Drug × Cancer matrix

Drugs that target a gene either directly (oncogene) or via a synthetic-lethal partner (SLP) of a mutated tumour suppressor (TSG). Cell colour shows the strongest known status of that drug for that cancer subtype: approved clinical trial repositionable (potential reuse, no evidence yet) or blank.

Cancer key
GBM — Glioblastoma (CNS astrocytoma grade IV) LUAD — Lung adenocarcinoma SCLC — Small cell lung carcinoma LUSC — Lung squamous cell carcinoma OAC — Oesophageal adenocarcinoma OSCC — Oesophageal squamous cell carcinoma PDAC — Pancreatic ductal adenocarcinoma
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Showing 200 of 337 drug-target rows in SSL view, for TSG = TBX3.
Drug TSG SLP (drug target) GBM LUAD SCLC LUSC OAC OSCC PDAC #
neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab TBX3 RET 4
regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) TBX3 RET 4
adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib TBX3 RET 3
futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan TBX3 TOP1MT 3
lurbinectedin, irinotecan TBX3 TOP1MT 3
nivolumab or pembrolizumab (dependent upon approved indication), metformin, rosiglitazone TBX3 RXRB 3
pembrolizumab, belzutifan, lenvatinib TBX3 RET 3
regorafenib TBX3 RET 7
alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel TBX3 RET 2
alvocidib, paclitaxel TBX3 CDK9 2
apatinib, irinotecan TBX3 TOP1MT 2
asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan TBX3 TOP1MT 2
asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine TBX3 TOP1MT 2
bortezomib TBX3 PSMB5 2
bryostatin 1, paclitaxel TBX3 PRKCE 2
cabozantinib TBX3 RET 2
cabozantinib, atezolizumab, cabozantinib, cabozantinib TBX3 RET 2
cetuximab, cisplatin, irinotecan, radiation therapy, surgery TBX3 TOP1MT 2
entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib TBX3 RET 2
fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study TBX3 HDAC3 2
gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a TBX3 RET 2
inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide TBX3 TOP1MT 2
irinotecan, capecitabine TBX3 TOP1MT 2
irinotecan, docetaxel TBX3 TOP1MT 2
lenvatinib, pembrolizumab TBX3 RET 2
lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate TBX3 RET 2
ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab TBX3 TOP1MT 2
mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a TBX3 RET 2
pembrolizumab, guadecitabine, mocetinostat TBX3 HDAC3 2
pembrolizumab, lenvatinib TBX3 RET 2
pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu TBX3 RET 2
pembrolizumab, paclitaxel, docetaxel, irinotecan TBX3 TOP1MT 2
pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin TBX3 RET 2
quality-of-life assessment, questionnaire administration, selpercatinib, therapeutic conventional surgery TBX3 RET 2
regorafenib, laboratory biomarker analysis TBX3 RET 2
sorafenib, administered orally, ct/mri TBX3 RET 2
topotecan TBX3 TOP1MT 2
carfilzomib TBX3 PSMB5 7
selpercatinib TBX3 RET 7
sorafenib TBX3 RET 7
vandetanib TBX3 RET 7
3-dimensional conformal radiation therapy, cognitive assessment, laboratory biomarker analysis, temozolomide, vorinostat TBX3 HDAC3 1
3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, vorinostat TBX3 HDAC3 1
5 fluorouracil, leucovorin, irinotecan, oxaliplatin TBX3 TOP1MT 1
9-ing-41, gemcitabine - 21 day cycle, doxorubicin., lomustine, carboplatin., nab paclitaxel., paclitaxel., gemcitabine - 28 day cycle, irinotecan TBX3 TOP1MT 1
abemaciclib, irinotecan, temozolomide, dinutuximab, gm-csf TBX3 TOP1MT 1
acetazolamide, temozolomide TBX3 CA14 1
actidose aqua, artesunate, amodiaquine TBX3 HNMT 1
afatinib, irinotecan TBX3 TOP1MT 1
aldoxorubicin, topotecan TBX3 TOP1MT 1
alvocidib, docetaxel TBX3 CDK9 1
alvocidib, gemcitabine hydrochloride, 3-dimensional conformal radiation therapy, laboratory biomarker analysis TBX3 CDK9 1
aminolevulinic acid TBX3 ALAD 1
aminolevulinic acid, surgical resection TBX3 ALAD 1
amrubicin, topotecan TBX3 TOP1MT 1
andecaliximab, gemcitabine, nab-paclitaxel, carboplatin, pemetrexed, leucovorin, oxaliplatin, 5-fu, bevacizumab, irinotecan, paclitaxel TBX3 TOP1MT 1
ascorbic acid, paclitaxel protein-bound, cisplatin, gemcitabine TBX3 EGLN3 1
at-101, topotecan TBX3 TOP1MT 1
atezolizumab, cabozantinib TBX3 RET 1
atorvastatin, temozolomide, radiotherapy TBX3 NR1I3 1
avastin, bortezomib TBX3 PSMB5 1
avastin, temozolomide, irinotecan TBX3 TOP1MT 1
avastin, temozolomide, radiation therapy (xrt), irinotecan TBX3 TOP1MT 1
avelumab, irinotecan, paclitaxel, best supportive care (bsc) TBX3 TOP1MT 1
azacitidine, vorinostat, gemcitabine, busulfan, melphalan, dexamethasone, caphosol, glutamine, pyridoxine, rituximab TBX3 HDAC3 1
azd0901, 5-fluorouracil, leucovorin, l-leucovorin, irinotecan, nanoliposomal irinotecan, gemcitabine TBX3 TOP1MT 1
bbi608, nab-paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, fluorouracil, mm-398 TBX3 TOP1MT 1
bemarituzumab, paclitaxel, ramucirumab, bemarituzumab, irinotecan, bemarituzumab, trifluridine/tipiracil TBX3 TOP1MT 1
berzosertib, computed tomography assisted biopsy, endoscopic biopsy, irinotecan, magnetic resonance imaging TBX3 TOP1MT 1
bevacizumab [avastin], irinotecan, temozolomide TBX3 TOP1MT 1
bevacizumab, irinotecan TBX3 TOP1MT 1
bevacizumab, irinotecan, dynamic contrast-enhanced magnetic resonance imaging TBX3 TOP1MT 1
bevacizumab, temozolomide, radiation therapy (xrt), topotecan TBX3 TOP1MT 1
bevacizumab, temozolomide, vorinostat TBX3 HDAC3 1
bi 764532, topotecan, single agent chemotherapy TBX3 TOP1MT 1
biopsy, biospecimen collection, computed tomography, endoscopic ultrasound, fluorouracil, irinotecan, leucovorin, lymph node biopsy, magnetic resonance imaging, oxaliplatin, pembrolizumab, photodynamic therapy, positron emission tomography, questionnaire administration, verteporfin TBX3 TOP1MT 1
biopsy, biospecimen collection, computed tomography, erdafitinib, magnetic resonance imaging TBX3 RET 1
biospecimen collection, computed tomography, core biopsy, fluorouracil, irinotecan, leucovorin, leucovorin calcium, oxaliplatin, quemliclustat, zimberelimab TBX3 TOP1MT 1
biospecimen collection, erdafitinib, magnetic resonance imaging, optical coherence tomography TBX3 RET 1
bl-b01d1, irinotecan, paclitaxel, docetaxel TBX3 TOP1MT 1
bl-b01d1, topotecan TBX3 TOP1MT 1
bnt327 dose level 1 (dl1), bnt327 dose level 2 (dl2), etoposide, carboplatin, paclitaxel, topotecan TBX3 TOP1MT 1
bortezomib, carboplatin, paclitaxel TBX3 PSMB5 1
bortezomib, gemcitabine hydrochloride TBX3 PSMB5 1
bortezomib, irinotecan TBX3 PSMB5 1
bortezomib, irinotecan TBX3 TOP1MT 1
bortezomib, radiation therapy TBX3 PSMB5 1
bortezomib, temozolomide, pharmacological study TBX3 PSMB5 1
cabozantinib, durvalumab, tremelimumab TBX3 RET 1
cabozantinib, nivolumab TBX3 RET 1
cabozantinib, pembrolizumab TBX3 RET 1
camrelizumab, docetaxel, irinotecan TBX3 TOP1MT 1
camrelizumab, irinotecan, paclitaxel, paclitaxel-albumin, docetaxel, anlotinib TBX3 TOP1MT 1
capecitabine, oxaliplatin, irinotecan TBX3 TOP1MT 1
capecitabine, vorinostat, radiotherapy, surgery to remove tumor TBX3 HDAC3 1
carboplatin, irinotecan TBX3 TOP1MT 1
carboxylesterase-expressing allogeneic neural stem cells, irinotecan, irinotecan hydrochloride, laboratory biomarker analysis, pharmacological study TBX3 TOP1MT 1
cetuximab, bevacizumab, irinotecan TBX3 TOP1MT 1
cetuximab, bortezomib TBX3 PSMB5 1
cetuximab, irinotecan, oxaliplatin, uft TBX3 TOP1MT 1
cisplatin, fluorouracil, gemcitabine, irinotecan, leucovorin, nab-paclitaxel, oxaliplatin, radiation therapy TBX3 TOP1MT 1
cisplatin, gleevec™, irinotecan TBX3 TOP1MT 1
cisplatin, irinotecan, capecitabine TBX3 TOP1MT 1
cisplatin, pemetrexed disodium, sorafenib TBX3 RET 1
digoxin, 5fluorouracil, calcium leucovorin, irinotecan, oxaliplatin TBX3 TOP1MT 1
durvalumab, oxaliplatin, irinotecan, calcium folinate (leucovorin), fluorouracil, pegylated g-csf TBX3 TOP1MT 1
eras-007, encorafenib, cetuximab, palbociclib TBX3 MAPK8 1
eras-007, encorafenib, cetuximab, palbociclib TBX3 LIMK2 1
erdafitinib TBX3 RET 1
etomidate, midazolam, meperidine TBX3 GRIN2B 1
everolimus, sorafenib TBX3 RET 1
fluorouracil, irinotecan, irinotecan hydrochloride, leucovorin, leucovorin calcium, nivolumab, oxaliplatin, therapeutic conventional surgery TBX3 TOP1MT 1
fluorouracil, leucovorin calcium, oxaliplatin, irinotecan, nivolumab, magnetic resonance imaging, computed tomography, biospecimen collection, questionnaire administration TBX3 TOP1MT 1
fluorouracil, oxaliplatin, irinotecan TBX3 TOP1MT 1
gemcitabine, erlotinib, sorafenib TBX3 RET 1
gemcitabine, nab-paclitaxel, irinotecan, intensity-modulated radiation therapy (imrt) TBX3 TOP1MT 1
gemcitabine, oxaliplatin, imatinib TBX3 RET 1
gemcitabine, placebo, sorafenib TBX3 RET 1
gemcitabine, sorafenib, radiotherapy TBX3 RET 1
gemcitabine, sorafenib, vorinostat, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, rosettesep, depfff TBX3 HDAC3 1
gemcitabine, sorafenib, vorinostat, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, rosettesep, depfff TBX3 RET 1
gemcitabine, taxotere, xeloda, cisplatin, irinotecan TBX3 TOP1MT 1
genistein, erlotinib hydrochloride, gemcitabine hydrochloride TBX3 ESRRA 1
h101, tislelizumab, lenvatinib TBX3 RET 1
ifinatamab deruxtecan, docetaxel, paclitaxel, irinotecan TBX3 TOP1MT 1
imatinib, irinotecan, carboplatin TBX3 TOP1MT 1
imatinib, irinotecan, carboplatin TBX3 RET 1
irinotecan hydrochloride liposome injection, topotecan TBX3 TOP1MT 1
irinotecan, 5-fluorouracil, leucovorin TBX3 TOP1MT 1
irinotecan, bevacizumab, fdopa-pet/mri imaging TBX3 TOP1MT 1
irinotecan, carboplatin, bevacizumab TBX3 TOP1MT 1
irinotecan, carboplatin, bevacizumab, radiation TBX3 TOP1MT 1
irinotecan, carboplatin, bevacizumab, radiation therapy TBX3 TOP1MT 1
irinotecan, cisplatin, simvastatin TBX3 TOP1MT 1
irinotecan, ibi343, paclitaxel TBX3 TOP1MT 1
irinotecan, leucovorin, 5-fluorouracil, docetaxel, cisplatin, leucovorin, 5-fluorouracil TBX3 TOP1MT 1
irinotecan, lurbinectedin, irinotecan, topotecan, lurbinectedin TBX3 TOP1MT 1
irinotecan, radiation therapy TBX3 TOP1MT 1
irinotecan, ramucirumab, blood for angiome profiling, blood for cfdna TBX3 TOP1MT 1
kc1036, irinotecan, docetaxel, s-1 TBX3 TOP1MT 1
ketoconazole TBX3 NR1I3 1
ko-2806, cabozantinib, adagrasib TBX3 RET 1
laboratory biomarker analysis, pharmacological study, temozolomide, vorinostat TBX3 HDAC3 1
lenalidomide, bevacizumab, sorafenib, temsirolimus, lenalidomide, oxaliplatin, leucovorin, 5-fluorouracil TBX3 RET 1
lenvatinib, bevacizumab TBX3 RET 1
liposomal irinotecan, 5-fu, lv, irinotecan TBX3 TOP1MT 1
ljm716, byl719, paclitaxel, docetaxel, irinotecan TBX3 TOP1MT 1
lurbinectedin, irinotecan, lurbinectedin, topotecan TBX3 TOP1MT 1
ly3962673, cetuximab, gemcitabine, nab-paclitaxel, oxaliplatin, leucovorin, irinotecan, 5-fluorouracil TBX3 TOP1MT 1
mebendazole, vincristine, carboplatin, temozolomide, bevacizumab, irinotecan TBX3 TOP1MT 1
nab-paclitaxel, gemcitabine, capecitabine, cisplatin, irinotecan, nab-paclitaxel, gemcitabine, capecitabine, cisplatin, irinotecan TBX3 TOP1MT 1
nab-paclitaxel, gemcitabine, cisplatin, irinotecan, capecitabine, pembrolizumab, olaparib TBX3 TOP1MT 1
nabiximols, temozolomide, nabiximols-matched placebo TBX3 CYP3A7 1
napabucasin, nab-paclitaxel, gemcitabine, nivolumab, paclitaxel, irinotecan, leucovorin, 5fluorouracil, bevacizumab TBX3 TOP1MT 1
nivolumab, cabozantinib TBX3 RET 1
np137, oxaliplatin, irinotecan, calcium levofolinate, 5 fu TBX3 TOP1MT 1
olaparib, temozolomide, irinotecan TBX3 TOP1MT 1
oxaliplatin, docetaxel, leucovorin, irinotecan, 5-fluorouracil TBX3 TOP1MT 1
oxaliplatin, irinotecan hydrochloride, leucovorin calcium, fluorouracil, ascorbic acid TBX3 EGLN3 1
oxaliplatin, irinotecan, 5-fu, gemcitabine, radiation therapy TBX3 TOP1MT 1
oxaliplatin, irinotecan, capecitabine TBX3 TOP1MT 1
oxaliplatin, irinotecan, folinic acid, 5-fluorouracil, gemcitabine, capecitabine TBX3 TOP1MT 1
oxaliplatin, irinotecan, leucovorin, 5-fluorouracil, capecitabine, radiation, surgery, gemcitabine TBX3 TOP1MT 1
oxaliplatin, irinotecan, leucovorin, fluorouracil, laboratory biomarker analysis, flow cytometry, immunohistochemistry staining method, pharmacological study, pf-04136309 TBX3 TOP1MT 1
oxaliplatin, sorafenib TBX3 RET 1
oxaliplatine, folinic acid, irinotecan, 5-fu TBX3 TOP1MT 1
paclitaxel, bryostatin 1 TBX3 PRKCE 1
paclitaxel, irinotecan, pembrolizumab, mk-4830, lenvatinib, sacituzumab tirumotecan, antihistamine, h2 receptor antagonist, acetaminophen (or equivalent), dexamethasone (or equivalent) TBX3 TOP1MT 1
paclitaxel, irinotecan, pembrolizumab, mk-4830, lenvatinib, sacituzumab tirumotecan, antihistamine, h2 receptor antagonist, acetaminophen (or equivalent), dexamethasone (or equivalent) TBX3 RET 1
panitumumab, irinotecan TBX3 TOP1MT 1
pd-1 inhibitors, irinotecan, capecitabine tablets TBX3 TOP1MT 1
pegph20, oxaliplatin, leucovorin, irinotecan, 5-fluorouracil TBX3 TOP1MT 1
pembrolizumab, coformulation favezelimab/pembrolizumab, mk-4830, lenvatinib, irinotecan, paclitaxel TBX3 TOP1MT 1
pembrolizumab, coformulation favezelimab/pembrolizumab, mk-4830, lenvatinib, irinotecan, paclitaxel TBX3 RET 1
pembrolizumab, lenvatinib, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, paclitaxel TBX3 RET 1
pembrolizumab, vorinostat, temozolomide, radiotherapy TBX3 HDAC3 1
pep02, irinotecan, docetaxel TBX3 TOP1MT 1
pm8002, paclitaxel, topotecan TBX3 TOP1MT 1
ponatinib TBX3 RET 1
radiation therapy, temozolomide, sorafenib TBX3 RET 1
regorafenib, lomustine TBX3 RET 1
regorafenib, nivolumab, capeox, folfox regimen TBX3 RET 1
regorafenib, nivolumab, docetaxel, paclitaxel, irinotecan, trifluridine/tipracil TBX3 TOP1MT 1
regorafenib, nivolumab, docetaxel, paclitaxel, irinotecan, trifluridine/tipracil TBX3 RET 1
regorafenib, temozolomide TBX3 RET 1
reolysin®, chemotherapy, gemcitabine, irinotecan, leucovorin, 5-fluorouracil, pembrolizumab TBX3 TOP1MT 1
rmc-6236, gemcitabine, nab-paclitaxel, irinotecan, liposomal irinotecan, 5-fluorouracil, leucovorin, oxaliplatin TBX3 TOP1MT 1
sacituzumab tirumotecan, trifluridine-tipiracil, irinotecan, paclitaxel, docetaxel, rescue medication, supportive care measures TBX3 TOP1MT 1
serplulimab, lenvatinib, paclitaxel/paclitaxel-albumin/paclitaxel liposome TBX3 RET 1
shr-a1904, paclitaxel, docetaxel, irinotecan TBX3 TOP1MT 1
si-b001, irinotecan TBX3 TOP1MT 1
simmitinib plus irinotecan liposome, irinotecan liposome, irinotecan TBX3 TOP1MT 1
sirolimus, vandetanib TBX3 RET 1
sorafenib, erlotinb TBX3 RET 1
sorafenib, rad001 TBX3 RET 1
sorafenib, radiofrequency ablation (rfa) or surgery, everolimus, lanreotide TBX3 RET 1
surufatinib, irinotecan TBX3 TOP1MT 1
tace, lenvatinib, combined with tislelizumab group TBX3 RET 1
tace, tislelizumab, lenvatinib TBX3 RET 1
tamoxifen citrate, bortezomib TBX3 PSMB5 1
Approval data manually curated from National Cancer Institute and Drugs@FDA. Clinical trials from ClinicalTrials.gov. Repositionable candidates from cansar.ai — these are potential drug-cancer reuse candidates, not evidence of efficacy.