||
| trilaciclib | PIK3R1 | CDK6 | 7 | |||||||
| 18f-fluoromisonidazole, cediranib maleate, laboratory biomarker analysis, olaparib, positron emission tomography | PIK3R1 | PARP3 | 1 | |||||||
| 3-dimensional conformal radiation therapy, cognitive assessment, laboratory biomarker analysis, temozolomide, vorinostat | PIK3R1 | HDAC3 | 1 | |||||||
| 3-dimensional conformal radiation therapy, cognitive assessment, laboratory biomarker analysis, temozolomide, vorinostat | PIK3R1 | HDAC2 | 1 | |||||||
| 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, vorinostat | PIK3R1 | HDAC3 | 1 | |||||||
| 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, vorinostat | PIK3R1 | HDAC2 | 1 | |||||||
| 3-dimensional conformal radiation therapy, motexafin gadolinium, temozolomide | PIK3R1 | RRM2 | 1 | |||||||
| 5-fluorouracil (5-fu), leucovorin, oxaliplatin, atezolizumab, cobimetinib, ramucirumab, paclitaxel, pegylated recombinant human hyaluronidase (pegph20), bl-8040, linagliptin, atezolizumab, cobimetinib, cisplatin, tiragolumab, 5-fluorouracil (5-fu) | PIK3R1 | MAP2K1 | 1 | |||||||
| abemaciclib, abemaciclib | PIK3R1 | CDK6 | 1 | |||||||
| abemaciclib, bevacizumab | PIK3R1 | CDK6 | 1 | |||||||
| abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf | PIK3R1 | CDK6 | 1 | |||||||
| abemaciclib, ly3023414, gemcitabine, capecitabine | PIK3R1 | CDK6 | 1 | |||||||
| abemaciclib, ly3214996 | PIK3R1 | CDK6 | 1 | |||||||
| abemaciclib, surgery | PIK3R1 | CDK6 | 1 | |||||||
| adavosertib | PIK3R1 | WEE1 | 1 | |||||||
| adavosertib, laboratory biomarker analysis, pharmacological study, radiation therapy | PIK3R1 | WEE1 | 1 | |||||||
| adavosertib, radiation therapy, temozolomide | PIK3R1 | WEE1 | 1 | |||||||
| adjuvant therapy, temozolomide, valproic acid, radiation therapy | PIK3R1 | HDAC2 | 1 | |||||||
| adriamycin, cyclophosphamide, vindesine, valproic acid | PIK3R1 | HDAC2 | 1 | |||||||
| aee788, everolimus | PIK3R1 | MTOR | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | PIK3R1 | PARP3 | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | PIK3R1 | ABL1 | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | PIK3R1 | CDK6 | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | PIK3R1 | BTK | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | PIK3R1 | MTOR | 1 | |||||||
| akt inhibitor mk2206, fluorouracil, oxaliplatin, selumetinib | PIK3R1 | MAP2K1 | 1 | |||||||
| alpelisib, everolimus, exemestane | PIK3R1 | MTOR | 1 | |||||||
| alvocidib, docetaxel | PIK3R1 | CDK9 | 1 | |||||||
| alvocidib, docetaxel | PIK3R1 | CDK6 | 1 | |||||||
| alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis | PIK3R1 | CDK9 | 1 | |||||||
| alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis | PIK3R1 | CDK6 | 1 | |||||||
| anetumab ravtansine, biopsy, biospecimen collection, gemcitabine hydrochloride, ipilimumab, nivolumab | PIK3R1 | CTLA4 | 1 | |||||||
| anti-sema4d monoclonal antibody vx15/2503, ipilimumab, nivolumab, surgery | PIK3R1 | CTLA4 | 1 | |||||||
| apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib | PIK3R1 | CDK6 | 1 | |||||||
| apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib | PIK3R1 | SMO | 1 | |||||||
| apg101, alectinib, idasanutlin, atezolizumab, vismodegib, temsirolimus, palbociclib | PIK3R1 | MTOR | 1 | |||||||
| arsenic trioxide | PIK3R1 | IKBKB | 1 | |||||||
| arsenic trioxide, radiation therapy | PIK3R1 | IKBKB | 1 | |||||||
| arsenic trioxide, temozolomide, adjuvant therapy, intensity-modulated radiation therapy, radiation therapy | PIK3R1 | IKBKB | 1 | |||||||
| atorvastatin, temozolomide, radiotherapy | PIK3R1 | HDAC2 | 1 | |||||||
| azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab | PIK3R1 | DNMT1 | 1 | |||||||
| azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab | PIK3R1 | HDAC3 | 1 | |||||||
| azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab | PIK3R1 | HDAC2 | 1 | |||||||
| azd1775, olaparib | PIK3R1 | PARP3 | 1 | |||||||
| azd6244, dacarbazine, erlotinib, docetaxel, temsirolimus | PIK3R1 | MTOR | 1 | |||||||
| bethanechol, gemcitabine, nab-paclitaxel | PIK3R1 | CHRM1 | 1 | |||||||
| bevacizumab, cediranib, cediranib maleate, olaparib | PIK3R1 | PARP3 | 1 | |||||||
| bevacizumab, dasatinib, placebo | PIK3R1 | ABL1 | 1 | |||||||
| bevacizumab, dasatinib, placebo | PIK3R1 | BTK | 1 | |||||||
| bevacizumab, everolimus, octreotide acetate | PIK3R1 | MTOR | 1 | |||||||
| bevacizumab, temozolomide, vorinostat | PIK3R1 | HDAC3 | 1 | |||||||
| bevacizumab, temozolomide, vorinostat | PIK3R1 | HDAC2 | 1 | |||||||
| bevacizumab, temsirolimus | PIK3R1 | MTOR | 1 | |||||||
| binimetinib, hydroxychloroquine | PIK3R1 | MAP2K1 | 1 | |||||||
| biopsy, biospecimen collection, computed tomography, erdafitinib, magnetic resonance imaging | PIK3R1 | FGFR4 | 1 | |||||||
| biopsy, biospecimen collection, computed tomography, erdafitinib, magnetic resonance imaging | PIK3R1 | FGFR3 | 1 | |||||||
| biopsy, biospecimen collection, computed tomography, magnetic resonance imaging, olaparib | PIK3R1 | PARP3 | 1 | |||||||
| biopsy, biospecimen collection, computed tomography, magnetic resonance imaging, olaparib, pembrolizumab | PIK3R1 | PARP3 | 1 | |||||||
| biopsy, biospecimen collection, computed tomography, magnetic resonance imaging, palbociclib | PIK3R1 | CDK6 | 1 | |||||||
| biopsy, biospecimen collection, echocardiography, radionuclide imaging, vismodegib | PIK3R1 | SMO | 1 | |||||||
| biopsy, calaspargase pegol-mknl, cobimetinib | PIK3R1 | MAP2K1 | 1 | |||||||
| biospecimen collection, computed tomography, magnetic resonance imaging, olaparib, placebo administration | PIK3R1 | PARP3 | 1 | |||||||
| biospecimen collection, erdafitinib, magnetic resonance imaging, optical coherence tomography | PIK3R1 | FGFR4 | 1 | |||||||
| biospecimen collection, erdafitinib, magnetic resonance imaging, optical coherence tomography | PIK3R1 | FGFR3 | 1 | |||||||
| blu-222, carboplatin, ribociclib, fulvestrant | PIK3R1 | CDK6 | 1 | |||||||
| bosutinib | PIK3R1 | MAP2K1 | 1 | |||||||
| byl719, poziotinib, nintedanib, abemaciclib, durvalumab,tremelimumab | PIK3R1 | CDK6 | 1 | |||||||
| byl719, poziotinib, nintedanib, abemaciclib, durvalumab,tremelimumab | PIK3R1 | FGFR3 | 1 | |||||||
| cabozantinib, durvalumab, tremelimumab | PIK3R1 | CTLA4 | 1 | |||||||
| capecitabine, medi4736 (durvalumab), trastuzumab, rucaparib, ramucirumab | PIK3R1 | PARP3 | 1 | |||||||
| capecitabine, vorinostat, radiotherapy, surgery to remove tumor | PIK3R1 | HDAC3 | 1 | |||||||
| capecitabine, vorinostat, radiotherapy, surgery to remove tumor | PIK3R1 | HDAC2 | 1 | |||||||
| ce-mark approved laa closure devices, acetylsalicylic acid, clopidogrel, dabigatran, rivaroxaban, apixaban, edoxaban, phenprocoumon, warfarin | PIK3R1 | IKBKB | 1 | |||||||
| ceralasertib, olaparib, durvalumab | PIK3R1 | PARP3 | 1 | |||||||
| chemotherapy, cladribine, radiation therapy | PIK3R1 | RRM2 | 1 | |||||||
| chlorpromazine, temozolomide, radiation therapy | PIK3R1 | CHRM1 | 1 | |||||||
| cobimetinib, hydroxychloroquine, atezolizumab | PIK3R1 | MAP2K1 | 1 | |||||||
| cobimetinib, olaparib, onvansertib, azenosertib, saruparib, tremelimumab | PIK3R1 | PARP3 | 1 | |||||||
| cobimetinib, olaparib, onvansertib, azenosertib, saruparib, tremelimumab | PIK3R1 | CTLA4 | 1 | |||||||
| cobimetinib, olaparib, onvansertib, azenosertib, saruparib, tremelimumab | PIK3R1 | MAP2K1 | 1 | |||||||
| contrast-enhanced magnetic resonance imaging, ipilimumab, nivolumab, novottf-100a device, quality-of-life assessment, questionnaire administration, radiation therapy, temozolomide | PIK3R1 | CTLA4 | 1 | |||||||
| conventional surgery, 3-dimensional conformal radiation therapy, stereotactic radiosurgery, motexafin gadolinium, magnetic resonance imaging, spectroscopy | PIK3R1 | RRM2 | 1 | |||||||
| conventional surgery, laboratory biomarker analysis, sorafenib tosylate, temsirolimus | PIK3R1 | MTOR | 1 | |||||||
| cyclophosphamide, nivolumab, ipilimumab, gvax pancreas vaccine, crs-207, crs-207 | PIK3R1 | CTLA4 | 1 | |||||||
| cytoreductive surgery, perifosine, temsirolimus | PIK3R1 | MTOR | 1 | |||||||
| dabrafenib, trametinib | PIK3R1 | MAP2K1 | 1 | |||||||
| dabrafenib, trametinib, carboplatin, vincristine | PIK3R1 | MAP2K1 | 1 | |||||||
| dasatinib, erlotinib hydrochloride, gemcitabine hydrochloride | PIK3R1 | ABL1 | 1 | |||||||
| dasatinib, erlotinib hydrochloride, gemcitabine hydrochloride | PIK3R1 | BTK | 1 | |||||||
| dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis, mutation analysis, nucleic acid sequencing, immunohistochemistry staining method | PIK3R1 | ABL1 | 1 | |||||||
| dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis, mutation analysis, nucleic acid sequencing, immunohistochemistry staining method | PIK3R1 | BTK | 1 | |||||||
| dasatinib, laboratory biomarker analysis, physiologic testing | PIK3R1 | ABL1 | 1 | |||||||
| dasatinib, laboratory biomarker analysis, physiologic testing | PIK3R1 | BTK | 1 | |||||||
| dasatinib, mfolfox6 | PIK3R1 | ABL1 | 1 | |||||||
| dasatinib, mfolfox6 | PIK3R1 | BTK | 1 | |||||||
| dasatinib, pharmacological study | PIK3R1 | ABL1 | 1 | |||||||
| dasatinib, pharmacological study | PIK3R1 | BTK | 1 | |||||||
| dasatinib, temozolomide, placebo, radiation therapy | PIK3R1 | ABL1 | 1 | |||||||
| dasatinib, temozolomide, placebo, radiation therapy | PIK3R1 | BTK | 1 | |||||||
| decitabine, gemcitabine | PIK3R1 | DNMT1 | 1 |