Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway
Homodimer
The N-terminal ATP-grasp domain carries the phosphoribosylamine--glycine ligase activity
The central AIRS domain carries the phosphoribosylformylglycinamidine cyclo-ligase activity
The C-terminal GART domain carries the phosphoribosylglycinamide formyltransferase activity
Click a pathway to open the interactive Reactome viewer.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to GART, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 1
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT00000874 | HIV Infections | A Pilot Study of the Short-Term Effects of Antiretroviral Management Based on Plasma Genotypic Antiretroviral Resistance Testing (GART) Compared With Antiretroviral Management Without Plasma GART | N/A | COMPLETED |