Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C (By similarity). ADRA1B binds the catecholamine ligands norepinephrine and epinephrine (PubMed:7815325, PubMed:8183249).
Can also couple to G(14) and G(16) proteins (By similarity). Nuclear ADRA1B forms heterooligomers with ADRA1A to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes (PubMed:18802028, PubMed:22120526). At the plasma membrane, ADRA1B interacts with CAVIN4/MURC to regulates ERK activation in cardiomyocytes, contributing to the regulation of cardiac hypertrophy (PubMed:24567387)
Homo- and heterooligomer. Heterooligomerizes with ADRA1A homooligomers in cardiac myocytes (PubMed:22120526). Interacts with CAVIN4 (PubMed:24567387)
Click a pathway to open the interactive Reactome viewer.
Genes with an experimentally identified or computationally predicted synthetic-lethal relationship to ADRA1B, aggregated across our SSL data sources. Click any partner node to view that gene’s page.
Nodes and edges are coloured by the SSL data source. Partners appearing in more than one source are shown in grey.
Total Trials Found: 6
| NCT ID | Condition | Brief Title | Phase | Status |
|---|---|---|---|---|
| NCT07517094 | Intraoperative Floppy Iris Syndrome, Cataract, Age-related Cataract, Adrenergic Receptor Antagonist Adverse Reaction | Pupillary Dilator Muscle Thickness as a Potential Predictor of Intraoperative Floppy Iris Syndrome | N/A | COMPLETED |
| NCT06266962 | Intraoperative Floppy Iris Syndrome, Cataract, Age-related Cataract, Adrenergic Receptor Antagonist Adverse Reaction | Comparing the Efficiency of Two Approaches in Patients at Risk of Developing Intraoperative Floppy Iris Syndrome | PHASE4 | COMPLETED |
| NCT05109364 | Symptomatic Parkinson Disease, REM Sleep Behavior Disorder, Pre-motor Parkinson's Disease | Terazosin and Parkinson's Disease Extension Study | PHASE2 | ACTIVE_NOT_RECRUITING |
| NCT04365257 | COVID-19 | Prazosin to Prevent COVID-19 (PREVENT-COVID Trial) | PHASE2 | TERMINATED |
| NCT00730418 | Benign Prostatic Hyperplasia | Effects of Chronic Use of Doxazosin in Men With Benign Prostatic Hyperplasia | NA | COMPLETED |
| NCT04491526 | Urinary Retention, Inguinal Hernia | Study to Prevent Postoperative Urinary Retention | PHASE4 | TERMINATED |