Drugs that target a gene either directly (oncogene) or via a synthetic-lethal partner (SLP) of a mutated tumour suppressor (TSG). Cell colour shows the strongest known status of that drug for that cancer subtype: approved clinical trial repositionable (potential reuse, no evidence yet) or blank.
| Drug | TSG | SLP (drug target) | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | # |
|---|---|---|---|---|---|---|---|---|---|---|
| olaparib | BRCA1 | PARP1 | 1 | |||||||
| olaparib | BRCA1 | PARP2 | 1 | |||||||
| sunitinib | BRCA1 | PDGFRA | 7 | |||||||
| sunitinib | BRCA1 | FLT3 | 7 | |||||||
| sunitinib | BRCA1 | KDR | 7 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | BRCA1 | PDGFRA | 4 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | BRCA1 | VEGFA | 4 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | BRCA1 | KDR | 4 | |||||||
| regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) | BRCA1 | PDGFRA | 4 | |||||||
| regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) | BRCA1 | KDR | 4 | |||||||
| gemcitabine | BRCA1 | RRM1 | 7 | |||||||
| ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine | BRCA1 | VEGFA | 3 | |||||||
| ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine | BRCA1 | RRM1 | 3 | |||||||
| ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine | BRCA1 | KDR | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA1 | WEE1 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA1 | PDGFRA | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA1 | CDK6 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA1 | KDR | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA1 | CDK4 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA1 | PIK3CA | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | BRCA1 | PIK3CB | 3 | |||||||
| bevacizumab | BRCA1 | VEGFA | 3 | |||||||
| dec-205/ny-eso-1 fusion protein cdx-1401, laboratory biomarker analysis, pharmacological study, sirolimus | BRCA1 | MTOR | 3 | |||||||
| futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan | BRCA1 | TOP1 | 3 | |||||||
| lurbinectedin, irinotecan | BRCA1 | TOP1 | 3 | |||||||
| pembrolizumab, belzutifan, lenvatinib | BRCA1 | PDGFRA | 3 | |||||||
| pembrolizumab, belzutifan, lenvatinib | BRCA1 | KDR | 3 | |||||||
| srf617, gemcitabine, albumin-bound paclitaxel, pembrolizumab | BRCA1 | RRM1 | 3 | |||||||
| abemaciclib | BRCA1 | CDK6 | 7 | |||||||
| abemaciclib | BRCA1 | CDK4 | 7 | |||||||
| cabozantinib | BRCA1 | KDR | 7 | |||||||
| everolimus | BRCA1 | MTOR | 7 | |||||||
| nintedanib | BRCA1 | PDGFRA | 7 | |||||||
| nintedanib | BRCA1 | KDR | 7 | |||||||
| palbociclib | BRCA1 | CDK6 | 7 | |||||||
| palbociclib | BRCA1 | CDK4 | 7 | |||||||
| pazopanib | BRCA1 | PDGFRA | 7 | |||||||
| pazopanib | BRCA1 | KDR | 7 | |||||||
| regorafenib | BRCA1 | PDGFRA | 7 | |||||||
| regorafenib | BRCA1 | KDR | 7 | |||||||
| sacituzumab govitecan | BRCA1 | TOP1 | 7 | |||||||
| topotecan | BRCA1 | TOP1 | 7 | |||||||
| trastuzumab deruxtecan | BRCA1 | TOP1 | 5 | |||||||
| ramucirumab | BRCA1 | KDR | 3 | |||||||
| 5-fu, atezolizumab, bevacizumab, gemcitabine, leucovorin, nab-paclitaxel, oxaliplatin, capecitabine, cisplatin | BRCA1 | VEGFA | 2 | |||||||
| 5-fu, atezolizumab, bevacizumab, gemcitabine, leucovorin, nab-paclitaxel, oxaliplatin, capecitabine, cisplatin | BRCA1 | RRM1 | 2 | |||||||
| 5fu, nab-paclitaxel, bevacizumab, calcium leucovorin, oxaliplatin | BRCA1 | VEGFA | 2 | |||||||
| adavosertib, radiation therapy | BRCA1 | WEE1 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | BRCA1 | FLT3 | 2 | |||||||
| alvocidib, paclitaxel | BRCA1 | CDK6 | 2 | |||||||
| alvocidib, paclitaxel | BRCA1 | CDK2 | 2 | |||||||
| alvocidib, paclitaxel | BRCA1 | CDK4 | 2 | |||||||
| alvocidib, paclitaxel | BRCA1 | CDK5 | 2 | |||||||
| antineoplastic vaccine, sargramostim, pembrolizumab | BRCA1 | SDC2 | 2 | |||||||
| apatinib, irinotecan | BRCA1 | TOP1 | 2 | |||||||
| asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan | BRCA1 | TOP1 | 2 | |||||||
| asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan | BRCA1 | KDR | 2 | |||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | BRCA1 | TOP1 | 2 | |||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | BRCA1 | RRM1 | 2 | |||||||
| avelumab, lorlatanib, talazoparib, pemetrexed, axitinib, cmp 001, utomilumab, pf04518600 | BRCA1 | KDR | 2 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | BRCA1 | VEGFA | 2 | |||||||
| bevacizumab, oxaliplatin, leucovorin calcium, fluorouracil, therapeutic conventional surgery, laboratory biomarker analysis | BRCA1 | VEGFA | 2 | |||||||
| binimetinib, biopsy, biospecimen collection, bone scan, computed tomography, magnetic resonance imaging, palbociclib | BRCA1 | CDK6 | 2 | |||||||
| binimetinib, biopsy, biospecimen collection, bone scan, computed tomography, magnetic resonance imaging, palbociclib | BRCA1 | CDK4 | 2 | |||||||
| bryostatin 1, paclitaxel | BRCA1 | CASP8 | 2 | |||||||
| cabozantinib, atezolizumab, cabozantinib, cabozantinib | BRCA1 | KDR | 2 | |||||||
| carboplatin, celecoxib, paclitaxel, adjuvant therapy, conventional surgery, neoadjuvant therapy | BRCA1 | CA3 | 2 | |||||||
| cetuximab, cisplatin, irinotecan, radiation therapy, surgery | BRCA1 | TOP1 | 2 | |||||||
| cisplatin, pemetrexed, gemcitabine, carboplatin, certolizumab, nivolumab | BRCA1 | RRM1 | 2 | |||||||
| cixutumumab, everolimus, laboratory biomarker analysis, octreotide acetate, pharmacological study | BRCA1 | MTOR | 2 | |||||||
| cpt- 11, cisplatin, celecoxib, radiation, surgery | BRCA1 | CA3 | 2 | |||||||
| cyclophosphamide, neoantigen peptide vaccine, pembrolizumab, sargramostim | BRCA1 | SDC2 | 2 | |||||||
| eft226, sotorasib, fulvestrant, abemaciclib, trastuzumab | BRCA1 | CDK6 | 2 | |||||||
| eft226, sotorasib, fulvestrant, abemaciclib, trastuzumab | BRCA1 | CDK4 | 2 | |||||||
| entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib | BRCA1 | FLT3 | 2 | |||||||
| entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib | BRCA1 | KDR | 2 | |||||||
| fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study | BRCA1 | HDAC2 | 2 | |||||||
| gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a | BRCA1 | PDGFRA | 2 | |||||||
| gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a | BRCA1 | KDR | 2 | |||||||
| inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide | BRCA1 | TOP1 | 2 | |||||||
| irinotecan, capecitabine | BRCA1 | TOP1 | 2 | |||||||
| irinotecan, docetaxel | BRCA1 | TOP1 | 2 | |||||||
| ksq-001ex, interleukin-2, cyclophosphamide, fludarabine | BRCA1 | RRM1 | 2 | |||||||
| lenvatinib, pembrolizumab | BRCA1 | PDGFRA | 2 | |||||||
| lenvatinib, pembrolizumab | BRCA1 | KDR | 2 | |||||||
| lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate | BRCA1 | PDGFRA | 2 | |||||||
| lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate | BRCA1 | KDR | 2 | |||||||
| ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab | BRCA1 | TOP1 | 2 | |||||||
| ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab | BRCA1 | RRM1 | 2 | |||||||
| melphalan, bcnu, vitamin b12b, vitamin c, ethanol, autologous hematopoietic stem cells | BRCA1 | HTR3C | 2 | |||||||
| mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed | BRCA1 | RRM1 | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | BRCA1 | PDGFRA | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | BRCA1 | KDR | 2 | |||||||
| nab-paclitaxel, gemcitabine | BRCA1 | RRM1 | 2 | |||||||
| nintedanib | BRCA1 | FLT3 | 2 | |||||||
| nintedanib, pembrolizumab | BRCA1 | PDGFRA | 2 | |||||||
| nintedanib, pembrolizumab | BRCA1 | FLT3 | 2 | |||||||
| nintedanib, pembrolizumab | BRCA1 | KDR | 2 | |||||||
| olaparib | BRCA1 | PARP3 | 2 | |||||||
| oleclumab, durvalumab, gemcitabine, nab-paclitaxel, oxaliplatin, folinic acid, 5-fu | BRCA1 | RRM1 | 2 | |||||||
| osimertinib, bevacizumab, osimertinib | BRCA1 | VEGFA | 2 | |||||||
| pd-1 inhibitor, bevacizumab, carboplatin, cisplatin, pemtrexed | BRCA1 | VEGFA | 2 | |||||||
| pembrolizumab, guadecitabine, mocetinostat | BRCA1 | HDAC2 | 2 | |||||||
| pembrolizumab, lenvatinib | BRCA1 | PDGFRA | 2 | |||||||
| pembrolizumab, lenvatinib | BRCA1 | KDR | 2 | |||||||
| pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu | BRCA1 | PDGFRA | 2 | |||||||
| pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu | BRCA1 | KDR | 2 | |||||||
| pembrolizumab, paclitaxel, docetaxel, irinotecan | BRCA1 | TOP1 | 2 | |||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | BRCA1 | PDGFRA | 2 | |||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | BRCA1 | VEGFA | 2 | |||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | BRCA1 | RRM1 | 2 | |||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | BRCA1 | KDR | 2 | |||||||
| pemetrexed, bevacizumab | BRCA1 | VEGFA | 2 | |||||||
| pharmacological study, romidepsin | BRCA1 | HDAC2 | 2 | |||||||
| ramucirumab, paclitaxel | BRCA1 | KDR | 2 | |||||||
| regorafenib, laboratory biomarker analysis | BRCA1 | PDGFRA | 2 | |||||||
| regorafenib, laboratory biomarker analysis | BRCA1 | KDR | 2 | |||||||
| rubitecan | BRCA1 | TOP1 | 2 | |||||||
| sorafenib, administered orally, ct/mri | BRCA1 | FLT3 | 2 | |||||||
| sorafenib, administered orally, ct/mri | BRCA1 | KDR | 2 | |||||||
| sy-5609, fulvestrant, gemcitabine, nab-paclitaxel | BRCA1 | RRM1 | 2 | |||||||
| temsirolimus | BRCA1 | MTOR | 2 | |||||||
| temsirolimus, laboratory biomarker analysis | BRCA1 | MTOR | 2 | |||||||
| trastuzumab, abt-806, bemarituzumab, ramucirumab, nivolumab, standard cytotherapy | BRCA1 | KDR | 2 | |||||||
| tucidinostat (chidamide), pd-1 inhibitor (toripalimab), bevacizumab | BRCA1 | VEGFA | 2 | |||||||
| axitinib | BRCA1 | KDR | 7 | |||||||
| ribociclib | BRCA1 | CDK6 | 7 | |||||||
| ribociclib | BRCA1 | CDK4 | 7 | |||||||
| romidepsin | BRCA1 | HDAC2 | 7 | |||||||
| sorafenib | BRCA1 | FLT3 | 7 | |||||||
| sorafenib | BRCA1 | KDR | 7 | |||||||
| trilaciclib | BRCA1 | CDK6 | 7 | |||||||
| trilaciclib | BRCA1 | CDK4 | 7 | |||||||
| 18f-fluoromisonidazole, cediranib maleate, laboratory biomarker analysis, olaparib, positron emission tomography | BRCA1 | PARP3 | 1 | |||||||
| 3-dimensional conformal radiation therapy, bevacizumab, cisplatin, fluorouracil, intensity-modulated radiation therapy | BRCA1 | VEGFA | 1 | |||||||
| 3-dimensional conformal radiation therapy, bevacizumab, intensity-modulated radiation therapy, laboratory biomarker analysis, placebo, quality-of-life assessment, temozolomide | BRCA1 | VEGFA | 1 | |||||||
| 3-dimensional conformal radiation therapy, cognitive assessment, laboratory biomarker analysis, temozolomide, vorinostat | BRCA1 | HDAC2 | 1 | |||||||
| 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, vorinostat | BRCA1 | HDAC2 | 1 | |||||||
| 5 fluorouracil, leucovorin, irinotecan, oxaliplatin | BRCA1 | TOP1 | 1 | |||||||
| 5-fluorouracil (5-fu), leucovorin, oxaliplatin, atezolizumab, cobimetinib, ramucirumab, paclitaxel, pegylated recombinant human hyaluronidase (pegph20), bl-8040, linagliptin, atezolizumab, cobimetinib, cisplatin, tiragolumab, 5-fluorouracil (5-fu) | BRCA1 | KDR | 1 | |||||||
| 9-ing-41, gemcitabine - 21 day cycle, doxorubicin., lomustine, carboplatin., nab paclitaxel., paclitaxel., gemcitabine - 28 day cycle, irinotecan | BRCA1 | TOP1 | 1 | |||||||
| 9-ing-41, retifanlimab, gemcitabine, abraxane | BRCA1 | RRM1 | 1 | |||||||
| abemaciclib, abemaciclib | BRCA1 | CDK6 | 1 | |||||||
| abemaciclib, abemaciclib | BRCA1 | CDK4 | 1 | |||||||
| abemaciclib, bevacizumab | BRCA1 | VEGFA | 1 | |||||||
| abemaciclib, bevacizumab | BRCA1 | CDK6 | 1 | |||||||
| abemaciclib, bevacizumab | BRCA1 | CDK4 | 1 | |||||||
| abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf | BRCA1 | TOP1 | 1 | |||||||
| abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf | BRCA1 | CDK6 | 1 | |||||||
| abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf | BRCA1 | CDK4 | 1 | |||||||
| abemaciclib, ly3023414, gemcitabine, capecitabine | BRCA1 | CDK6 | 1 | |||||||
| abemaciclib, ly3023414, gemcitabine, capecitabine | BRCA1 | RRM1 | 1 | |||||||
| abemaciclib, ly3023414, gemcitabine, capecitabine | BRCA1 | CDK4 | 1 | |||||||
| abemaciclib, ly3214996 | BRCA1 | CDK6 | 1 | |||||||
| abemaciclib, ly3214996 | BRCA1 | CDK4 | 1 | |||||||
| abemaciclib, surgery | BRCA1 | CDK6 | 1 | |||||||
| abemaciclib, surgery | BRCA1 | CDK4 | 1 | |||||||
| abraxane (nab-paclitaxel), gemcitabine | BRCA1 | RRM1 | 1 | |||||||
| acetazolamide, temozolomide | BRCA1 | CA3 | 1 | |||||||
| acetazolamide, temozolomide | BRCA1 | CA1 | 1 | |||||||
| adavosertib | BRCA1 | WEE1 | 1 | |||||||
| adavosertib, laboratory biomarker analysis, pharmacological study, radiation therapy | BRCA1 | WEE1 | 1 | |||||||
| adavosertib, radiation therapy, temozolomide | BRCA1 | WEE1 | 1 | |||||||
| adct-601, gemcitabine | BRCA1 | RRM1 | 1 | |||||||
| adjuvant therapy, temozolomide, valproic acid, radiation therapy | BRCA1 | HDAC2 | 1 | |||||||
| adriamycin, cyclophosphamide, vindesine, valproic acid | BRCA1 | HDAC2 | 1 | |||||||
| aee788, everolimus | BRCA1 | MTOR | 1 | |||||||
| aerosol sargramostim, sargramostim, cisplatin, doxorubicin hydrochloride, ifosfamide, mitomycin c, flow cytometry, immunological diagnostic method, laboratory biomarker analysis, adjuvant therapy, multimodality therapy, neoadjuvant therapy, therapeutic conventional surgery, intraoperative radiation therapy, selective external radiation therapy | BRCA1 | SDC2 | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | BRCA1 | PARP3 | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | BRCA1 | CDK6 | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | BRCA1 | MTOR | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | BRCA1 | CDK4 | 1 | |||||||
| afatinib, irinotecan | BRCA1 | TOP1 | 1 | |||||||
| ag-013736, gemcitabine, gemcitabine, placebo | BRCA1 | RRM1 | 1 | |||||||
| agen1423, botensilimab, gemcitabine, nab-paclitaxel | BRCA1 | RRM1 | 1 | |||||||
| agent-797, botensilimab, balstilimab, ramucirumab, paclitaxel | BRCA1 | KDR | 1 | |||||||
| ags-1c4d4, gemcitabine | BRCA1 | RRM1 | 1 | |||||||
| ak104, ak104, gemcitabine, nab-paclitaxel | BRCA1 | RRM1 | 1 | |||||||
| ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, nab-paclitaxel, gemcitabine, nab-paclitaxel, gemcitabine | BRCA1 | RRM1 | 1 | |||||||
| albumin-bound paclitaxel (abi-007), gemcitabine | BRCA1 | RRM1 | 1 | |||||||
| aldesleukin, antibody therapy, fluorouracil, gemcitabine hydrochloride, irinotecan hydrochloride, laboratory biomarker analysis, leucovorin calcium, oxaliplatin, paclitaxel albumin-stabilized nanoparticle formulation, sargramostim | BRCA1 | SDC2 | 1 | |||||||
| aldesleukin, autologous tumor cell vaccine, filgrastim, sargramostim, therapeutic autologous lymphocytes, carmustine, cisplatin, cyclophosphamide, paclitaxel, autologous bone marrow transplantation, conventional surgery, peripheral blood stem cell transplantation | BRCA1 | SDC2 | 1 | |||||||
| aldesleukin, autologous tumor cell vaccine, muromonab-cd3, sargramostim, therapeutic autologous lymphocytes, surgical procedure, radiation therapy | BRCA1 | SDC2 | 1 | |||||||
| aldesleukin, biopsy, biospecimen collection, computed tomography, cyclophosphamide, excisional biopsy, fludarabine, magnetic resonance imaging, standard treatment, therapeutic tumor infiltrating lymphocytes | BRCA1 | RRM1 | 1 | |||||||
| aldoxorubicin, topotecan | BRCA1 | TOP1 | 1 | |||||||
| alisertib | BRCA1 | AURKA | 1 | |||||||
| alisertib, gemcitabine | BRCA1 | RRM1 | 1 | |||||||
| alisertib, gemcitabine | BRCA1 | AURKA | 1 | |||||||
| allogeneic tumor cell vaccine, recombinant interferon alfa, sargramostim, cyclophosphamide | BRCA1 | SDC2 | 1 | |||||||
| alpelisib, everolimus, exemestane | BRCA1 | MTOR | 1 | |||||||
| alpelisib, everolimus, exemestane | BRCA1 | PIK3CA | 1 | |||||||
| alvocidib, docetaxel | BRCA1 | CDK6 | 1 | |||||||
| alvocidib, docetaxel | BRCA1 | CDK2 | 1 | |||||||
| alvocidib, docetaxel | BRCA1 | CDK4 | 1 | |||||||
| alvocidib, docetaxel | BRCA1 | CDK5 | 1 | |||||||
| alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis | BRCA1 | CDK6 | 1 | |||||||
| alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis | BRCA1 | CDK2 | 1 | |||||||
| alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis | BRCA1 | CDK4 | 1 | |||||||
| alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis | BRCA1 | CDK5 | 1 | |||||||
| amg 193, gemcitabine, nab-paclitaxel, modified folfirinox | BRCA1 | RRM1 | 1 |