Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:1645757, PubMed:2153297, PubMed:2557822). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369)
(Microbial infection) Interacts with HIV-1 Tat
There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases)
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
Click a pathway to open the interactive Reactome viewer.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to MMP11, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 109
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT02014857 | Smoking, Healthy Volenteers | Evaluation of GCF MMP-1, -8 and Growth Factor Levels in Smokers With Periodontal Health | N/A | COMPLETED |
| NCT00385931 | Hypertension, Hypercholesterolemia, Dyslipidemia | Efficacy and Safety of Valsartan and the Combination of Valsartan and Simvastatin | PHASE3 | COMPLETED |
| NCT05049408 | Oral Squamous Cell Carcinoma | Verification of Saliva MMP-1 as a Diagnostic Marker of Oral Cavity Cancer | N/A | COMPLETED |
| NCT01176032 | Hypertension, Left Ventricle Hypertrophy | ALiskiren or Losartan Effects on bioMARKers of Myocardial Remodeling | PHASE4 | COMPLETED |
| NCT00935051 | Diabetic Foot Ulcer | Matrix Metalloproteinase-1/Tissue Inhibitor of Metalloproteinase-1 (MMP-1/TIMP-1) Ratio and Diabetic Foot Ulcers | EARLY_PHASE1 | COMPLETED |
| NCT03722628 | Hepatocellular Carcinoma | The Assesment of MMP-1 Genotypes Polymorphism as a Risk Factor for HCC in Chronic HCV Patients With LC | N/A | UNKNOWN |
| NCT05131269 | Frozen Shoulder | Prolotherapy Intervention in Patient With Frozen Shoulder | PHASE4 | COMPLETED |
| NCT00312403 | Glaucoma | Polymorphisms in the Human Matrix Metalloproteinase Genes MMP1, MMP3, and MMP9: Genetic Risk Factors of Primary Open Angle Glaucoma? | NA | COMPLETED |