Drugs that target a gene either directly (oncogene) or via a synthetic-lethal partner (SLP) of a mutated tumour suppressor (TSG). Cell colour shows the strongest known status of that drug for that cancer subtype: approved clinical trial repositionable (potential reuse, no evidence yet) or blank.
| Drug | TSG | SLP (drug target) | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | # |
|---|---|---|---|---|---|---|---|---|---|---|
| docetaxel, thalidomide | SMARCB1 | BCL2 | 4 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | SMARCB1 | ABL1 | 4 | |||||||
| neo212 oral capsule, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, folfiri protocol, bevacizumab | SMARCB1 | BCL2 | 4 | |||||||
| regorafenib, (stivarga, bay73-4506), nivolumab (opdivo) | SMARCB1 | ABL1 | 4 | |||||||
| 7-hydroxystaurosporine, irinotecan hydrochloride, diagnostic laboratory biomarker analysis | SMARCB1 | PDPK1 | 3 | |||||||
| ab122, ab122, tas-116, ab122, tas-116, ab122, tas-116, ab122, tas-120, ab122, tas-115, ab122, tas-115, ab122, tas-102, ramucirumab, ab122, tas-102, bevacizumab, ab122, ab122, tas-120, fluorouracil, cisplatin, ab122, tas-120, ab154, ab122, tas-120, fluorouracil, carboplatin, cisplatin, ab122, tas-120, ab154, ab122, tas-120, carboplatin, nab-paclitaxel, ab122, tas-120, cisplatin, gemcitabine, ab122, tas-120, nab-paclitaxel, gemcitabine | SMARCB1 | TYMS | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | SMARCB1 | ABL1 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | SMARCB1 | EPHB4 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | SMARCB1 | PIK3CB | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | SMARCB1 | SMO | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | SMARCB1 | MAP2K1 | 3 | |||||||
| adavosertib, afatinib, afatinib dimaleate, binimetinib, biopsy, biospecimen collection, capivasertib, computed tomography, copanlisib, copanlisib hydrochloride, crizotinib, cytology specimen collection procedure, dabrafenib, dabrafenib mesylate, dasatinib, defactinib, defactinib hydrochloride, echocardiography, erdafitinib, fexagratinib, ipatasertib, laboratory biomarker analysis, larotrectinib, larotrectinib sulfate, magnetic resonance imaging, multigated acquisition scan, nivolumab, osimertinib, palbociclib, pertuzumab, pi3k-beta inhibitor gsk2636771, radiologic examination, radionuclide imaging, relatlimab, sapanisertib, sunitinib malate, taselisib, trametinib, trastuzumab, trastuzumab emtansine, ulixertinib, vismodegib | SMARCB1 | FGFR3 | 3 | |||||||
| amg 193, docetaxel, comparator amg 193 test tablet | SMARCB1 | BCL2 | 3 | |||||||
| bms-986340, bms-936558-01, docetaxel | SMARCB1 | BCL2 | 3 | |||||||
| capecitabine, cisplatin | SMARCB1 | TYMS | 3 | |||||||
| dec-205/ny-eso-1 fusion protein cdx-1401, laboratory biomarker analysis, pharmacological study, sirolimus | SMARCB1 | MTOR | 3 | |||||||
| futibatinib, pembrolizumab, cisplatin, 5-fu, oxaliplatin, leucovorin, levoleucovorin, irinotecan | SMARCB1 | FGFR3 | 3 | |||||||
| gemcitabine | SMARCB1 | TYMS | 3 | |||||||
| pembrolizumab, belzutifan, lenvatinib | SMARCB1 | FGFR3 | 3 | |||||||
| srf617, gemcitabine, albumin-bound paclitaxel, pembrolizumab | SMARCB1 | TYMS | 3 | |||||||
| capecitabine | SMARCB1 | TYMS | 6 | |||||||
| everolimus | SMARCB1 | MTOR | 6 | |||||||
| nintedanib | SMARCB1 | FGFR3 | 6 | |||||||
| regorafenib | SMARCB1 | ABL1 | 6 | |||||||
| 5-fu, atezolizumab, bevacizumab, gemcitabine, leucovorin, nab-paclitaxel, oxaliplatin, capecitabine, cisplatin | SMARCB1 | TYMS | 2 | |||||||
| ab598, zimberelimab, fluorouracil, leucovorin, oxaliplatin | SMARCB1 | TYMS | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | SMARCB1 | ABL1 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | SMARCB1 | BCL2 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | SMARCB1 | TYMS | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | SMARCB1 | MAP2K1 | 2 | |||||||
| alectinib, brigatinib, lorlatinib 100 mg, osimertinib, sotorasib, dabrafenib, trametinib, selpercatinib, pembrolizumab, cemiplimab, nivolumab, carboplatin, pemetrexed, paclitaxel | SMARCB1 | FGFR3 | 2 | |||||||
| alendronate, etidronate, ibandronate, risedronate, raloxifene | SMARCB1 | ESR2 | 2 | |||||||
| alvocidib, paclitaxel | SMARCB1 | BCL2 | 2 | |||||||
| alvocidib, paclitaxel | SMARCB1 | CDK9 | 2 | |||||||
| asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan | SMARCB1 | BCL2 | 2 | |||||||
| asp2138, pembrolizumab, oxaliplatin, leucovorin, fluorouracil, ramucirumab, paclitaxel, irinotecan | SMARCB1 | TYMS | 2 | |||||||
| asp3082, cetuximab, leucovorin, oxaplatin, fluorouracil, irinotecan, nanoparticle albumin-bound-paclitaxel, gemcitabine | SMARCB1 | TYMS | 2 | |||||||
| avelumab, lorlatanib, talazoparib, pemetrexed, axitinib, cmp 001, utomilumab, pf04518600 | SMARCB1 | TYMS | 2 | |||||||
| bbi-355, erlotinib, futibatinib | SMARCB1 | FGFR3 | 2 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | SMARCB1 | ABL1 | 2 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | SMARCB1 | EPHB4 | 2 | |||||||
| bevacizumab, dasatinib, fluorouracil, leucovorin, leucovorin calcium, oxaliplatin, quality-of-life assessment | SMARCB1 | TYMS | 2 | |||||||
| bevacizumab, oxaliplatin, leucovorin calcium, fluorouracil, therapeutic conventional surgery, laboratory biomarker analysis | SMARCB1 | TYMS | 2 | |||||||
| binimetinib, biopsy, biospecimen collection, bone scan, computed tomography, magnetic resonance imaging, palbociclib | SMARCB1 | MAP2K1 | 2 | |||||||
| biospecimen collection, computed tomography, devimistat, fluorouracil, gemcitabine hydrochloride, hydroxychloroquine, magnetic resonance imaging | SMARCB1 | TYMS | 2 | |||||||
| biospecimen collection, computed tomography, pemetrexed | SMARCB1 | TYMS | 2 | |||||||
| bryostatin 1, paclitaxel | SMARCB1 | BCL2 | 2 | |||||||
| btla inhibitor (js004), toripalimab, paclitaxel, cisplatin | SMARCB1 | BCL2 | 2 | |||||||
| capecitabine, carboplatin, epirubicin hydrochloride | SMARCB1 | TYMS | 2 | |||||||
| capecitabine, docetaxel | SMARCB1 | BCL2 | 2 | |||||||
| capecitabine, docetaxel | SMARCB1 | TYMS | 2 | |||||||
| capecitabine, irinotecan hydrochloride | SMARCB1 | TYMS | 2 | |||||||
| capecitabine, oxaliplatin | SMARCB1 | TYMS | 2 | |||||||
| capecitabine, oxaliplatin, gene expression analysis, microarray analysis, reverse transcriptase-polymerase chain reaction, adjuvant therapy, biopsy, conventional surgery, neoadjuvant therapy, quality-of-life assessment, radiation therapy | SMARCB1 | TYMS | 2 | |||||||
| capecitabine, temozolomide | SMARCB1 | TYMS | 2 | |||||||
| carboplatin, celecoxib, paclitaxel, adjuvant therapy, conventional surgery, neoadjuvant therapy | SMARCB1 | PDPK1 | 2 | |||||||
| carboplatin, celecoxib, paclitaxel, adjuvant therapy, conventional surgery, neoadjuvant therapy | SMARCB1 | BCL2 | 2 | |||||||
| carboplatin, endoscopic biopsy, external beam radiation therapy, lenvatinib mesylate, paclitaxel, pembrolizumab, resection | SMARCB1 | BCL2 | 2 | |||||||
| carboplatin, esophagectomy, intensity-modulated radiation therapy, paclitaxel, proton beam radiation therapy, quality-of-life assessment, questionnaire administration, folfox regimen, capox regimen, docetaxel, 5fu | SMARCB1 | BCL2 | 2 | |||||||
| carboplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy | SMARCB1 | BCL2 | 2 | |||||||
| carboplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy | SMARCB1 | TYMS | 2 | |||||||
| carboplatin, paclitaxel, panitumumab, radiotherapy | SMARCB1 | BCL2 | 2 | |||||||
| carboplatin, paclitaxel, radiation therapy, telomerase-specific type 5 adenovirus obp-301 | SMARCB1 | BCL2 | 2 | |||||||
| carboplatin, paclitaxel, three-dimensional conformal radiation therapy | SMARCB1 | BCL2 | 2 | |||||||
| cetuximab, cisplatin, docetaxel, adjuvant therapy, neoadjuvant therapy | SMARCB1 | BCL2 | 2 | |||||||
| cetuximab, cisplatin, fluorouracil, conventional surgery | SMARCB1 | TYMS | 2 | |||||||
| cft1946, trametinib, cetuximab | SMARCB1 | MAP2K1 | 2 | |||||||
| chemotherapy, cisplatin, fluorouracil, low-let electron therapy, low-let photon therapy | SMARCB1 | TYMS | 2 | |||||||
| chemotherapy, cisplatin, paclitaxel, low-let electron therapy, low-let photon therapy | SMARCB1 | BCL2 | 2 | |||||||
| cisplatin, docetaxel, irinotecan hydrochloride, radiation therapy | SMARCB1 | BCL2 | 2 | |||||||
| cisplatin, fluorouracil, conventional surgery, neoadjuvant therapy, radiation therapy | SMARCB1 | TYMS | 2 | |||||||
| cisplatin, fluorouracil, iressa, conventional surgery, radiation therapy | SMARCB1 | TYMS | 2 | |||||||
| cisplatin, fluorouracil, paclitaxel, conventional surgery, neoadjuvant therapy, radiation therapy | SMARCB1 | BCL2 | 2 | |||||||
| cisplatin, fluorouracil, paclitaxel, conventional surgery, neoadjuvant therapy, radiation therapy | SMARCB1 | TYMS | 2 | |||||||
| cisplatin, fluorouracil, paclitaxel, surgical procedure, radiation therapy | SMARCB1 | BCL2 | 2 | |||||||
| cisplatin, fluorouracil, paclitaxel, surgical procedure, radiation therapy | SMARCB1 | TYMS | 2 | |||||||
| cisplatin, fluorouracil, surgical procedure, radiation therapy | SMARCB1 | TYMS | 2 | |||||||
| cisplatin, paclitaxel, surgical procedure, radiation therapy | SMARCB1 | BCL2 | 2 | |||||||
| cisplatin, pemetrexed, gemcitabine, carboplatin, certolizumab, nivolumab | SMARCB1 | TYMS | 2 | |||||||
| cixutumumab, laboratory biomarker analysis, paclitaxel, pharmacological study | SMARCB1 | BCL2 | 2 | |||||||
| cobimetinib, mehd7945a | SMARCB1 | MAP2K1 | 2 | |||||||
| cpt- 11, cisplatin, celecoxib, radiation, surgery | SMARCB1 | PDPK1 | 2 | |||||||
| dkn-01 150 mg, paclitaxel, pembrolizumab, dkn-01 300 mg | SMARCB1 | BCL2 | 2 | |||||||
| docetaxel, 5-fu, radiotherapy, esophagectomy, dexamethasone | SMARCB1 | BCL2 | 2 | |||||||
| durvalumab, tremelimumab, oxaliplatin, capecitabine, radiotherapy, paclitaxel, carboplatin, 5-fluorouracil (5-fu), leucovorin, docetaxel | SMARCB1 | BCL2 | 2 | |||||||
| durvalumab, tremelimumab, oxaliplatin, capecitabine, radiotherapy, paclitaxel, carboplatin, 5-fluorouracil (5-fu), leucovorin, docetaxel | SMARCB1 | TYMS | 2 | |||||||
| entrectinib, entrectinib, alectinib, atezolizumab, ipatasertib, trastuzumab emtansine, idasanutlin, inavolisib, belvarafenib, pralsetinib, gdc-6036, camonsertib | SMARCB1 | JAK2 | 2 | |||||||
| erlotinib hydrochloride, oxaliplatin, fluorouracil, radiation therapy, conventional surgery, immunohistochemistry staining method, positron emission tomography, computed tomography, laboratory biomarker analysis, gene expression analysis, fludeoxyglucose f 18 | SMARCB1 | TYMS | 2 | |||||||
| filgrastim, cisplatin, fluorouracil, paclitaxel, radiation therapy | SMARCB1 | BCL2 | 2 | |||||||
| filgrastim, cisplatin, fluorouracil, paclitaxel, radiation therapy | SMARCB1 | TYMS | 2 | |||||||
| filgrastim, pegfilgrastim, cisplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy | SMARCB1 | BCL2 | 2 | |||||||
| filgrastim, pegfilgrastim, cisplatin, fluorouracil, paclitaxel, conventional surgery, radiation therapy | SMARCB1 | TYMS | 2 | |||||||
| fluorouracil, gemcitabine hydrochloride, leucovorin calcium | SMARCB1 | TYMS | 2 | |||||||
| fluorouracil, irinotecan hydrochloride, leucovorin calcium, pharmacogenomic studies, pharmacological study | SMARCB1 | TYMS | 2 | |||||||
| fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study | SMARCB1 | TYMS | 2 | |||||||
| fluorouracil, irinotecan hydrochloride, leucovorin calcium, vorinostat, pharmacological study | SMARCB1 | HDAC2 | 2 | |||||||
| fluorouracil, oxaliplatin, conventional surgery, radiation therapy | SMARCB1 | TYMS | 2 | |||||||
| gi-101, pembrolizumab (keytruda®), lenvatinib, local radiotherapy, gi-101a | SMARCB1 | FGFR3 | 2 | |||||||
| inbrx-109, carboplatin, cisplatin, pemetrexed, 5-fluorouracil, irinotecan, temozolomide | SMARCB1 | TYMS | 2 | |||||||
| ioa-244, avelumab injection, pemetrexed, cisplatin, ruxolitinib | SMARCB1 | JAK2 | 2 | |||||||
| ioa-244, avelumab injection, pemetrexed, cisplatin, ruxolitinib | SMARCB1 | TYMS | 2 | |||||||
| irinotecan, capecitabine | SMARCB1 | TYMS | 2 | |||||||
| irinotecan, docetaxel | SMARCB1 | BCL2 | 2 | |||||||
| jab-3312, binimetinib, pembrolizumab, sotorasib, osimertinib | SMARCB1 | MAP2K1 | 2 | |||||||
| laboratory biomarker analysis, oxaliplatin, pralatrexate | SMARCB1 | TYMS | 2 | |||||||
| lenvatinib, pembrolizumab | SMARCB1 | FGFR3 | 2 | |||||||
| lenvatinib, pembrolizumab, hyperpolarized 13c-pyruvate | SMARCB1 | FGFR3 | 2 | |||||||
| ly4066434., cetuximab, nab paclitaxel, gemcitabine, oxaliplatin, leucovorin, irinotecan, 5fluorouracil, carboplatin, cisplatin, pemetrexed, pembrolizumab | SMARCB1 | TYMS | 2 | |||||||
| m6620, cisplatin, capecitabine, radiotherapy | SMARCB1 | TYMS | 2 | |||||||
| melphalan, bcnu, vitamin b12b, vitamin c, ethanol, autologous hematopoietic stem cells | SMARCB1 | CACNG1 | 2 | |||||||
| melphalan, bcnu, vitamin b12b, vitamin c, ethanol, autologous hematopoietic stem cells | SMARCB1 | CHRNA9 | 2 | |||||||
| mirdametinib, bgb-3245 | SMARCB1 | MAP2K1 | 2 | |||||||
| mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed | SMARCB1 | BCL2 | 2 | |||||||
| mk-0482, pembrolizumab, paclitaxel, nab-paclitaxel, gemcitabine, carboplatin, pemetrexed | SMARCB1 | TYMS | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | SMARCB1 | BCL2 | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | SMARCB1 | TYMS | 2 | |||||||
| mk-4830, pembrolizumab, carboplatin, pemetrexed, lenvatinib, paclitaxel, cisplatin, mk-4830a | SMARCB1 | FGFR3 | 2 | |||||||
| nintedanib, pembrolizumab | SMARCB1 | FGFR3 | 2 | |||||||
| ociperlimab, tislelizumab, pemetrexed, paclitaxel, nab paclitaxel, carboplatin, cisplatin, etoposide, 5fluorouracil, oxaliplatin, capecitabine | SMARCB1 | BCL2 | 2 | |||||||
| ociperlimab, tislelizumab, pemetrexed, paclitaxel, nab paclitaxel, carboplatin, cisplatin, etoposide, 5fluorouracil, oxaliplatin, capecitabine | SMARCB1 | TYMS | 2 | |||||||
| olaparib | SMARCB1 | PARP3 | 2 | |||||||
| oleclumab, durvalumab, gemcitabine, nab-paclitaxel, oxaliplatin, folinic acid, 5-fu | SMARCB1 | TYMS | 2 | |||||||
| onc-392, pembrolizumab, docetaxel | SMARCB1 | BCL2 | 2 | |||||||
| oxaliplatin, irinotecan hydrochloride, leucovorin calcium, fluorouracil, laboratory biomarker analysis | SMARCB1 | TYMS | 2 | |||||||
| pembrolizumab, guadecitabine, mocetinostat | SMARCB1 | HDAC2 | 2 | |||||||
| pembrolizumab, lenvatinib | SMARCB1 | FGFR3 | 2 | |||||||
| pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu | SMARCB1 | TYMS | 2 | |||||||
| pembrolizumab, lenvatinib, oxaliplatin, capecitabine, leucovorin (or levoleucovorin), 5-fu | SMARCB1 | FGFR3 | 2 | |||||||
| pembrolizumab, paclitaxel, docetaxel, irinotecan | SMARCB1 | BCL2 | 2 | |||||||
| pembrolizumab, sonidegib | SMARCB1 | SMO | 2 | |||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | SMARCB1 | BCL2 | 2 | |||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | SMARCB1 | TYMS | 2 | |||||||
| pembrolizumab/vibostolimab co-formulation, pembrolizumab, lenvatinib, 5-fluorouracil, cisplatin, paclitaxel, gemcitabine, carboplatin, docetaxel, bevacizumab, capecitabine, oxaliplatin | SMARCB1 | FGFR3 | 2 | |||||||
| pemetrexed, bevacizumab | SMARCB1 | TYMS | 2 | |||||||
| pharmacological study, romidepsin | SMARCB1 | HDAC2 | 2 | |||||||
| pralatrexate, docetaxel, fludeoxyglucose f 18, positron emission tomography | SMARCB1 | BCL2 | 2 | |||||||
| pralatrexate, docetaxel, fludeoxyglucose f 18, positron emission tomography | SMARCB1 | TYMS | 2 | |||||||
| quality-of-life assessment, questionnaire administration, selpercatinib, therapeutic conventional surgery | SMARCB1 | FGFR3 | 2 | |||||||
| ramucirumab, paclitaxel | SMARCB1 | BCL2 | 2 | |||||||
| regorafenib, laboratory biomarker analysis | SMARCB1 | ABL1 | 2 | |||||||
| sar444881, pembrolizumab, cetuximab, carboplatin, pemetrexed | SMARCB1 | TYMS | 2 | |||||||
| selumetinib, medi4736, tremelimumab | SMARCB1 | MAP2K1 | 2 | |||||||
| tislelizumab, pemetrexed | SMARCB1 | TYMS | 2 | |||||||
| whole brain low dose radiotherapy, pemetrexed, sintilimab, chemotherapy | SMARCB1 | TYMS | 2 | |||||||
| binimetinib | SMARCB1 | MAP2K1 | 6 | |||||||
| bosutinib | SMARCB1 | ABL1 | 6 | |||||||
| entrectinib | SMARCB1 | JAK2 | 6 | |||||||
| erdafitinib | SMARCB1 | FGFR3 | 6 | |||||||
| pazopanib | SMARCB1 | FGFR3 | 6 | |||||||
| pemigatinib | SMARCB1 | FGFR3 | 6 | |||||||
| ponatinib | SMARCB1 | ABL1 | 6 | |||||||
| romidepsin | SMARCB1 | HDAC2 | 6 | |||||||
| tadalafil | SMARCB1 | PDE5A | 6 | |||||||
| 18f-fluoromisonidazole, cediranib maleate, laboratory biomarker analysis, olaparib, positron emission tomography | SMARCB1 | PARP3 | 1 | |||||||
| 3-dimensional conformal radiation therapy, biospecimen collection, capecitabine, chemotherapy, computed tomography, erlotinib hydrochloride, fluorouracil, gemcitabine hydrochloride, intensity-modulated radiation therapy, magnetic resonance imaging, quality-of-life assessment, x-ray imaging | SMARCB1 | TYMS | 1 | |||||||
| 3-dimensional conformal radiation therapy, cognitive assessment, laboratory biomarker analysis, temozolomide, vorinostat | SMARCB1 | HDAC2 | 1 | |||||||
| 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, laboratory biomarker analysis, vorinostat | SMARCB1 | HDAC2 | 1 | |||||||
| 4-dimensional computed tomography, fluorouracil, gemcitabine hydrochloride, laboratory biomarker analysis, leucovorin calcium, nelfinavir mesylate, oregovomab, stereotactic body radiation therapy, therapeutic conventional surgery | SMARCB1 | TYMS | 1 | |||||||
| 5-fluorouracil (5-fu), leucovorin, oxaliplatin, atezolizumab, cobimetinib, ramucirumab, paclitaxel, pegylated recombinant human hyaluronidase (pegph20), bl-8040, linagliptin, atezolizumab, cobimetinib, cisplatin, tiragolumab, 5-fluorouracil (5-fu) | SMARCB1 | BCL2 | 1 | |||||||
| 5-fluorouracil (5-fu), leucovorin, oxaliplatin, atezolizumab, cobimetinib, ramucirumab, paclitaxel, pegylated recombinant human hyaluronidase (pegph20), bl-8040, linagliptin, atezolizumab, cobimetinib, cisplatin, tiragolumab, 5-fluorouracil (5-fu) | SMARCB1 | MAP2K1 | 1 | |||||||
| 5-fluorouracil, docetaxel, oxaliplatin | SMARCB1 | BCL2 | 1 | |||||||
| 5-fluorouracil, leucovorin, oxaliplatin, docetaxel, carboplatin, paclitaxel, neoadjuvant radiation | SMARCB1 | BCL2 | 1 | |||||||
| 5-fluoruracil, cisplatinum, docetaxel | SMARCB1 | BCL2 | 1 | |||||||
| 5-fu, leucovorin, docetaxel, oxaliplatin (flot), trastuzumab, post-operative treatment trastuzumab mono therapy | SMARCB1 | BCL2 | 1 | |||||||
| 6,8-bis(benzylthio)octanoic acid, oxaliplatin, leucovorin calcium, irinotecan hydrochloride, fluorouracil, laboratory biomarker analysis | SMARCB1 | TYMS | 1 | |||||||
| 7-hydroxystaurosporine, fluorouracil | SMARCB1 | PDPK1 | 1 | |||||||
| 7-hydroxystaurosporine, fluorouracil | SMARCB1 | TYMS | 1 | |||||||
| 7-hydroxystaurosporine, gemcitabine hydrochloride, pharmacological study, laboratory biomarker analysis | SMARCB1 | PDPK1 | 1 | |||||||
| 9-ing-41, retifanlimab, gemcitabine, abraxane | SMARCB1 | TYMS | 1 | |||||||
| abbv-400, budigalimab, fluorouracil, leucovorin, oxaliplatin | SMARCB1 | TYMS | 1 | |||||||
| abemaciclib, ly3023414, gemcitabine, capecitabine | SMARCB1 | TYMS | 1 | |||||||
| abraxane (nab-paclitaxel), gemcitabine | SMARCB1 | TYMS | 1 | |||||||
| adct-601, gemcitabine | SMARCB1 | TYMS | 1 | |||||||
| adebrelimab, apatinib, tegafur | SMARCB1 | TYMS | 1 | |||||||
| adjuvant therapy, temozolomide, valproic acid, radiation therapy | SMARCB1 | HDAC2 | 1 | |||||||
| aee788, everolimus | SMARCB1 | MTOR | 1 | |||||||
| afatinib dimaleate, capecitabine, laboratory biomarker analysis | SMARCB1 | TYMS | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | SMARCB1 | PARP3 | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | SMARCB1 | ABL1 | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | SMARCB1 | EPHB4 | 1 | |||||||
| afatinib, dasatinib, palbociclib, everolimus, olaparib | SMARCB1 | MTOR | 1 | |||||||
| afatinib, docetaxel, radiation therapy | SMARCB1 | BCL2 | 1 | |||||||
| afuresertib, nab paclitaxel, docetaxel, sintilimab | SMARCB1 | BCL2 | 1 | |||||||
| ag-013736, gemcitabine, gemcitabine, placebo | SMARCB1 | TYMS | 1 | |||||||
| agen1423, botensilimab, gemcitabine, nab-paclitaxel | SMARCB1 | TYMS | 1 | |||||||
| agent-797, botensilimab, balstilimab, ramucirumab, paclitaxel | SMARCB1 | BCL2 | 1 | |||||||
| ags-1c4d4, gemcitabine | SMARCB1 | TYMS | 1 | |||||||
| ak104, ak104, gemcitabine, nab-paclitaxel | SMARCB1 | TYMS | 1 | |||||||
| ak104, oxaliplatin, capecitabine | SMARCB1 | TYMS | 1 | |||||||
| ak109, paclitaxel, paclitaxel, ak104 | SMARCB1 | BCL2 | 1 | |||||||
| ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, cadonilimab, nab-paclitaxel, gemcitabine, ak112, nab-paclitaxel, gemcitabine, nab-paclitaxel, gemcitabine | SMARCB1 | TYMS | 1 | |||||||
| akt inhibitor mk2206, fluorouracil, oxaliplatin, selumetinib | SMARCB1 | TYMS | 1 | |||||||
| akt inhibitor mk2206, fluorouracil, oxaliplatin, selumetinib | SMARCB1 | MAP2K1 | 1 | |||||||
| albumin-bound paclitaxel (abi-007), gemcitabine | SMARCB1 | TYMS | 1 | |||||||
| aldesleukin, antibody therapy, fluorouracil, gemcitabine hydrochloride, irinotecan hydrochloride, laboratory biomarker analysis, leucovorin calcium, oxaliplatin, paclitaxel albumin-stabilized nanoparticle formulation, sargramostim | SMARCB1 | IL2RB | 1 | |||||||
| aldesleukin, antibody therapy, fluorouracil, gemcitabine hydrochloride, irinotecan hydrochloride, laboratory biomarker analysis, leucovorin calcium, oxaliplatin, paclitaxel albumin-stabilized nanoparticle formulation, sargramostim | SMARCB1 | TYMS | 1 | |||||||
| aldesleukin, autologous tumor cell vaccine, filgrastim, sargramostim, therapeutic autologous lymphocytes, carmustine, cisplatin, cyclophosphamide, paclitaxel, autologous bone marrow transplantation, conventional surgery, peripheral blood stem cell transplantation | SMARCB1 | IL2RB | 1 | |||||||
| aldesleukin, autologous tumor cell vaccine, filgrastim, sargramostim, therapeutic autologous lymphocytes, carmustine, cisplatin, cyclophosphamide, paclitaxel, autologous bone marrow transplantation, conventional surgery, peripheral blood stem cell transplantation | SMARCB1 | BCL2 | 1 | |||||||
| aldesleukin, autologous tumor cell vaccine, muromonab-cd3, sargramostim, therapeutic autologous lymphocytes, surgical procedure, radiation therapy | SMARCB1 | IL2RB | 1 | |||||||
| aldesleukin, biopsy, biospecimen collection, computed tomography, cyclophosphamide, excisional biopsy, fludarabine, magnetic resonance imaging, standard treatment, therapeutic tumor infiltrating lymphocytes | SMARCB1 | IL2RB | 1 |