Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation
Heterodimer of FNTA and FNTB (farnesyltransferase) (PubMed:11687658, PubMed:12036349, PubMed:12825937, PubMed:15170324, PubMed:15451670, PubMed:16893176, PubMed:19246009, PubMed:8419339). Heterodimer of FNTA and PGGT1B (geranylgeranyltransferase) (By similarity)
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Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to FNTA, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
No clinical trials information available.