Drugs that target a gene either directly (oncogene) or via a synthetic-lethal partner (SLP) of a mutated tumour suppressor (TSG). Cell colour shows the strongest known status of that drug for that cancer subtype: approved clinical trial repositionable (potential reuse, no evidence yet) or blank.
| Drug | TSG | SLP (drug target) | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | # |
|---|---|---|---|---|---|---|---|---|---|---|
| olaparib | BRCA2 | PARP2 | 1 | |||||||
| olaparib | BRCA2 | PARP1 | 1 | |||||||
| sunitinib | BRCA2 | KIT | 7 | |||||||
| sunitinib | BRCA2 | FLT3 | 7 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | BRCA2 | RET | 4 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | BRCA2 | CTLA4 | 4 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | BRCA2 | ABL1 | 4 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | BRCA2 | KIT | 4 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | BRCA2 | FGFR2 | 4 | |||||||
| nivolumab, ipilimumab | BRCA2 | CTLA4 | 4 | |||||||
| paclitaxel + carboplatin, carboplatin + etoposide, gemcitabine + carboplatin, nab-paclitaxel (paclitaxel-albumin) + carboplatin, oxaliplatin + 5-fluorouracil (5fu) + leucovorin (calcium folinate/folinic acid), durvalumab, tremelimumab, nab-paclitaxel (paclitaxel-albumin) + gemcitabine, cisplatin + 5-fluorouracil (5fu) | BRCA2 | CTLA4 | 4 | |||||||
| regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) | BRCA2 | RET | 4 | |||||||
| regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) | BRCA2 | ABL1 | 4 | |||||||
| regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) | BRCA2 | KIT | 4 | |||||||
| regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) | BRCA2 | FGFR2 | 4 | |||||||
| ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine | BRCA2 | TYMS | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA2 | RET | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA2 | ABL1 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA2 | CDK6 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA2 | WEE1 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA2 | LCK | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA2 | KIT | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA2 | BTK | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA2 | SMO | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA2 | ERBB4 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA2 | MAPK1 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA2 | MAP2K1 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA2 | FGFR2 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA2 | AKT2 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA2 | NR4A3 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA2 | EPHA5 | 3 | |||||||
| afatinib | BRCA2 | ERBB4 | 3 | |||||||
| biospecimen collection, computed tomography, echocardiography, ipilimumab, magnetic resonance imaging, nivolumab | BRCA2 | CTLA4 | 3 | |||||||
| capecitabine, cisplatin | BRCA2 | TYMS | 3 | |||||||
| dec-205/ny-eso-1 fusion protein cdx-1401, laboratory biomarker analysis, pharmacological study, sirolimus | BRCA2 | MTOR | 3 | |||||||
| futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan | BRCA2 | TOP1 | 3 | |||||||
| futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan | BRCA2 | FGFR2 | 3 | |||||||
| gemcitabine | BRCA2 | TYMS | 3 | |||||||
| lurbinectedin, irinotecan | BRCA2 | TOP1 | 3 | |||||||
| mrtx849, pembrolizumab, cetuximab, afatinib | BRCA2 | ERBB4 | 3 | |||||||
| nivolumab or pembrolizumab (dependent upon approved indication), metformin, rosiglitazone | BRCA2 | RXRB | 3 | |||||||
| pembrolizumab, belzutifan, lenvatinib | BRCA2 | RET | 3 | |||||||
| pembrolizumab, belzutifan, lenvatinib | BRCA2 | KIT | 3 | |||||||
| pembrolizumab, belzutifan, lenvatinib | BRCA2 | FGFR2 | 3 | |||||||
| srf617, gemcitabine, albumin-bound paclitaxel, pembrolizumab | BRCA2 | TYMS | 3 | |||||||
| abemaciclib | BRCA2 | CDK6 | 7 | |||||||
| avapritinib | BRCA2 | KIT | 7 | |||||||
| capecitabine | BRCA2 | TYMS | 7 | |||||||
| everolimus | BRCA2 | MTOR | 7 | |||||||
| ibrutinib | BRCA2 | BTK | 7 | |||||||
| nintedanib | BRCA2 | FGFR2 | 7 | |||||||
| palbociclib | BRCA2 | CDK6 | 7 | |||||||
| pazopanib | BRCA2 | KIT | 7 | |||||||
| regorafenib | BRCA2 | RET | 7 | |||||||
| regorafenib | BRCA2 | ABL1 | 7 | |||||||
| regorafenib | BRCA2 | KIT | 7 | |||||||
| regorafenib | BRCA2 | FGFR2 | 7 | |||||||
| sacituzumab govitecan | BRCA2 | TOP1 | 7 | |||||||
| topotecan | BRCA2 | TOP1 | 7 | |||||||
| trastuzumab deruxtecan | BRCA2 | TOP1 | 5 | |||||||
| 5-fu, atezolizumab, bevacizumab, gemcitabine, leucovorin, nab-paclitaxel, oxaliplatin, capecitabine, cisplatin | BRCA2 | TYMS | 2 | |||||||
| ab598, zimberelimab, fluorouracil, leucovorin, oxaliplatin | BRCA2 | TYMS | 2 | |||||||
| adavosertib, radiation therapy | BRCA2 | WEE1 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | BRCA2 | RET | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | BRCA2 | ABL1 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | BRCA2 | IGF1R | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | BRCA2 | ERBB4 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | BRCA2 | FLT3 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | BRCA2 | TYMS | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | BRCA2 | MAP2K1 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | BRCA2 | FGFR2 | 2 | |||||||
| alvocidib, paclitaxel | BRCA2 | CDK9 | 2 | |||||||
| alvocidib, paclitaxel | BRCA2 | CDK6 | 2 | |||||||
| apatinib, irinotecan | BRCA2 | TOP1 | 2 | |||||||
| asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan | BRCA2 | TOP1 | 2 | |||||||
| asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan | BRCA2 | TYMS | 2 | |||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | BRCA2 | TOP1 | 2 | |||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | BRCA2 | TYMS | 2 | |||||||
| avelumab, lorlatanib, talazoparib, pemetrexed, axitinib, cmp 001, utomilumab, pf04518600 | BRCA2 | TYMS | 2 | |||||||
| bbi-355, erlotinib, futibatinib | BRCA2 | FGFR2 | 2 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | BRCA2 | ABL1 | 2 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | BRCA2 | LCK | 2 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | BRCA2 | KIT | 2 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | BRCA2 | BTK | 2 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | BRCA2 | TYMS | 2 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | BRCA2 | NR4A3 | 2 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | BRCA2 | EPHA5 | 2 | |||||||
| bevacizumab, oxaliplatin, leucovorin calcium, fluorouracil, therapeutic conventional surgery, laboratory biomarker analysis | BRCA2 | TYMS | 2 | |||||||
| binimetinib, biopsy, biospecimen collection, bone scan, computed tomography, magnetic resonance imaging, palbociclib | BRCA2 | CDK6 | 2 | |||||||
| binimetinib, biopsy, biospecimen collection, bone scan, computed tomography, magnetic resonance imaging, palbociclib | BRCA2 | MAP2K1 | 2 | |||||||
| biospecimen collection, computed tomography, devimistat, fluorouracil, gemcitabine hydrochloride, hydroxychloroquine, magnetic resonance imaging | BRCA2 | TYMS | 2 | |||||||
| biospecimen collection, computed tomography, pemetrexed | BRCA2 | TYMS | 2 | |||||||
| bms-986207, nivolumab, ipilimumab | BRCA2 | CTLA4 | 2 | |||||||
| bortezomib | BRCA2 | PSMB5 | 2 | |||||||
| cabozantinib | BRCA2 | RET | 2 | |||||||
| cabozantinib, atezolizumab, cabozantinib, cabozantinib | BRCA2 | RET | 2 | |||||||
| capecitabine, carboplatin, epirubicin hydrochloride | BRCA2 | TYMS | 2 | |||||||
| capecitabine, docetaxel | BRCA2 | TYMS | 2 | |||||||
| capecitabine, irinotecan hydrochloride | BRCA2 | TYMS | 2 | |||||||
| capecitabine, oxaliplatin | BRCA2 | TYMS | 2 | |||||||
| capecitabine, oxaliplatin, gene expression analysis, microarray analysis, reverse transcriptase-polymerase chain reaction, adjuvant therapy, biopsy, conventional surgery, neoadjuvant therapy, quality-of-life assessment, radiation therapy | BRCA2 | TYMS | 2 | |||||||
| capecitabine, temozolomide | BRCA2 | TYMS | 2 | |||||||
| carboplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy | BRCA2 | TYMS | 2 | |||||||
| cetuximab, cisplatin, fluorouracil, conventional surgery | BRCA2 | TYMS | 2 | |||||||
| cetuximab, cisplatin, irinotecan, radiation therapy, surgery | BRCA2 | TOP1 | 2 | |||||||
| cft1946, trametinib, cetuximab | BRCA2 | MAP2K1 | 2 | |||||||
| chemotherapy, cisplatin, fluorouracil, low-let electron therapy, low-let photon therapy | BRCA2 | TYMS | 2 | |||||||
| cisplatin, fluorouracil, conventional surgery, neoadjuvant therapy, radiation therapy | BRCA2 | TYMS | 2 | |||||||
| cisplatin, fluorouracil, iressa, conventional surgery, radiation therapy | BRCA2 | TYMS | 2 | |||||||
| cisplatin, fluorouracil, paclitaxel, conventional surgery, neoadjuvant therapy, radiation therapy | BRCA2 | TYMS | 2 | |||||||
| cisplatin, fluorouracil, paclitaxel, surgical procedure, radiation therapy | BRCA2 | TYMS | 2 | |||||||
| cisplatin, fluorouracil, surgical procedure, radiation therapy | BRCA2 | TYMS | 2 | |||||||
| cisplatin, pemetrexed, gemcitabine, carboplatin, certolizumab, nivolumab | BRCA2 | TYMS | 2 | |||||||
| cixutumumab, everolimus, laboratory biomarker analysis, octreotide acetate, pharmacological study | BRCA2 | IGF1R | 2 | |||||||
| cixutumumab, everolimus, laboratory biomarker analysis, octreotide acetate, pharmacological study | BRCA2 | MTOR | 2 | |||||||
| cixutumumab, laboratory biomarker analysis, paclitaxel, pharmacological study | BRCA2 | IGF1R | 2 | |||||||
| cobimetinib, mehd7945a | BRCA2 | MAP2K1 | 2 | |||||||
| durvalumab, tremelimumab, oxaliplatin, capecitabine, radiotherapy, paclitaxel, carboplatin, 5-fluorouracil (5-fu), leucovorin, docetaxel | BRCA2 | CTLA4 | 2 | |||||||
| durvalumab, tremelimumab, oxaliplatin, capecitabine, radiotherapy, paclitaxel, carboplatin, 5-fluorouracil (5-fu), leucovorin, docetaxel | BRCA2 | TYMS | 2 | |||||||
| durvalumab, tremelimumab, sbrt | BRCA2 | CTLA4 | 2 | |||||||
| eft226, sotorasib, fulvestrant, abemaciclib, trastuzumab | BRCA2 | CDK6 | 2 | |||||||
| entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib | BRCA2 | RET | 2 | |||||||
| entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib | BRCA2 | FLT3 | 2 | |||||||
| entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib | BRCA2 | FGFR2 | 2 | |||||||
| erlotinib hydrochloride, oxaliplatin, fluorouracil, radiation therapy, conventional surgery, immunohistochemistry staining method, positron emission tomography, computed tomography, laboratory biomarker analysis, gene expression analysis, fludeoxyglucose f 18 | BRCA2 | TYMS | 2 | |||||||
| filgrastim, cisplatin, fluorouracil, paclitaxel, radiation therapy | BRCA2 | TYMS | 2 | |||||||
| filgrastim, pegfilgrastim, cisplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy | BRCA2 | TYMS | 2 | |||||||
| fluorouracil, gemcitabine hydrochloride, leucovorin calcium | BRCA2 | TYMS | 2 | |||||||
| fluorouracil, irinotecan hydrochloride, leucovorin calcium, pharmacogenomic studies, pharmacological study | BRCA2 | TYMS | 2 | |||||||
| fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study | BRCA2 | HDAC3 | 2 | |||||||
| fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study | BRCA2 | HDAC6 | 2 | |||||||
| fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study | BRCA2 | HDAC2 | 2 | |||||||
| fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study | BRCA2 | TYMS | 2 | |||||||
| fluorouracil, oxaliplatin, conventional surgery, radiation therapy | BRCA2 | TYMS | 2 | |||||||
| gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a | BRCA2 | RET | 2 | |||||||
| gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a | BRCA2 | KIT | 2 | |||||||
| gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a | BRCA2 | FGFR2 | 2 | |||||||
| inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide | BRCA2 | TOP1 | 2 | |||||||
| inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide | BRCA2 | TYMS | 2 | |||||||
| ioa-244, avelumab injection, pemetrexed, cisplatin, ruxolitinib | BRCA2 | TYK2 | 2 | |||||||
| ioa-244, avelumab injection, pemetrexed, cisplatin, ruxolitinib | BRCA2 | TYMS | 2 | |||||||
| ipilimumab | BRCA2 | CTLA4 | 2 | |||||||
| irinotecan, capecitabine | BRCA2 | TOP1 | 2 | |||||||
| irinotecan, capecitabine | BRCA2 | TYMS | 2 | |||||||
| irinotecan, docetaxel | BRCA2 | TOP1 | 2 | |||||||
| jab-3312, binimetinib, pembrolizumab, sotorasib, osimertinib | BRCA2 | MAP2K1 | 2 | |||||||
| ksq-001ex, interleukin-2, cyclophosphamide, fludarabine | BRCA2 | DCK | 2 | |||||||
| laboratory biomarker analysis, oxaliplatin, pralatrexate | BRCA2 | TYMS | 2 | |||||||
| lenvatinib, pembrolizumab | BRCA2 | RET | 2 | |||||||
| lenvatinib, pembrolizumab | BRCA2 | KIT | 2 | |||||||
| lenvatinib, pembrolizumab | BRCA2 | FGFR2 | 2 | |||||||
| lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate | BRCA2 | RET | 2 | |||||||
| lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate | BRCA2 | KIT | 2 | |||||||
| lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate | BRCA2 | FGFR2 | 2 | |||||||
| ly3022855, durvalumab, tremelimumab | BRCA2 | CTLA4 | 2 | |||||||
| ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab | BRCA2 | TOP1 | 2 | |||||||
| ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab | BRCA2 | TYMS | 2 | |||||||
| m6620, cisplatin, capecitabine, radiotherapy | BRCA2 | TYMS | 2 | |||||||
| mirdametinib, bgb-3245 | BRCA2 | MAP2K1 | 2 | |||||||
| mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed | BRCA2 | TYMS | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | BRCA2 | RET | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | BRCA2 | KIT | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | BRCA2 | TYMS | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | BRCA2 | FGFR2 | 2 | |||||||
| nab-paclitaxel, gemcitabine | BRCA2 | TYMS | 2 | |||||||
| nintedanib | BRCA2 | LCK | 2 | |||||||
| nintedanib | BRCA2 | FLT3 | 2 | |||||||
| nintedanib, pembrolizumab | BRCA2 | LCK | 2 | |||||||
| nintedanib, pembrolizumab | BRCA2 | FLT3 | 2 | |||||||
| nintedanib, pembrolizumab | BRCA2 | FGFR2 | 2 | |||||||
| nivolumab, ipilimumab, cobimetinib | BRCA2 | CTLA4 | 2 | |||||||
| nivolumab, ipilimumab, cobimetinib | BRCA2 | MAP2K1 | 2 | |||||||
| ociperlimab, tislelizumab, pemetrexed, paclitaxel, nab paclitaxel, carboplatin, cisplatin, etoposide, 5fluorouracil, oxaliplatin, capecitabine | BRCA2 | TOP2A | 2 | |||||||
| ociperlimab, tislelizumab, pemetrexed, paclitaxel, nab paclitaxel, carboplatin, cisplatin, etoposide, 5fluorouracil, oxaliplatin, capecitabine | BRCA2 | TYMS | 2 | |||||||
| oleclumab, durvalumab, gemcitabine, nab-paclitaxel, oxaliplatin, folinic acid, 5-fu | BRCA2 | TYMS | 2 | |||||||
| oxaliplatin, irinotecan hydrochloride, leucovorin calcium, fluorouracil, laboratory biomarker analysis | BRCA2 | TYMS | 2 | |||||||
| pembrolizumab, guadecitabine, mocetinostat | BRCA2 | HDAC3 | 2 | |||||||
| pembrolizumab, guadecitabine, mocetinostat | BRCA2 | HDAC2 | 2 | |||||||
| pembrolizumab, lenvatinib | BRCA2 | RET | 2 | |||||||
| pembrolizumab, lenvatinib | BRCA2 | KIT | 2 | |||||||
| pembrolizumab, lenvatinib | BRCA2 | FGFR2 | 2 | |||||||
| pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu | BRCA2 | RET | 2 | |||||||
| pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu | BRCA2 | KIT | 2 | |||||||
| pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu | BRCA2 | TYMS | 2 | |||||||
| pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu | BRCA2 | FGFR2 | 2 | |||||||
| pembrolizumab, paclitaxel, docetaxel, irinotecan | BRCA2 | TOP1 | 2 | |||||||
| pembrolizumab, sonidegib | BRCA2 | SMO | 2 | |||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | BRCA2 | RET | 2 | |||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | BRCA2 | KIT | 2 | |||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | BRCA2 | TYMS | 2 | |||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | BRCA2 | FGFR2 | 2 | |||||||
| pemetrexed, bevacizumab | BRCA2 | TYMS | 2 | |||||||
| pharmacological study, romidepsin | BRCA2 | ABCC1 | 2 | |||||||
| pharmacological study, romidepsin | BRCA2 | HDAC4 | 2 | |||||||
| pharmacological study, romidepsin | BRCA2 | HDAC6 | 2 | |||||||
| pharmacological study, romidepsin | BRCA2 | HDAC2 | 2 | |||||||
| pralatrexate, docetaxel, fludeoxyglucose f 18, positron emission tomography | BRCA2 | TYMS | 2 | |||||||
| quality-of-life assessment, questionnaire administration, selpercatinib, therapeutic conventional surgery | BRCA2 | RET | 2 | |||||||
| quality-of-life assessment, questionnaire administration, selpercatinib, therapeutic conventional surgery | BRCA2 | FGFR2 | 2 | |||||||
| regorafenib, laboratory biomarker analysis | BRCA2 | RET | 2 |