Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806).
Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013)
Liver
A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.
Click a pathway to open the interactive Reactome viewer.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to APOC3, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 18
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT05179954 | Type 1 Diabetes | Lipoprotein Kinetics in T1D | NA | RECRUITING |
| NCT05902598 | Familial Chylomicronemia Syndrome | A Phase 3 Study of ARO-APOC3 / VSA001 / SAR449124 (Plozasiran) in Chinese Adults With Familial Chylomicronemia Syndrome | PHASE3 | COMPLETED |
| NCT05079919 | Severe Hypertriglyceridemia | A Study of Olezarsen (ISIS 678354) Administered to Participants With Severe Hypertriglyceridemia | PHASE3 | COMPLETED |
| NCT02900027 | Elevated Triglycerides (TG) | Safety, Tolerability, PK, and Pharmacodynamics(PD) of IONIS APOCIII-LRx in Healthy Volunteers With Elevated Triglycerides | PHASE1 | COMPLETED |
| NCT07371767 | Hyperchylomicronemia | CS-121 APOC3 Base Editing in Children and Adolescents With Hyperchylomicronemia | EARLY_PHASE1 | RECRUITING |
| NCT06784349 | Dyslipidemia | ALN-APOC3 in Adult Participants With Dyslipidemia | PHASE1 | COMPLETED |
| NCT04720534 | Severe Hypertriglyceridemia | Study to Evaluate ARO-APOC3 in Adults With Severe Hypertriglyceridemia | PHASE2 | COMPLETED |
| NCT02083510 | Hypertriglyceridemia, Gout, Pericarditis | Apolipoprotein CIII Reduction Via Colchicine | EARLY_PHASE1 | COMPLETED |
| NCT07325916 | Morbid Obesity Requiring Bariatric Surgery | Relationship Between Serum Apolipoprotein Levels and Weight Loss in Patients Undergoing Sleeve Gastrectomy for Morbid Obesity | N/A | ACTIVE_NOT_RECRUITING |
| NCT05413135 | Dyslipidemias | Study of ARO-APOC3 in Adults With Dyslipidemia | PHASE2 | COMPLETED |