Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins.
The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (PubMed:7947975). Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection.
In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (Probable). Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products (By similarity)
Homodimer
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Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to PTGS1, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 7
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT00115752 | Pain | Genetic Basis For Variation In NSAID Analgesia In A Clinical Model Of Acute Pain | PHASE2 | COMPLETED |
| NCT00753935 | Coronary Artery Disease | Aspirin Resistance in Coronary Artery Disease | EARLY_PHASE1 | COMPLETED |
| NCT02902913 | Cardiovascular Diseases | Impact of Extra Virgin Olive Oil Oleocanthal Content on Platelet Reactivity | NA | COMPLETED |
| NCT00001742 | Healthy, Hypercholesterolemia, Hypertension | The Role of Cyclooxygenase Activity in the Endothelial Function of Hypertensive and Hypercholesterolemic Patients | N/A | COMPLETED |
| NCT00778193 | Gastroduodenal Ulcer | Effect of Naproxen, Aspirin, Celecoxib, or Clopidogrel on the Healing of Stomach and Intestinal Ulcers | PHASE4 | COMPLETED |
| NCT06920628 | Long COVID, Post Acute Sequelae of COVID-19 | PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | PHASE1 | RECRUITING |
| NCT00261586 | Analgesics | A Safety Trial to Compare Different Analgesics in Combination With Low Dose Aspirin to Study Their Bleeding Properties and Their Effects on the Stomach | PHASE4 | COMPLETED |
| NCT01269515 | HIV | Immunomodulating Therapy and Improved Vaccination Responses by Cox-2 Inhibitor in HIV-infected Patients | PHASE2 | COMPLETED |
| NCT00710177 | Persistent Pulmonary Hypertension of the Newborn | PTGS1 Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn | N/A | RECRUITING |
| NCT05062083 | Multiple Sclerosis | PET Imaging of Cyclooxygenase in Multiple Sclerosis | PHASE2 | TERMINATED |